Amazing Nutrition Berberine Plus 500 mg 120 Capsules - Supports immune system - Supports glucose metabolism - Aid in healthy weight management
Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree tumeric.
Berberine sends more nutrients to muscle and less to fat storage. This not only would be beneficial to bodybuilding but to anyone looking to store less fat, lose weight or control blood sugar.
Bodybuilders have traditionally handled this by staying low and slow carbohydrate the majority of the day with the exception of post workout. Fast or high glycemic carbs are only allowed post workout.
Stack with:
Glutamine
Yohimbine (avoid if blood pressure is an issue)
Sodium caprate
Resources:
Berberine on examine.com
Video:
Benefits of Berberine
Berberine supplement benefit,
side effects by Ray Sahelian, M.D.
Berberine on WebMD
Yohimbine & Berberine Protect From Death Due to LPS Intoxication; BCAAs Inhibit Serotonin Metabolism & Cause Anxiety, Tryptophan but not SSRIs Help; Sweet Tea Leaves Are PPAR-G Antagonists & Battle High Lipid + Leptin Levels
Fighting to Stay Lean? These 20+ Anti-Obesity Agents Have the Potential to Inhibit Fat Gain Right at the Cellular Level
Metabolism: Efficacy of berberine in patients with type 2 diabetes mellitus (Metformin)
Xing, H.; Ye, J.; Yin, J.Alternative Medicine Review
June, 2008. Vol.13,Iss.2;p.183
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
Cheng, Zhe; Cooney, Gregory J.; Gosby, Alison; Hu, Li-Hong; James, David E.; Kraegen, Edward W.; Li, Jia; Li, Jing-Ya; Miyoshi, Hiroyuki; Taketo, Makoto M.; To, Sabrina W.C.; Turner, Nigel; Ye, Ji-Ming.Diabetes
May, 2008. Vol.57,Iss.5;p.1414
Research Studies:
Cheng Z, Pang T, Gu M, et al. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim Biophys Acta. 2006 Nov;1760(11):1682-9.
Li H, Wang Y, Zhang H, Jia B, Wang D, et al. Yohimbine Enhances Protection of
Berberine against LPS-Induced Mouse Lethality through Multiple Mechanisms. PLoS
ONE. 2012; 7(12): e52863.
Lv, X.Y., Li, J., Zhang, M., Wang, C.M., Fan, Z., Wang, C.Y., Chen, L., 2010.
Enhancement of sodium caprate on intestine absorption and antidiabetic action of
berberine. AAPS.PharmSciTech. 11, 372–382
Zhanga M, Lvc X, Lia J, Menga Z, Wangd Q, Changa W, Lia W, Chena L. Sodium
caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting
hepatic gluconeogenesis. Molecular and Cellular Endocrinology. 16 August 2012
Brown PN, Roman MC. Determination of hydrastine and berberine in goldenseal raw
materials, extracts, and dietary supplements by high-performance liquid
chromatography with UV: collaborative study. J AOAC Int. 2008
Jul-Aug;91(4):694-701.
Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG,
Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat
diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent
mitochondrial biogenesis. Biochim Biophys Acta. 2012 Feb;1822(2):185-95.
Hu Y, Davies GE. Berberine increases expression of GATA-2 and GATA-3 during
inhibition of adipocyte differentiation. Phytomedicine. 2009 Sep;16(9):864-73.
doi: 10.1016/j.phymed.2009.03.002. Epub 2009 Apr 28.
Huang C, Zhang Y, Gong Z, Sheng X, Li Z, Zhang W, Qin Y. Berberine inhibits
3T3-L1 adipocyte differentiation through the PPARgamma pathway.
Biochem Biophys Res Commun. 2006;
348:571–578.
Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT,
et al. Berberine, a natural plant product, activates AMP-activated protein
kinase with beneficial metabolic effects in diabetic and insulin-resistant
states. Diabetes. 2006;55:2256–2264.
Liu Y, Lou SY, He YM. [Effects of berberine on cell proliferation, peroxisome
proliferation activated receptor gamma, CAAT/enhancer binding protein mRNA and
protein expression in 3T3-L1 pre-adipocytes]. Zhongguo Zhong Xi Yi Jie He Za
Zhi. 2008 Nov;28(11):1005-9.
Wang JM, Yang Z, Xu MG, Chen L, Wang Y, Su C, Tao J. Berberine-induced decline
in circulating CD31+/CD42- microparticles is associated with improvement of
endothelial function in humans.
Eur J Pharmacol.
2009;
614:77–83.
Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, Zeitz M, Fromm M, Schulzke JD.
TNFalpha-induced and berberine-antagonized tight junction barrier impairment via
tyrosine kinase, Akt and NFkappaB signaling. J Cell Sci. 2010 Dec 1;123(Pt
23):4145-55.
Gu L, Li N, Li Q, Zhang Q, Wang C, Zhu W, Li J. The effect of berberine in vitro
on tight junctions in human Caco-2 intestinal epithelial cells. Fitoterapia.
2009 Jun;80(4):241-8.
Li N, Gu L, Qu L, Gong J, Li Q, Zhu W, Li J. Berberine attenuates
pro-inflammatory cytokine-induced tight junction disruption in an in vitro model
of intestinal epithelial cells. Eur J Pharm Sci. 2010 Apr 16;40(1):1-8.
Niu L, Qiao W, Hu Z, Li N, Huang Q, Gong J, Li Q, Zhu W, Li J. Berberine
attenuates lipopolysaccharide-induced impairments of intestinal glutamine
transport and glutaminase activity in rat. Fitoterapia. 2011 Apr;82(3):323-30.
