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Toxicol Lett. 2006 Aug 20;165(2):149-55. Epub 2006 Apr 18.
17beta-hydroxy-5alpha-androst-1-en-3-one (1-testosterone) is a potent androgen with anabolic properties.
Friedel A, Geyer H, Kamber M, Laudenbach-Leschowsky U, Schänzer W, Thevis M, Vollmer G, Zierau O, Diel P.
SourceCenter for Preventive Doping Research, Institute of Cardiovascular Research and Sports Medicine, Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, 50927 Cologne, Germany.
AbstractSince the begining of the year 2005, the use of steroid precursors (prohormones) is illegal in the United States; nevertheless, there is still an enormous abuse of such substances. One of the most frequently misused steroids, often declared to be a prohormone, is 1-testosterone (17beta-hydroxy-5alpha-androst-1-en-3-one, 1-Testo). In this study, we have characterised molecular mechanisms of its action, determined its tissue specific androgenic and anabolic potency and investigated potential adverse effects. 1-Testo binds highly selective to the androgen receptor (AR) and has a high potency to stimulate AR dependent transactivation. In vivo an equimolar dose of 1-Testo has the same potency to stimulate the growth of the prostate, the seminal vesicles and the androgen sensitive levator ani muscle as the reference compound testosterone propionate (TP). Administration of 1-Testo, in contrast to TP, results in a significant increase of liver weight. Our results demonstrate that 1-Testo, even without being metabolised, is a very potent androgen. It binds selectively to the AR and transactivates AR dependent reporter genes. In vivo it has a high androgenic and anabolic potency and increases liver weight. In summary 1-Testo can be characterised as a typical anabolic steroid. It has to be assumed that consumption of this substance is associated with adverse side effects typical for this class of compounds. Therefore, a strict control of its ban is essential.
- [PubMed - indexed for MEDLINE]
From the manufacturers site:
|Serving Size: 1 Capsule|
|Servings Per Container: 60|
|Amount Per Serving|
1a-STERONE™† (3-enanthoxy-5alpha-androst-1-en-17-one ), Bergamottin, Naringin)
|**Daily Value not Established|
|Other Ingredients: Gelatin, Silica, Magnesium Stearate, Titanium Dioxide, FD&C Blue #1|
†1a-STERONE™ is a trademark of Redefine Nutrition.
Suggested Use: As a dietary supplement take 1 capsule twice daily with meals. Take first serving of FINAFLEX 1-ALPHA™ immediately upon rising or with breakfast. Take second serving of 1-ALPHA™ 8-12 hours later. For extreme results use 2 bottles of 1-ALPHA™ consecutively over a 40-60 day period. Do not use 1-ALPHA™ for more than 60 days consecutively. Take at least 60 days off before starting another cycle of 1-ALPHA™. Follow cycle of 1-ALPHA™ with FINAFLEX PCT REVOLUTION™ to ensure proper Post Cycle Therapy.