Wednesday, April 11, 2018

St Johns Wort Excerpt from Ergo-Log: Overweight and depressed? Hypericum perforatum kills two birds with one stone

Excerpt from Ergo-Log

Overweight and depressed? Hypericum perforatum kills two birds with one stone

You are probably familiar with Hypericum perforatum as a herb that has a mild antidepressant effect, but according to researchers at Banaras Hindu University in India it has other potential uses too. When the Indians gave lab animals an extract of the herb they discovered that it also had a slimming effect.

The human equivalent of these doses would be about 1200-2400 mg extract per day.

"Taken together, Hypericum perforatum could be the antidepressant therapy of choice for patients suffering from comorbid diabetes and obesity", the researchers concluded.

Hypericum perforatum has many side effects. Make sure you read up about it carefully before experimenting with the stuff.

St John's Wort makes fat cells resistant to insulin 25.08.2009

Hypericum perforatum - Scientific Review on Usage ... -

Hypericum Perforatum (St. John's Wort) is an anti-depressant herb that is commonly used for its neurological effects. While it appears effective, it is well known to adversely interact with a variety of pharmaceuticals.

Saturday, April 7, 2018

Super K with Advanced K2 Complex

LE Certified Non-GMO
Better Nutrition 2017 Best of Supplements Award Winner

Super K with Advanced K2 Complex provides the three forms of vitamin K that can be utilized by the body: vitamin K1 and dual forms of K2, MK-4 and MK-7. This comprehensive vitamin K formula promotes both bone and arterial health. So boost your vitamin K levels with the one-two punch of both K1 and K2, add Super K with Advanced K2 Complex to your nutrient regimen today!
Benefits at a Glance:
  • Maintains bone density by facilitating calcium transport into bone
  • Promotes a healthy heart and vascular system
  • Includes the most bioavailable forms of vitamin K1 and K2
  • Bioavailable over a sustained 24-hour period
The method by which vitamin K supports bones and arteries is related to its relationship with calcium. Research has shown that low vitamin K status interferes with the function of a protein called matrix Gla-protein (MGP). This protein is vitamin K dependent and must be carboxylated to function properly.1
Without adequate vitamin K, MGP remains uncarboxylated. Studies have found that uncarboxylated MGP accumulates at the site of arterial calcification.2,3 Without normal levels of carboxylated MGP, calcium in the blood can bind to the arterial wall resulting in calcification.4,5
Health benefits of vitamin K
The Rotterdam Heart Study, a large-scale, well-controlled clinical trial that tracked 4,800 subjects for seven years, revealed that people who consume the most dietary K2 have healthier hearts when compared to people who consume the least.6Additional studies have shown that higher vitamin K levels also correspond to less calcium deposits in the aorta, and can even cause a 37% regression of preformed arterial calcification.7,8
Different forms of Vitamin K
Unfortunately, obtaining enough vitamin K through the diet can be difficult. The most common form of vitamin K, known as K1, is present in leafy green vegetables. Not only do many people avoid these vegetables, the K1 is tightly bound to plant fibers and not easily absorbable.9-11
In contrast, vitamin K2, which is found in meat, egg yolks, and dairy, is up to 10 times more bioavailable than K1 and remains active in the body for far longer.12 If you're avoiding these foods for health reasons, it’s essential to take a K2 supplement.
Super K with Advanced K2 Complex makes it easier to get enough vitamin K by including two forms of vitamin K2, MK-4 and MK-7. The MK-4 form is the most rapidly absorbed type of vitamin K. However, it only lasts in the bloodstream for a few hours.13 In contrast, the MK-7 form is available to the body for a full 24-hour period14 at much higher levels.12
A complete Vitamin K supplement
Combining two forms of vitamin K2 provides both rapid and sustained absorption of this critical nutrient, so your healthy blood levels are maintained throughout the day. Just one daily softgel of Super K with Advanced K2 Complex provides 100 mcg of vitamin K2 (MK-7); 1,000 mcg of vitamin K2 (MK-4); and 1,500 mcg of vitamin K1. This K2 complex, plus a strong dose of K1, makes this comprehensive formula an excellent way to get your vitamin K!
  1. Osteoporos Int. 2013 Sep;24(9):2499-507.
  2. Atherosclerosis. 2012 Dec;225(2):397-402.
  3. Adv Nutr. 2012 Mar 1;3(2):166-73.
  4. Thromb Haemost. 2008 Oct;100(4):593-603.
  5. Clin J Am Soc Nephrol. 2008 Sep;3(5):1504-10.
  6. J Nutr. 2004 Nov;134(11):3100-5.
  7. Blood. 2007 Apr 1;109(7):2823-31.
  8. J Vasc Res. 2003 Nov-Dec;40(6):531-7.
  9. J Nutr. 1999 Jun;129(6):1201-3.
  10. Br J Nutr. 2010 Sep;104(6):858-62.
  11. J Nutr. 2002 Sep;132(9):2609-12.
  12. Blood. 2007 Apr 15;109(8):3279-83.
  13. Br J Nutr. 1996 Aug;76(2):223-9.
  14. Nutr J. 2012 Nov 12;11:93.


Supplement Facts
Serving Size 1 softgel
Amount Per Serving
Vitamin C (as Ascorbyl palmitate)
10 mg
Vitamin K activity
2600 mcg
Vitamin K1 (as phytonadione)
1500 mcg
Vitamin K2 (as menaquinone-4)
1000 mcg
Vitamin K2 (as all-trans menaquinone-7)
100 mcg
Other ingredients: extra virgin olive oil, gelatin, glycerin, beeswax, purified water, maltodextrin, carob color.
Contains soybeans.
Dosage and Use
  • Take one (1) softgel daily with food, or as recommended by a healthcare practitioner.

If you are taking anticoagulant or antiplatelet medications, or have a bleeding disorder, consult with your healthcare provider before taking this product.

  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Friday, April 6, 2018

Thursday, April 5, 2018

Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis

. 2015; 12: 27.
Published online 2015 Jun 10. doi:  10.1186/s12970-015-0086-7
PMCID: PMC4472409
PMID: 26097441

Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis



Nitric oxide (NO) is endogenously synthesized from L-arginine and L-citrulline. Due to its effects on nitric oxide synthase (NOS), reduced glutathione (GSH) may protect against the oxidative reduction of NO. The present study determined the effectiveness of L-citrulline and/or GSH on markers indicative of NO synthesis in in vivo conditions with rodents and humans and also in an in vitro condition.


In phase one, human umbilical vein endothelial cells (HUVECs) were treated with either 0.3 mM L-citrulline, 1 mM GSH (Setria®) or a combination of each at 0.3 mM. In phase two, Sprague–Dawley rats (8 weeks old) were randomly assigned to 3 groups and received either purified water, L-citrulline (500 mg/kg/day), or a combination of L-citrulline (500 mg/kg/day) and GSH (50 mg/kg/day) by oral gavage for 3 days. Blood samples were collected and plasma NOx (nitrite + nitrate) assessed. In phase three, resistance-trained males were randomly assigned to orally ingest either cellulose placebo (2.52 g/day), L-citrulline (2 g/day), GSH (1 g/day), or L-citrulline (2 g/day) + GSH (200 mg/day) for 7 days, and then perform a resistance exercise session involving 3 sets of 10-RM involving the elbow flexors. Venous blood was obtained and used to assess plasma cGMP, nitrite, and NOx.


In phase one, nitrite levels in cells treated with L-citrulline and GSH were significantly greater than control (p < 0.05). In phase two, plasma NOx with L-citrulline + GSH was significantly greater than control and L-citrulline (p < 0.05). In phase three, plasma cGMP was increased, but not significantly (p > 0.05). However, nitrite and NOx for L-citrulline + GSH were significantly greater at 30 min post-exercise when compared to placebo (p < 0.05).


Combining L-citrulline with GSH augments increases in nitrite and NOx levels during in vitro and in vivo conditions.
Keywords: Nitric oxide, L-citrulline, L-arginine, Glutathione, Resistance exercise