Nutrient Partitioning with Indigo-3G® Cyanidin 3-glucoside (C3G)

Indigo-3G® - 90 capsules

Product description from the manufacturer.

·         Controls carbs to build muscle.

·         Maximizes nutrient uptake in muscle.

·         Releases and burns body fat.

·         Prevents the storage of fat.

Scientists have discovered a naturally occurring compound — called cyanidin 3-glucoside (C3G) — that has the ability to precisely control carbohydrates so that what you eat literally turns to muscle instead of fat. 

This might seem hard to believe, but research has proven C3G's effects on insulin signaling, selective insulin sensitivity, glucose and nutrient management, as well as its direct effect on fat and muscle cells, is extremely elaborate and precise. 

C3G literally makes your body function perfectly for building muscle mass without the fear of gaining fat, even while on a bulking diet, making the body-building process a whole new ballgame. No more depriving yourself of the optimal nutrition for building muscle because "your body can't handle the carbs" — because now it can. 

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



Research:

Matsukawa, et al, The Type II Diabetes-preventive Effect of Cyanidin-3-glucoside on Adipocytes, Journal of Development in Sustainable Agriculture, 11: 31-35, 2016

Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells.

Lipids Health Dis. 2012 Jan 13;11:10. doi: 10.1186/1476-511X-11-10. Guo H1, Liu G, Zhong R, Wang Y, Wang D, Xia M.

Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity.

J Sci Food Agric. 2011 Apr;91(6):1006-13. doi: 10.1002/jsfa.4275. Epub 2011 Feb 24. Wei X1, Wang D, Yang Y, Xia M, Li D, Li G, Zhu Y, Xiao Y, Ling W.

Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1.

J Nutr Biochem. 2012 Apr;23(4):349-60. doi: 10.1016/j.jnutbio.2010.12.013. Epub 2011 May 2. Guo H1, Xia M, Zou T, Ling W, Zhong R, Zhang W.

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice.

Biochem Pharmacol. 2007 Dec 3;74(11):1619-27. Epub 2007 Aug 10.

Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice.

J Nutr. 2003 Jul;133(7):2125-30.

Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation.

Biochem Pharmacol. 2008 Mar 15;75(6):1393-401. Epub 2007 Dec 3.

Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton.

Phytomedicine. 2009 May;16(5):406-15. Epub 2009 Mar 20.

Gene expression profile of isolated rat adipocytes treated with anthocyanins.

Biochim Biophys Acta. 2005 Apr 15;1733(2-3):137-47. Epub 2005 Jan 12.

Microarray profiling of gene expression in human adipocytes in response to anthocyanins.

Biochem Pharmacol. 2006 Apr 14;71(8):1184-97. Epub 2006 Feb 17.

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes.

Biochem Biophys Res Commun. 2004 Mar 26;316(1):149-57.

USPLabs AP (Anabolic Pump) | Genetic Equalizer

 

Get AP Today!

An Effective Anabolic For Increasing Muscle Mass And Fat Loss!

Voted #1 Nutrient Partitioning Agent!*"
WHY DO GENETIC FREAKS GAIN MUSCLE & GET SHREDDED SO EASILY?

It's very simple... their bodies are predisposed to process nutrients more efficiently, and this assists to shuttle nutrients to their muscle cells & away from their fat cells... so they are always jacked and ripped, no matter what they eat or do. They have almost perfect insulin sensitivity, nutrient partitioning ability and high rate of protein synthesis...

Basically, the bodies of genetic freaks tend-to promote a muscle-building, fat-burning anabolic state... While the rest of us spend our days in a muscle-wasting, fat-storing catabolic state, even if you eat protein every few hours and do everything right... It sucks, but it's the truth...

Not to worry, not all hope is lost...

There's a protein-transporter hormone called GLUT4 that lays dormant in the middle of every muscle and fat cell in your body. It just sits there minding its own business until it's activated by weight training, or dietary intake...

When GLUT4 is activated, it comes to the surface of the muscle cell and begins to suck in mass-building glucose like an industrial-sized vacuum!

This is better known as the "Post Workout Window Of Opportunity" - where all of the magic happens - as your body is in a super-anabolic state, absorbing nutrients, building muscle and burning fat. This is the only "window" the natural guy has. Mess this up and you don't have a prayer.

Unfortunately, even if you take a post-workout shake, GLUT4 only comes to the surface of the cell & remains active for a short period, and then it goes back into hibernation...

What if you could increase GLUT4 activation outside of the pathetically-short post-workout period?

THERE MAY BE HOPE FOR HARDGAINERS...

As a Hardgainer, one reason it's difficult to put on muscle mass is because nutrients have a hard time being delivered to your muscle cells. It's that simple. The reality is your muscle cells may only be getting a few measly grams of protein, even when you take in large amounts. The majority of that protein (and other nutrients) never reach your muscle tissue.

THAT'S why gaining muscle mass is nearly impossible for you!

You see, hardgainers can get very little GLUT4 activation, so you almost never have a window to gain muscle, even post-workout! No wonder those pre, intra & post workout shakes aren't doing jack for you!

Put On Bodyfat Easily? WOULDN'T IT BE GREAT TO GET RIPPED - WHILE STAYING BIG & STRONG!

Unlike the genetic freaks who get all of their nutrients delivered to their muscle cells - OR the hardgainers who have difficulty getting nutrients delivered - most of the nutrients you consume, especially carbs, get stored right into your fat cells...

While, at least you can get bigger & stronger... you don't have as much head-turning muscle definition as you'd like... Listen, I'm not trying to come down on you, just giving you the absolute truth so you can do something about it!

So, wouldn't it be great if nutrients could be shuttled into muscle cells and away from fat cells... [4]

THAT my friend, is the power of GLUT4 activation...

And, we believe, based upon studies in animal models and animal cells/tissue [4] that there’s a compound that has demonstrated the ability to do that …

A constituent of a key ingredient in Anabolic-Pump has been shown in vitro (utilizing animal skeletal muscle) to increase GLUT4 up to threefold or more!

We believe, based upon studies in animal models and animal cells/tissue, this key constituent may activate GLUT4 in muscle cells—allowing carbohydrates to be delivered to muscle cells . [1-5 ]

Give yourself a shot. After all you spend so much time training, eating right, educating yourself…Why wouldn't you stack the cards in your favor? Honestly, there's no good reason not to…

Fact is, the longer period of time GLUT4 is activated, the better chance you have at developing the physique you want. This is your only shot at being on the same playing field as the freaks...

You owe it to yourself to give something with such great potential a shot. After all you spend so much time training, eating right, educating yourself...Why wouldn't you want to stack the cards in your favor? Honestly, there's no good reason not to...

Best,

USPlabs Ultra Premium Supplements

P.S. To truly maximize the result of any supplement, you must combine with proper nutrition & exercise plans. Feel free to visit our forums for information.

P.P.S. Anabolic-Pump is really easy to use. Simply take 1 capsule 15-20 minutes before a meal 2-3 times per day!

References

Lee YS, Kim WS, Kim KH, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. 2006 Aug;55(8):2256-64.
Bova S, Padrini R, & Goldman WF. On the mechanism of vasodilating action of berberine: possible role of inositol lipid signaling system. J Pharmacol & Experimental Therapeutics 1992; 261:318-323.
Baron AD, Clark MG. Role of blood flow in the regulation of muscle glucose uptake. Annu Rev Nutr. 1997;17:487-99
Cheng Z, Pang T, Gu M, et al. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim Biophys Acta. 2006 Nov;1760(11):1682-9.
Low SY, Rennie MJ, Taylor PM. Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume. J Physiol. 1996 Sep 1;495 ( Pt 2):299-303.

Nutrition Facts † Serving Size 1 Capsule
	Serving	% DV
Proprietary Blend	750 mg	-
Proprietary Blends
Proprietary Blend (Phellodendron (bark) extract, crape myrtle (lagerstroemia speciosia)(stem) extract)
Ingredients: Gelatin, corn starch, magnesium stearate, yellow 5, red 40.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. †Nutrition Facts are a simulation of the product's "Nutrition Label". For the actual Nutrition Label please refer to the product packaging.

Directions

As a dietary supplement take 1 cap twice daily, 15-20 minutes before carbohydrate containing meals. Each dose should be at least 4 hours apart.

Warnings

This product in only intended to be consumed by healthy adults, 18 years of age or older, Pregnant or nursing women should no use this product. Consult your health care provider before using this product, especially if you are taking a prescription, or over the counter medication, dietary supplement product or if you have any pre-existing medical condition including but not limited to high blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAO-B inhibitor or any other medication. Discontinue use and immediately consult your health care professional if you experience any adverse reaction to this product. Do not use if safety seal is broken or missing. Keep out of reach of children.

#MondayMotivation; get #Jack3d the future is worth the right http://t.co/cfWuNOy8IL pic.twitter.com/CT1ijAPwyN
— USPlabs® (@USPlabs) May 5, 2014

Ipriflavone: The anabolic isoflavone that you probably haven't heard of.

Used by Hungarians and brought to the U.S. by Patrick Arnold, Ipriflavone has gained significant attention in the strength training community.

Ipriflavone is thought to increase protein synthesis for building muscle mass. For that reason alone this could be a valuable supplement for the hardgainer. In addition, it supports bone formation,  healthy cholesterol levels and nitrogen retention.

Look to dose at 500 - 1,200 mg per day with meals. Ipriflavone cannot be used by the body on an empty stomach. 8 weeks on. 8 weeks off.

Excerpt from Animal Natural Anabolics

Due to its anabolic properties, ipriflavone can selectively increase fat-free lean mass. Like its cousin methoxyisoflavone, ipriflavone can do so via anabolism: increasing nitrogen retention, sparking protein synthesis, reducing protein breakdown (via cortisol inhibition), and by promoting nutrition-partitioning actions. With respect to nutrition-partitioning, studies have recorded up to 20% gains in weight from ipriflavone use, even with the same caloric intakes. According to pharmocokinetic studies, oral administration of ipriflavone is quickly absorbed and metabolized in the liver.

Other Articles:
Natural Anabolics - Article Details

Ipriflavone information,benefits,side effects,dose

List of Glucose Disposal Agents - Move more glucose into muscle

Glucose disposal agents mean more nutrients to muscle and less to fat. Here's a list of some of the most widely used.

Berberine
Human and animal research demonstrates that 1500mg of berberine, taken in three doses of 500mg each, is equally effective as taking 1500mg of metformin or 4mg glibenclamide, two pharmaceuticals for treating type II diabetes.

Gymnema Sylvestre
Gymnema Sylvestre found in India, Africa, and Australia. It contains 12 saponins forming the active chemical is gymnemic acid which has a potent effect on insulin sensitivity and glucose disposal. Gymnema also is suspected to  also regenerate damaged pancreatic beta cells. These cells are the only site of insulin production in the body. 

Alpha Lipoic acid
ALA is the universal antioxidant naturally found in minute amounts in meats, heart, kidney, liver, and some fruits in vegetables. It's antioxidant capabilities can neutralize hydroxyl radicals and singlet oxygen, two of the most destructive free radicals. ALA can also help to regenerate other antioxidants such as vitamins C and E.

Vanadyl Sulfate
This “Insulin mimetic” can activate glucose uptake without insulin. It also up regulates glycogen synthesis pumping up your muscles.

Cinnamon Extract
Cinnamon both supports insulin and also has insulin mimetic properties. It supports the uptake of glucose and can increase GLUT4 levels.  GLUT4 is the insulin-regulated glucose transporter found in adipose (fat) tissues and muscle.

Chromium Picolinate
Chromium is an essential trace nutrient needed for carbohydrate metabolism. Chromium is another agent that can directly affect insulin sensitivity by activating GLUT4.

Biotin
This water-soluble B vitamin is important for carbohydrate metabolism. Biotin was included in The Ultimate GDA as more of an insurance plan, based on some research that suggests that ALA may actually compete with biotin for absorption, possibly causing a biotin deficiency. There is also evidence that biotin may work synergistically with chromium to improve glucose metabolism (37).

Bitter Melon
Bitter Melon contains compounds that activate a protein called AMPK that regulates fuel metabolism and enabling glucose uptake. These are processes which are impaired in diabetics.

Phellodendron amurense
"Amur Cork Tree" contains berberine which has been shown to have anti-diabetic activity.  While early indications are outstanding more research needs to be done. Berberine is also found in Oregon Grape, Barberry and Goldenseal.

Vanadyl Sulfate
Vanadyl sulfate is thought to help muscle cells uptake glucose. Food sources tend to be best but supplements are also an option. Food sources rich in vanadium include pepper, dill, radishes, eggs, vegetable oils, buckwheat and oats. Vanadyl supplemental use should be approached with caution.
BMOV (Bis-Malto-Oxovanadium)  is an organic form of the mineral vanadium.

Vinegar
Apple cider vinegar has long been valued for its nutritive properties as a folk remedy and it's affects on blood glucose levels has been clinically researched to be positive.

Fenugreek
Fenugreek appears to be able to slow down the rate at which sugars are absorbed into the body. This is greatly beneficial in regulating blood sugar levels. Additionally, studies indicate that 4-hydroxyisoleucine (an amino acid) found in fenugreek may induce or promote the production of insulin when blood sugar levels are elevated.

Cissus quadrangularis
Has lots of anecdotal information about it's ability to cause significant reductions in weight and blood glucose levels. More research needs to be done to verify these claims. If you want more information read Timothy Ferriss' Four Hour Body.

Magnolia officinalis
Magnolia bark is not a glucose disposal agent but a supporting agent in the "battle of the bulge". It is used as a general anti-stress and anti-anxiety agent to help control cortisol levels.

Banaba
A tree native to Southeast Asia has been used in traditional medicine in the Phillipines as a treatment for diabetes. The leaves are high in corosolic acid, which has been shown to improve glucose control in human and animal studies. It appears to do this by stimulating glucose uptake in muscle cells.

Amazing Nutrition Berberine Plus 500 mg 120 Capsules - Supports immune system - Supports glucose metabolism - Aid in healthy weight management

Aggressive Strength Natural Testosterone Booster

More Muscle - Nutrient Partioning with Berberine - It has been compared to Metformin

Amazing Nutrition Berberine Plus 500 mg 120 Capsules - Supports immune system - Supports glucose metabolism - Aid in healthy weight management
Berberine is a chemical found in several plants including European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree tumeric.

Berberine sends more nutrients to muscle and less to fat storage. This not only would be beneficial to bodybuilding but to anyone looking to store less fat, lose weight or control blood sugar.

Bodybuilders have traditionally handled this by staying low and slow carbohydrate the majority of the day with the exception of post workout. Fast or high glycemic carbs are only allowed post workout.

Stack with:

Glutamine
Yohimbine (avoid if blood pressure is an issue)
Sodium caprate

Resources:

Berberine on examine.com

Video: Benefits of Berberine

Berberine supplement benefit, side effects by Ray Sahelian, M.D.

Berberine on WebMD

Yohimbine & Berberine Protect From Death Due to LPS Intoxication; BCAAs Inhibit Serotonin Metabolism & Cause Anxiety, Tryptophan but not SSRIs Help; Sweet Tea Leaves Are PPAR-G Antagonists & Battle High Lipid + Leptin Levels

Fighting to Stay Lean? These 20+ Anti-Obesity Agents Have the Potential to Inhibit Fat Gain Right at the Cellular Level

Metabolism: Efficacy of berberine in patients with type 2 diabetes mellitus (Metformin)
Xing, H.; Ye, J.; Yin, J.Alternative Medicine Review
June, 2008. Vol.13,Iss.2;p.183

Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
Cheng, Zhe; Cooney, Gregory J.; Gosby, Alison; Hu, Li-Hong; James, David E.; Kraegen, Edward W.; Li, Jia; Li, Jing-Ya; Miyoshi, Hiroyuki; Taketo, Makoto M.; To, Sabrina W.C.; Turner, Nigel; Ye, Ji-Ming.Diabetes
May, 2008. Vol.57,Iss.5;p.1414

Research Studies:
Cheng Z, Pang T, Gu M, et al. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim Biophys Acta. 2006 Nov;1760(11):1682-9.

Li H, Wang Y, Zhang H, Jia B, Wang D, et al. Yohimbine Enhances Protection of Berberine against LPS-Induced Mouse Lethality through Multiple Mechanisms. PLoS ONE. 2012; 7(12): e52863.

Lv, X.Y., Li, J., Zhang, M., Wang, C.M., Fan, Z., Wang, C.Y., Chen, L., 2010. Enhancement of sodium caprate on intestine absorption and antidiabetic action of berberine. AAPS.PharmSciTech. 11, 372–382

Zhanga M, Lvc X, Lia J, Menga Z, Wangd Q, Changa W, Lia W, Chena L. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Molecular and Cellular Endocrinology. 16 August 2012

Brown PN, Roman MC. Determination of hydrastine and berberine in goldenseal raw materials, extracts, and dietary supplements by high-performance liquid chromatography with UV: collaborative study. J AOAC Int. 2008 Jul-Aug;91(4):694-701.

Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, Jones JG, Sinclair DA, Palmeira CM, Rolo AP. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta. 2012 Feb;1822(2):185-95.

Hu Y, Davies GE. Berberine increases expression of GATA-2 and GATA-3 during inhibition of adipocyte differentiation. Phytomedicine. 2009 Sep;16(9):864-73. doi: 10.1016/j.phymed.2009.03.002. Epub 2009 Apr 28.

Huang C, Zhang Y, Gong Z, Sheng X, Li Z, Zhang W, Qin Y. Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway. Biochem Biophys Res Commun. 2006;348:571–578.

Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes. 2006;55:2256–2264.

Liu Y, Lou SY, He YM. [Effects of berberine on cell proliferation, peroxisome proliferation activated receptor gamma, CAAT/enhancer binding protein mRNA and protein expression in 3T3-L1 pre-adipocytes]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Nov;28(11):1005-9.

Wang JM, Yang Z, Xu MG, Chen L, Wang Y, Su C, Tao J. Berberine-induced decline in circulating CD31+/CD42- microparticles is associated with improvement of endothelial function in humans. Eur J Pharmacol. 2009;614:77–83.

Amasheh M, Fromm A, Krug SM, Amasheh S, Andres S, Zeitz M, Fromm M, Schulzke JD. TNFalpha-induced and berberine-antagonized tight junction barrier impairment via tyrosine kinase, Akt and NFkappaB signaling. J Cell Sci. 2010 Dec 1;123(Pt 23):4145-55.

Gu L, Li N, Li Q, Zhang Q, Wang C, Zhu W, Li J. The effect of berberine in vitro on tight junctions in human Caco-2 intestinal epithelial cells. Fitoterapia. 2009 Jun;80(4):241-8.

Li N, Gu L, Qu L, Gong J, Li Q, Zhu W, Li J. Berberine attenuates pro-inflammatory cytokine-induced tight junction disruption in an in vitro model of intestinal epithelial cells. Eur J Pharm Sci. 2010 Apr 16;40(1):1-8.

Niu L, Qiao W, Hu Z, Li N, Huang Q, Gong J, Li Q, Zhu W, Li J. Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat. Fitoterapia. 2011 Apr;82(3):323-30.

Banaba Leaf Extract: An insulin mimicker.

Used in the Philippines as traditional medicine to treat diabetes and kidney diseases, the leaves appear to act in a similar manner to insulin by activating insulin receptors. One of the main ingredients responsible for this action is corosolic acid.

Try 30-50mg banaba leaf extract standardized for corosolic acid with your post-workout shake or with you biggest carbohydrate containing meal.

Or anytime with carbs and creatine. Banaba and other insulin-boosting supplements like gymnema and alpha lipoic acid work by either increasing the release of insulin from the pancreas or enhancing its effects at the muscle. Taking any of these post-workouts boosts insulin's action at the muscles without promoting insulin's action on fat storage.

ALPHA-LIPOIC ACID (ALA): The Universal Antioxidant

Alpha-lipoic acid (ALA) is a powerful antioxidant. It's called the universal antioxidant because seems to help prevent certain kinds of cell damage in the body, and also restores vitamin levels such as vitamin E and vitamin C.

Bodybuilders love it because it improves muscle glucose and creatine uptake when consumed with simple carbs like dextrose.

In addition, ALA is used in some fat-loss products because it reduces the amount of insulin released when carbs are eaten. This increases fat burning and reduces hunger.

 

The Flex magazine recommended dosage is as follows:

• For increased creatine uptake; 500-600mg with 2-5g of creatine.
• For fat loss and antioxidant protection: 100-300mg two to three times per day

R-Lipoic Acid the better form?
Lipoic acid helps protect against oxidative stress generated by high glucose levels. Alpha-lipoic acid consists of two different forms (isomers) that have vastly different properties. The “R” form is the biologically active component (native to the body) that is responsible for lipoic acid’s phenomenal antioxidant effect.

Sources:
University of Maryland Medical Center

Webmd ALA page

Studies:
Androne L, Gavan NA, Veresiu IA, Orasan R. In vivo effect of lipoic acid on lipid peroxidation in patients with diabetic neuropathy. In Vivo. 2000;14(2):327-330.
Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol. 2003;149:841-9.
Berkson BM. A conservative triple antioxidant approach to the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic acid), silymarin, and selenium: three case histories. Med Klin. 1999;94 Suppl 3:84-89.
Clark WM, Rinker LG, Lessov NS, Lowery SL, Cipolla MJ. Efficacy of antioxidant therapies in transient focal ischemia in mice. Stroke. 2001;32(4):1000-1004.
Faust A, Burkart V, Ulrich H, et al. Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice. Int J Immunopharmacol. 1994;16:61-66.
Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. 2001;6(2):141-166.
Hruby K, Csomos G, Fuhrmann M, Thaler H. Chemotherapy of Amanita phalloides poisoning with intravenous silibinin. Hum Exp Toxicol. 1983;2(2):183-195.
Lynch MA. Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue. Nutr Neurosci. 2001;4(6):419-438.
Melhem MF, Craven PA, Derubertis FR. Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol. 2001;12:124-133.
Melhem MF, Craven PA, Liachenko J, et al. Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. J Am Soc Nephrol. 2002;13:108-116.
Monograph:Alpha-Lipoic Acid. Altern Med Rev. 1998;3(4):308-311.
Nagamatsu M, Nickander KK, Schmelzer JD,et al. Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care. 1995;18:1160-1167.
Packer L, Kraemer K, Rimbach G. Molecular aspects of lipoic acid in the prevention of diabetes complications. Nutrition. 2001;17(10):888-895.
Packer L, Tritschler HJ, Wessel K. Neuroprotection by the metabolic antioxidant alpha-linoic acis. Free Radic Biol Med. 1997;22:359–378.
Packer L, Witt EH, Tritschler HJ. Alpha-lipoic acid as a biological antioxidant. Free Rad Bio Med. 1995;19(2):227-250.
Panigrahi M, Sadguna Y, Shivakumar BR, Kolluri SV, Roy S, Packer L, Ravindranath V. Alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats. Brain Res. 1996;717(1-2):184-188.
Rakel D. Rakel Integrative Medicine, 2nd ed. Philadelphia, Pa: Elsevier Inc. 2008;84.
Segermann J, Hotze A, Ulrich H, et al. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung. 1991;41:1294-1298.
Ziegler D, Ametov A, Barinov A, et al. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: The SYDNEY 2 trial. Diabetes Care. 2006;29:2365-70.
Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997;46 (suppl 2):S62-66.
Ziegler D, Reljanovic M, Mehnert H, Gries FA. Alpha-lipoic acid in the treatment of diabetic polyneuropathy in Germany: current evidence from clinical trials. Exp Clin Endocrinol Diabetes. 1999; 107:421-430.

Vaporize Your Fat Stores with MAN Vaporize. Non-stimulant Fat Burner.

  The cool thing about non-stimulant fat burners is that you can add them to your current stack to enhance the cutting process.

MAN Vaporize is one such product. Vaporize combines sesamin with fish oil to help you meet your lean goal.

The below is from Muscle and Fitness:

SESAMIN IS A LIGNAN found in sesame oil that can offer potent antioxidant activity and aid fat loss. Sesamin itself has no antioxidant activity; however, in the liver it gets converted to an active form that acts like a powerful antioxidant. In fact, one study showed that males who took sesamin before exercise had considerably less oxidative damage after exercise as compared to controls and subjects who took Vitamin E before exercise. Not only does the active form scavenge damaging free radicals, but it also decreases fatty acid production and increases fat breakdown. That adds up to greater fat loss when sesamin is taken regularly.

One of the mechanisms by which scientists believe sesamin works is by altering genes that increase the production of metabolic enzymes and other important proteins involved in producing body fat and burning fat for energy in the body. An effective dose of sesamin appears to be 500-1,000 mg taken 2-3 times a day with food. You can find a potent form of sesamin in Sesamin by Scivation (scivation.com).
 

Source:

HUNGRY LIKE THE WOLF. Authors: Stoppani, Jim Source: Joe Weider's Muscle & Fitness; Feb 2006, Vol. 67 Issue 2, p 256-256

The below is from the manufacturer:

VAPORIZE™ represents a sensation so remarkable you have to experience it to believe it. Comprised of a revolutionary nutritional breakthrough; sesamin, a gift found in the husks of sesame seeds and in the bark and fruit of certain plant species. VAPORIZE™ sets free a body fat reducing phenomenon so extraordinary it defies description! Recognized as a lignan, sesamin found in VAPORIZE™ from MAN Sports, also supports liver and kidney health, supports healthy cholesterol levelsalready within the normal range and posses potent Antioxidant activity by increasing the absorption, use and recycling of Vitamin E.* Its tremendous fat oxidizing phenomenon is believed to be attributed to augmenting the release of potent thermogenic enzymes through optimized liver function.* Fascinatingly more, sesamin's potent fat and health promoting effects are further amplified when used in conjunction with essential fatty acids.* And that is why VAPORIZE™ also integrates BIG-FISH™, a potent 50% EPA/DHA fish oil matrix. As a premium source of EFA's, BIG-FISH™, works in tandem with sesamin in VAPORIZE™ to initiate a fat incinerating and health promoting supplement!*


The Highlights

• Radically reduces body fat through a process called fat oxidation*
• Inhibits lipogenic (fat storing) gene expression of several different fat storing enzymes*
• Provides powerful anti-oxidant properties*
• Supports healthy cholesterol levels already within the normal range*
• Supports healthy liver and kidney function*
• Increases insulin sensitivity and acts as a nutrient partitioner*
• Stacks well with Scorch, PUFA's, Flax lignans, and bioisomer-specific CLA for more dramatic and effective bodyfat reducing and health promoting properties.*

Sesamin

Sesamin is a lignan (a lignan is a chemical compound known as a phytoestrogen) and activates the Peroxisome Proliferator-Activator Receptor Alpha (PPAR alpha).* There are 3 different classes of PPAR's:

1. Alpha - expressed in kidney, heart, muscle, adipose tissue, and others.
2. Gamma - though transcribed by the same gene, this PPAR exists in three forms (y-1 (expressed in virtually all tissues), y-2 (expressed primarily in fat tissue), y-3 (expressed in macrophages, intestines and white adipose tissue).
3. Delta - expressed in many tissues but markedly in brain, adipose tissue and skin.

PPAR's are nuclear receptors that play major roles in fat metabolism, cellular energy balance and insulin sensitivity. Basically they are small complexes that have major impact on many systems in our body and many systems that contribute to fat loss and nutrient usage/expenditure/storage. The PPAR alpha receptors can be found expressed in the muscle, liver, and kidneys, and is specifically involved in the transcription of the genes involved in the beta-oxidation (burning) of fatty acids and lipogenesis (the storing of fat). As such, sesamin does two significant things in regards to weight control/fat loss.

It produces the phenomenon known as fat oxidation by augmenting the release of potent thermogenic enzymes through optimized liver function.* Meaning it helps increase the rate at which fat gets converted to energy.* It inhibits the function of fat storing enzymes.* Sesamin can alter metabolism to be one that preferentially utilizes fat as an energy source as well as foil its storage.*

Another thing of importance to the war on weight loss is that PPAR alpha activation (of which sesamin is extremely potent) also increases uncoupling-proteins (UCPs).* What this means is that an increase in UCPs would increase the calories needed to produce the same amount of energy. In other words sesamin increases the rate and capacity at which cells can vaporize fat.*

BIG-FISH™

BIG-FISH™ is a 50% EPA/DHA essential fatty acids blend which are known to have numerous health benefits. Among the proven health promoting properties of EPA and DHA are cardiovascular health, healthy blood cholesterollevels that are already within the normal range, support healthy joints and bodyfat reduction.* EPA and DHA also work in tandem with sesamin in activation of PPAR alpha and as such amplify the fat burning and health promoting properties of sesamin.*

Scientific References:

1. J Plant Physiol. 2005 Jul;162(7):834-43. Beyond vitamin E supplementation: an alternative strategy to improve vitamin E status. Department of Food Science, Swedish University of Agricultural Sciences, Box 7051, 750 07 Uppsala, Sweden.
2. Akimoto K., et al. 1993. Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann Nutr Metab. ;37(4):218-24.
3. Ashakumary L., et al. 1999. Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat. Metabolism. Oct;48(10):1303-13.
4. Fukuda N, et al. 1999. Effect of dietary sesamin on metabolic fate of an exogenous linolelaidic acid in perfused rat liver. J Nutr Sci Vitaminol (Tokyo). Aug;45(4):437-48
5. J Nutr Sci Vitaminol (Tokyo). 2002 Oct;48(5):405-9. Combined effects of dietary conjugated linoleic acid and sesamin triacylglycerol and ketone body production in rat liver.Sakono M, Yuji K, Miyanaga F, Tamaru S, Fujita M, Fukuda N, Tsutsumi K, Iwata T, Kasai M, Sugano M.
6. Hirose N., et al. 1991. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J. Lipid Res. Vol 32, 629-638.
7. Ide T., et al. 2001. Sesamin, a sesame lignan, decreases fatty acid synthesis in rat liver accompanying the down-regulation of sterol regulatory element binding protein-1. Biochim Biophys Acta. Nov 30;1534(1):1-13.
8. Ide T., et al. 2003. Sesamin, a Sesame Lignan, as a Potent Lipid-Lowering Food Component. JARQ 37 (3), 151 - 158.
9. Ide T. 2004. Interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. Biochim Biophys Acta. Jun 1;1682(1-3):80-91.
10. Lemcke-Norojarvi M, Kamal-Eldin A, Appelqvist LA, Dimberg LH, Ohrvall M, Vessby B. Corn and sesame oil increase serum gamma-tocopherol concentrations in healthy Swedish women. J Nutr. 2001 Apr;131(4):1195-201.
11. Evans, B. A. J., Griffiths, K., Morton, M. S., J Endocrinol (1995). Vol. 147 pp. 295…quot;302.
12. Circulation. 2003 Apr 1;107(12):1586-91. Epub 2003 Mar 10. Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica. Baylin A, Kabagambe EK, Ascherio A, Spiegelman D, Campos H
13. Metabolism. 2002 Oct;51(10):1253-60. Effect of alpha-linolenic acid-rich Camelina sativa oil on serum fatty acid composition and serum lipids in hypercholesterolemic subjects. Karvonen HM, Aro A, Tapola NS, Salminen I, Uusitupa MI, Sarkkinen ES.

USPLabs AP - Nutrient Partitioning - Send More Nutrients to Muscle and Less to Fat.

Simply put the goal of nutrient partitioning supplements is to send more nutrients to muscle and less to fat storage. This not only would be beneficial to bodybuilding but to anyone looking to store less fat.

Bodybuilders have traditionally handled this by staying low and slow carbohydrate the majority of the day with the exception of post workout. Fast or high glycemic carbs are only allowed post workout.

This is done since the fast carbohydrates fill the blood stream quickly with sugar. The body needs to rid the blood of the sugar so insulin is secreted to shuttle the sugars and other nutrients present in the blood into both fat and muscle storage. Working out depletes muscle of its own sugar stores, glycogen, which gives muscle preferential treatment to get those sugars replaced.

This is why the 30 - 45 minutes post-workout is called "anabolic window". The creatine and protein are shuttled into muscle with the help of fast carbs and insulin.

Nutrient partitioning agents are supportive of the whole process. It has been suggested that hardgainers can really benefit from these supplements.

Here are some products you can try to elevate your muscle gains.

References

1. Lee YS, Kim WS, Kim KH, et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects. Diabetes. 2006 Aug;55(8):2256-64.
2. Bova S, Padrini R, & Goldman WF. On the mechanism of vasodilating action of berberine: possible role of inositol lipid signaling system. J Pharmacol & Experimental Therapeutics 1992; 261:318-323.
3. Baron AD, Clark MG. Role of blood flow in the regulation of muscle glucose uptake. Annu Rev Nutr. 1997;17:487-99
4. Cheng Z, Pang T, Gu M, et al. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim Biophys Acta. 2006 Nov;1760(11):1682-9.
5. Low SY, Rennie MJ, Taylor PM. Modulation of glycogen synthesis in rat skeletal muscle by changes in cell volume. J Physiol. 1996 Sep 1;495 ( Pt 2):299-303.