According to Examine.com
"The recommended oral dose of muira puama appears to be 1000-1500mg of a 4:1 concentrated extract (equivalent to 4,000-6,000mg of the basic extract). It is unsure if this is the optimal dose or whether it needs to be taken with a meal.
100-300mg/kg appears to be the active range for anti-stress and anxiolytic effects in rats, which converts to an estimated human equivalent of:
- 1,100-3,300mg for a 150lb person
- 1,500-4,400mg for a 200lb person
- 1,800-5,500mg for a 250lb person
These are currently the recommended intakes as the higher end of the recommendation is similar to what is recommended to humans that appears to be effective."
3.1. Erectile Properties
One study conducted in men using 1000-1500 mg of a 4:1 extract of Muira Puama noted that 51% of respondents reported an improvement in erectile function after 2 weeks of usage.
Muira puama - Scientific Review on Usage, Dosage, Side Effects ...
https://examine.com/supplements/muira-puama/Muira puama (Marapuama, Potency Wood) is a traditionally used aphrodisiac and nerve tonic in the Brazil region.
- Shamloul R Natural aphrodisiacs. J Sex Med. (2010)
- Tang W, et al. Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides. J Nat Prod. (2008)
- Piato AL, et al. Antidepressant profile of Ptychopetalum olacoides Bentham (Marapuama) in mice. Phytother Res. (2009)
- Is there a psychopharmacological meaning for traditional tonics?.
- Tang W, et al. Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides. Nat Prod Commun. (2011)
- Tang W, et al. Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides. Bioorg Med Chem Lett. (2009)
- Piato AL, et al. Anti-stress effects of the "tonic"Ptychopetalum olacoides (Marapuama) in mice. Phytomedicine. (2010)
- Waynberg J, Brewer S Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women. Adv Ther. (2000)
- Yohimbine vs. Muira puama in the treatment of erectile dysfunction.
- Figueiró M, et al. The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model. Phytomedicine. (2011)
- Figueiró M, et al. Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama).Phytomedicine. (2010)
- Siqueira IR, et al. Ptychopetalum olacoides, a traditional Amazonian "nerve tonic", possesses anticholinesterase activity. Pharmacol Biochem Behav. (2003)
- Siqueira IR, et al. Antioxidant activities of Ptychopetalum olacoides ("muirapuama") in mice brain. Phytomedicine. (2007)
- da Silva AL, et al. MK801- and scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a "brain tonic". Psychopharmacology (Berl). (2009)
- da Silva AL, et al. Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama). Physiol Behav. (2008)
- Psychopharmacological Properties of Ptychopetalum Olacoides bentham (Olacaceae).
- da Silva AL, et al. Promnesic effects of Ptychopetalum olacoides in aversive and non-aversive learning paradigms. J Ethnopharmacol. (2007)
- da Silva AL, et al. Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice. J Ethnopharmacol. (2004)
- Duman CH Models of depression. Vitam Horm. (2010)
- Piato AL, et al. Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties. J Ethnopharmacol. (2008)
- da Silva AL, et al. Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama). Phytother Res. (2002)
- Pontieri V, et al. The herbal drug Catuama reverts and prevents ventricular fibrillation in the isolated rabbit heart. J Electrocardiol. (2007)
- Herbal medicine Catuama induces endothelium-dependent and -independent vasorelaxant action on isolated vessels from rats, guinea-pigs and rabbits.
- Antunes E, et al. The relaxation of isolated rabbit corpus cavernosum by the herbal medicine Catuama and its constituents. Phytother Res. (2001)
- Campos MM, et al. Pharmacological and neurochemical evidence for antidepressant-like effects of the herbal product Catuama. Pharmacol Biochem Behav. (2004)