If a first time user wanted to use 600 mg of cypionate or
enanthate per week he would inject 300 mg on Tuesday and another 300 mg on
Saturday each week for 10 weeks.
12
men participated in the 300 mg group and 13 men in the 600 mg group.
600mg of
Testosterone a week for 20 weeks resulted in the following benefits. Increased
fat free mass, muscle strength, muscle power, muscle volume, hemoglobin and
IGF-1.
The same 600 mg
administration resulted in 2 side effects. HDL cholesterol was negatively
correlated and 2 men developed acne.
The normal
range for total T in men is 241-827 ng/dl according to Labcorp and 260-1000
ng/dl according to Quest Laboratories. The normal range for IGF-1 is 81-225
according to Labcorp. Total T and IGF-1 levels were taken after 16 weeks and
resulted in the following;
Total
Testosterone
300 mg group-1,345 ng/dl a 691 ng increase from baseline
600 mg group-2,370 ng/dl a 1,737 ng increase from baseline
IGF-1
300 mg group-388 ng/dl a 74 ng increase from baseline
600 mg group-304 ng/dl a 77 ng increase from baseline
Body
composition was measured after 20 weeks.
Fat Free
Mass by underwater weighing
300 mg group-5.2kg (11.4lbs) increase
600 mg group-7.9kg (17.38lbs) increase
Fat Mass
by underwater weighing
300 mg group-.5kg (1.1lbs) decrease
600 mg group-1.1kg (2.42lbs) decrease
Thigh
Muscle Volume
300 mg group-84 cubic centimeter increase
600 mg group-126 cubic centimeter increase
Quadriceps
Muscle Volume
300 mg group-43 cubic centimeter increase
600 mg group-68 cubic centimeter increase
Leg Press
Strength
300 mg group-72.2kg (158.8lbs) increase
600 mg group-76.5kg (168.3lbs) increase
Leg Power
300 mg group-38.6 watt increase
600 mg group-48.1 watt increase
Hemoglobin
300 mg group-6.1 gram per liter increase
600 mg group-14.2 gram per liter increase
Plasma
HDL Cholesterol
300 mg group-5.7 mg/dl decrease
600 mg group-8.4 mg/dl decrease
Acne
300 mg group-7 of the 12 men developed acne
600 mg group-2 of the 13 men developed acne
There were no
significant changes in PSA or liver enzymes at any dose up to 600mg. However,
long-term effects of androgen administration on the prostate, cardiovascular
risk, and behavior are unknown. The study demonstrated that there is a dose
dependent relationship with testosterone administration. In other words the
more testosterone administered the greater the muscle building effects and
potential for side effects.
Pharmacokinetics of
Testosterone cypionate Injection
Source:
Schulte-Beerbuhl, 1980 Figure. Pharmacokinetics of 200mg Testosterone cypionate
injection. Source: Comparison of Testosterone, dihydrotestosterone, luteinizing
hormone, and follicle-stimulating hormone in serum after injection of
Testosterone enanthate or Testosterone cypionate. Schulte-Beerbuhl M, Nieschlag
E. Fertility and Sterility 33 (1980) 201-3.
Sample
cycle with ancillaries
Sunday
10mg Aromasin
Monday 10mg Aromasin/500iu HCG
Tuesday 10mg Aromasin/300mg Enanthate
Wednesday 10mg Aromasin
Thursday 10mg Aromasin
Friday 10mg Aromasin/500iu HCG
Saturday 10mg Aromasin/300mg Enanthate
I recommend the following PCT protocol for esters like Cypionate
and Enanthate;
While the aas
ester is clearing : 2500iu HCG every third day for 2 weeks. (You may use less
HCG if your testes are normal in size AND you have been using HCG on cycle,
i.e. 1,000iu HCG every third day.)
100/100/100/50
Clomid (50mg taken twice per day weeks 1-3 AFTER the aas ester clears)
20mg/20mg/20mg
Aromasin (20mg daily for 3 weeks)
3g Vit C every
day split in 3 doses
10g creatine
daily
References:
1.Testosterone dose-response relationships in
healthy young men;
2.Pharmacokinetics and Dose Finding of a Potent
Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
3.Low-Dose Human Chorionic Gonadotropin
Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced
Gonadotropin Suppression
4.Use of clomiphene citrate to reverse premature
andropause secondary to steroid abuse.
5.Changes in the Endocrinological Milieu After
Clomiphene Citrate Treatment for Oligozoospermia: The Clinical Significance of
the Estradiol/Testosterone Ratio as a Prognostic Value
6.Testicular steroidogenesis after human chorionic
gonadotropin desensitization in rats.
7.Effect of tamoxifen on GH and IGF-1 serum
level in stage I-II breast cancer patients
8.Treatment of gynecomastia with tamoxifen: A
double-blind crossover study
9.Role of testosterone/estradiol ratio in
predicting the efficacy of tamoxifen citrate treatment in idiopathic
oligoasthenoteratozoospermic men.
Abstract
Am J Physiol Endocrinol
Metab. 2001 Dec;281(6):E1172-81. Testosterone dose-response
relationships in healthy young men. Bhasin S(1), Woodhouse
L, ...
Full Text
ajpendo.physiology.org/content/281/6/E1172
1.
Dec 1, 2001 - Testosterone dose-response
relationships in healthy young men. Shalender Bhasin,
Linda Woodhouse, Richard Casaburi, Atam B. Singh, ...
Additional Resources:
Clomiphene increases free testosterone levels in men with ... - Nature
https://www.nature.com › international journal of impotence research › original research
Jul 15, 2003 - Secondary hypogonadism is more common than primary gonadal failure and is seen in chronic and acute illnesses. Although testosterone has ...
