Showing posts with label Androgenic. Show all posts
Showing posts with label Androgenic. Show all posts

Tuesday, November 6, 2018

Androgenic responses to resistance exercise: effects of feeding and L-carnitine.

2006 Jul;38(7):1288-96.

Androgenic responses to resistance exercise: effects of feeding and L-carnitine.

Erratum in

  • Med Sci Sports Exerc. 2006 Oct;38(10):1861.

Abstract

PURPOSE:

The purpose of this investigation was to determine the effects of 3 wk of L-carnitine L-tartrate (LCLT) supplementation and post-resistance-exercise (RE) feeding on hormonal and androgen receptor (AR) responses.

METHODS:

Ten resistance-trained men (mean+/-SD: age, 22+/-1 yr; mass, 86.3+/-15.3 kg; height, 181+/-11 cm) supplemented with LCLT (equivalent to 2 g of L-carnitine per day) or placebo (PL) for 21 d, provided muscle biopsies for AR determinations, then performed two RE protocols: one followed by water intake, and one followed by feeding (8 kcal.kg body mass, consisting of 56% carbohydrate, 16% protein, and 28% fat). RE protocols were randomized and included serial blood draws and a 1-h post-RE biopsy. After a 7-d washout period, subjects crossed over, and all experimental procedures were repeated.

RESULTS:

LCLT supplementation upregulated (P<0.05) preexercise AR content compared with PL (12.9+/-5.9 vs 11.2+/-4.0 au, respectively). RE increased (P<0.05) AR content compared with pre-RE values in the PL trial only. Post-RE feeding significantly increased AR content compared with baseline and water trials for both LCLT and PL. Serum total testosterone concentrations were suppressed (P<0.05) during feeding trials with respect to corresponding water and pre-RE values. Luteinizing hormone demonstrated subtle, yet significant changes in response to feeding and LCLT.

CONCLUSION:

In summary, these data demonstrated that: 1) feeding after RE increased AR content, which may result in increased testosterone uptake, and thus enhanced luteinizing hormone secretion via feedback mechanisms; and 2) LCLT supplementation upregulated AR content, which may promote recovery from RE.



Monday, July 17, 2017

Increase Muscle by Increasing Testosterone Androgen Receptors




ALLMAX L-CARNITINE L-TARTRATE, 120 Capsules Supplying 500mg L-Carnitine, Vegan and Gluten Free Dietary Supplement

Researchers and scientists at the University of Connecticut's Human Performance Laboratory tested the effects of L-Carnitine on its ability to enhance free-testosterone utilization. In the 21-day human clinical study, L-Carnitine dosed at 2 grams per day increased the number of androgen receptors compared to results produced by a placebo group.


Study:

Androgenic responses to resistance exercise: effects of feeding and L ...

https://www.ncbi.nlm.nih.gov/pubmed/16826026
by WJ Kraemer - ‎2006 - ‎Cited by 117 - ‎Related articles

Androgenic responses to resistance exercise: effects of feeding and L-carnitine. ... PURPOSE: The purpose of this investigation was to determine the effects of 3 wk of L-carnitine L-tartrate (LCLT) supplementation and post-resistance-exercise (RE) feeding on hormonal and androgen receptor (AR) responses.


Product description:

ALLMAX introduces 100% Pure L-Carnitine L-Tartrate (LCLT), one of the world's most bio-available forms of L-Carnitine supplementation.

Stimulant-Free Fat Metabolizer: L-Carnitine is essential for transporting long-chain fats into the cell (mitochondria). L-Carnitine taps into your fat supply and may provide support to burn it as fuel, resulting in increased energy. Without L-Carnitine, these fats cannot be burned for energy and are instead shunted to stored body fat.*



Supporting Information: 
Two grams L-carnitine daily protects athletes' muscles 31.12.2015
L-Carnitine makes fasting easier and more effective 03.02.2015
L-Carnitine reduces ADHD symptoms 01.03.2014
L-Carnitine helps hair grow 17.02.2014
L-Carnitine gives football players the edge 21.11.2013
The anti-catabolic effect of a couple of grams of L-carnitine 02.10.2013
L-Carnitine helps centenarians build muscle mass 27.03.2012
Mix of propionyl-L-carnitine and L-arginine improves erection 15.12.2011
L-Carnitine plus carbohydrates helps endurance athletes 14.10.2011
L-Carnitine makes Alli weight loss even more effective 17.02.2011
Weight loss with sibutramine goes faster when L-carnitine is added15.02.2011
Glycine Propionyl-L-Carnitine as an NO booster 03.10.2010
L-Carnitine-L-Tartrate restores muscles after training 24.09.2010
Carnitine plus a meal boosts post-workout testosterone uptake 10.09.2010
Fat burner carnitine needs carbohydrates 06.05.2009


Types of L-Carnitine

  • L-Carnitine L-Tartrate (LCLT): Best for muscle recovery and improved function of your androgen receptors. Another study showed that LCLT enhanced the oxygenation of post-workout muscle tissue, which improved it during sprint work.
  • Acetyl L-Carnitine (ALCAR):has been shown to enhance cognitive function.
  • Glycine Propionyl L-Carnitine (GPLC): Has been shown to improve blood flow and used for a nitric oxide boost
  • Propionyl L-Carnitine (PLCAR): Best for metabolism and fat burning
Source:
Increase Androgen Receptors for Pack on More Muscle by Infinite Labs



Wednesday, April 23, 2014

SuppVersity - Nutrition and Exercise Science for Everyone: Colostrum Maintains Testosterone, Cortisol and Hea...

SuppVersity - Nutrition and Exercise Science for Everyone: Colostrum Maintains Testosterone, Cortisol and Hea...: Legal gear fresh from the udder? If it works for cyclist, it must be real ;-) Some of you will probably remember the corresponding insta...



Bottom line: The scientists state it in their conclusion "the number of participants in this pilot study was small", too small for my liking, so that it is - as a standalone - simply not enough to prove anything.

The scientists are yet right that "the present data support the potential for bovine CPC supplementation to maintain testosterone concentrations and influence heart rate variability response" in a training regimen that is notorious for its negative impact on the central nervous system and the HPTA. "Support" and "potential" - not more, but not less either.

References:
  • Shing CM, Peake JM, Suzuki K, Jenkins DG, Coombes JS. A pilot study: bovine
    colostrum supplementation and hormonal and autonomic responses to competitive
    cycling. J Sports Med Phys Fitness. 2013 Oct;53(5):490-501.


Nature gave you a strong immune defense network, but that system gets depleted as you age. Normal physical and mental stress can also wear down your defenses. Colostrum is the only supplement you can take to add back antibodies and action support in the bloodstream and also in the GI tract. It helps maintain a robust intestinal lining and promote healthy intestinal flora. Colostrum Plus supports muscle growth.

Colostrum provides over 100 beneficial components including several growth factors and cytokine precursors that you can't get from any other supplement to enhance stamina and support normal re-growth of lean muscle and tissue. Clinical studies show wide ranging health benefits for Colostrum including a significant increase in lean body mass and increases in anaerobic power, performance time, and sprint performance when compared to whey. Clinical studies also demonstrate the superiority of the ingredient in Symbiotics Colostrum Plus over other Colostrum sources.

Symbiotics guarantees per serving minimums of 1.5% Lactoferrin (14 mg), 25% Immunoglobulins (240 mg IG), and 3% Proline-Rich Polypeptides (29 mg PRP), Colostrum's most important component. Our unique Bio-lipid coating insures bioavailability. Without this protective layer, other Colostrums can be destroyed by stomach acids and offer limited benefit. We use only the first 2 milkings to guarantee potency and quality. Quality and Purity Guaranteed – We guarantee that this product meets the highest standards of quality, purity and freshness. Each bottle is safety sealed with an outer neckband. Do not use if neckband is broken or missing.

Nutrition Facts †

Serving Size 1/3 Scoop
Servings Per Container 620
Amount Per Serving
Serving % DV
Colostrum Plus 960 mg -
*percent Daily Values are based on a 2,000 calorie diet.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
†Nutritions Facts are a simulation of the product "Nutrition Label". For the actual Nutrition Label please refer to the product packaging.

Directions

Mix 1/3 scoop twice daily with water or your drink of choice, on a empty stomach. (3 g scoop included). Triple this amount in times of environmental or physical stress. For children, cut these servings sizes in half. For athletic training and recovery purposes, it is safe to ingest up to 7 scoops (21 g) per day.

Warnings

Suitable for lactose-free diets. Contains milk. Close tightly and store in a dry place at room temperature.

SuppVersity - Nutrition and Exercise Science for Everyone: Ask Dr. Andro: Are Colostrum and Milk Products in ...


SuppVersity - Nutrition and Exercise Science for Everyone: Ask Dr. Andro: Are Colostrum and Milk Products in ...: Image 1: Colostrum and other milk products Milky muscle builders or murky allergens? (image from SportRevue 6/2010) Question from Pet...

Physiological Effect / Classification Compound(s)
Opioid agonists (decrease gastric mobility, increase electrolyte and amino acid uptake) α- ,β-caseins, α-lactalbumin, β-lactoglobulin, serum albumin
ACE inhibitors (increase blood flow to intestinal epithelium) α- ,β-caseins
Mineral binding (increase absorption) α- ,β-caseins
Immunomodulators (increase immune response and phagocytic activity) α- ,β-caseins, gG, IgA, lactoferrin, glycolipids, oligosaccharides, prolactin, cytokines
Antimicrobial αs1 and s2-casein, lactoferrin, oligosaccharides, prolactin
Antithrombotic κ-casein
Probiotic κ-casein, lactoferrin, oligosaccharides
Opioid antagonist κ-casein, lactoferrin
Organ development and function IGF-1, TGF-α, EGF, TGF-β
Increase calcium metabolism and uptake Parathromone - P
Table 1: Milk as a "functional food". Physiological effects and their respective triggers.
(adapted from Schanbacher. 1998; Meisel. 1998 and Clare. 2000)
Author(s) Result(s)
Ferguson-Stegall. 2011b "CM [chocolate milk] postexercise improves aerobic power and body composition more effectively than CHO [carbohydrate] alone"
Ferguson-Stegall. 2011a "CM supplementation can improve subsequent exercise performance and provide a greater intracellular signaling stimulus for PRO synthesis compared to CHO and placebo"
Gilson. 2010 "CM provided similar muscle recovery responses to an isocaloric CHO beverage during four-days of ITD [increased training duration]. Future studies should investigate if the attenuated CK [creatine kinase = marker of muscle damage] levels observed with CM have functional significance during more demanding periods of training"
Pritchett. 2009 "These findings indicate no difference between CHOC and this commercial beverage as potential recovery aids for cyclists between intense workouts."
Thomas. 2009 "Participants cycled 51% and 43% longer after ingesting CM (32 +/- 11 min) than after ingesting [commercially available] CR [carbohydrate drink] (21 +/- 8 min) or FR [fluid replacement drink] (23 +/- 8 min)"
Carp. 2006 "[...] chocolate milk is an effective recovery aid between two exhausting exercise bouts"
Table 2: A selection of recent studies on the ergogenic effects of (chocolate-)milk

Author(s) Result(s)
Shing. 2006 "[10g/day] bovine CPC [colostrum concentrate] supplementation elicited improvements in TT40 [40 km time trial] performance during an HIT period and maintained ventilatory threshold following five consecutive days of HIT"
Buckley. 2003 same increase in peak power for 60g colostrum as with whey protein; no increase in IGF1
Brinkworth. 2004a "[cross sectional area of biceps increased more in trainees supplemented with 60g bovine colostrum than in whey control, but that was] due principally to a greater increase in skin and subcutaneous fat (SSF) CSA"
Buckley. 2003 same increase in peak power for 60g colostrum as with whey protein; no increase in IGF1
Buckley. 2002b "[...] latively few scientifically controlled studies have been conducted. The limited evidence that is currently available suggests that BC supplementation can increase lean body mass and improve exercise performance and recovery for a number of athletic activities, but an understanding of the mechanism by which this supplement exerts these effects remains elusive"
Buckley. 2002a "[...] supplementation with intact powder did not increase plasma IGF-I concentrations or improve performance during an initial bout of incremental running to exhaustion in our sample. However, performance during a second bout of exercise may be improved by as much as 5.2% in the average subject after 8 weeks of supplementation, possibly due to an enhancement of recovery"
Coombes. 2002 "Oral bovine colostrum supplementation at 20 g or 60 g/d provided a small but significant improvement in time trial performance in cyclists after a 2-h ride at 65% VO2max." [improvements were 20g colostrum+40g whey 60g+ colostrum 60g+ whey]
Antonio. 2001 "[...]supplementation with bovine colostrum (20 g/d) in combination with exercise training for 8 wk may increase bone-free lean body mass [+1.5 kg, while whey-placebo group increased overall BM by +2 kg] in active men and women."
Mero. 1997 "appears that a bovine colostrum supplement (Bioenervi) may increase serum IGF-I concentration in athletes during strength and speed training" (cf. discussion in the text)
Table 2: A selection of studies on the ergogenic effects of colostrum





  1. colostrum (skimmed) contains roughly 19x more androgens and 213x more estrogens than whole milk
  2. for milk and colostrum the full fat variety tends to have generally higher levels of both androgens and estrogens - for colostrum, for example the fat fraction contains 10x androgens and 10x more estrogens than the skimmed variety, which is also used as a base for most powdered colostrum supplements
  3. in the case of milk, the ratio of androgens to estrogens (AE-ratio) drops by -34% during the skimming process; in fact, skimmed milk contains more estradiol (per liter) than whole milk.
An Overdue Preliminary Conclusion
Will milk and/or colostrum kill you? No.

Will milk and/or colostrum make you look like Jay Cutler and
unbreakable like Bruce Willis aka David Dunn in the Y2K thriller Unbreakable
within days? Certainly not.

Well, I guess these are the two polar extremes of the preliminary conclusion to this "Ask Dr. Andro" segment and, as it is so often the case, the truth lies somewhere in between. I cannot
tell you your exact position on the death to ultimate health continuum as far as
your personal reaction to dairy consumption is concerned, I can only tell you
that even if your genetic polymorphisms allow you to consume dairy, the
chance that replacing your whey protein by a 6x more expensive colostrum powder
will make a beneficial difference in how you look, feel and perform are
minimal
.

I am not so sure however, if you would not see some, if only psychological (placebo) benefits if you mixed that whey into some real, i.e. whole, liquid and not powdered, 1st day colostrum you bought the very same day from your local farmer ;o)

That being said, I could certainly go on forever on milk, organic milk, milk from happy and milk from pasteur fed cows, the effects of soy on the milk you consume, raw milk, 1st day and 4th day
colostrum, and so on and so forth, but I suppose that Peter, who posed the original question (just in case you forgot due to the informational overkill of this not even half-done write-up), and the rest of you have enough to think about for the coming week. Ah... and in case you can't get enough of milk (I mean metaphorically) just pose another, hopefully more concrete "Ask Dr. Andro"
question
in the comment area or on the SuppVersity's facebook page ;-)


Nature gave you a strong immune defense network, but that system gets depleted as you age. Normal physical and mental stress can also wear down your defenses. Colostrum is the only supplement you can take to add back antibodies and action support in the bloodstream and also in the GI tract. It helps maintain a robust intestinal lining and promote healthy intestinal flora. Colostrum Plus supports muscle growth.

Colostrum provides over 100 beneficial components including several growth factors and cytokine precursors that you can't get from any other supplement to enhance stamina and support normal re-growth of lean muscle and tissue. Clinical studies show wide ranging health benefits for Colostrum including a significant increase in lean body mass and increases in anaerobic power, performance time, and sprint performance when compared to whey. Clinical studies also demonstrate the superiority of the ingredient in Symbiotics Colostrum Plus over other Colostrum sources.

Symbiotics guarantees per serving minimums of 1.5% Lactoferrin (14 mg), 25% Immunoglobulins (240 mg IG), and 3% Proline-Rich Polypeptides (29 mg PRP), Colostrum's most important component. Our unique Bio-lipid coating insures bioavailability. Without this protective layer, other Colostrums can be destroyed by stomach acids and offer limited benefit. We use only the first 2 milkings to guarantee potency and quality. Quality and Purity Guaranteed – We guarantee that this product meets the highest standards of quality, purity and freshness. Each bottle is safety sealed with an outer neckband. Do not use if neckband is broken or missing.

Nutrition Facts †

Serving Size 1/3 Scoop
Servings Per Container 620
Amount Per Serving
Serving % DV
Colostrum Plus 960 mg -
*percent Daily Values are based on a 2,000 calorie diet.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
†Nutritions Facts are a simulation of the product "Nutrition Label". For the actual Nutrition Label please refer to the product packaging.

Directions

Mix 1/3 scoop twice daily with water or your drink of choice, on a empty stomach. (3 g scoop included). Triple this amount in times of environmental or physical stress. For children, cut these servings sizes in half. For athletic training and recovery purposes, it is safe to ingest up to 7 scoops (21 g) per day.

Warnings

Suitable for lactose-free diets. Contains milk. Close tightly and store in a dry place at room temperature.

Tuesday, April 8, 2014

Big Cojones and More Testosterone Courtesy of Apilarnil or Honeybee Drone Milk

I can't make this stuff up. So below are the links and the details. Not sure if you can get it in the U.S. but it seems to be available in Europe.

Ergo-Log: Drone milk: boosts testosterone and has an anabolic effect too

Exerpt: Drone milk is not the same as Royal Jelly. Honeybees make Royal Jelly as a special nutrient for the queen bees, but give drone milk to worker bees, or drones. Drones are male and one of their tasks is to provide the sperm to fertilize the queen's eggs.



Traditional healers in Eastern Europe have been giving drone milk to older men as an anti-aging remedy or aphrodisiac for centuries. It's even possible that drone milk actually works, researchers at the University of Szeged in Hungary write in the Journal of Ethnopharmacology. According to their animal studies, drone milk has anabolic and androgenic properties.






Drone Milk is available as a supplement on the market. The Russian company Apidom produces Frozen Drone Larvae Royal Jelly; the Romanian Biofarm manufactures Apilranil Potent. The Hungarians used fresh drone milk for their experiments, which they had obtained from a professional beekeeper.



The researchers gave castrated rats 11, 110 or 1100 mg drone milk per kg bodyweight for 10 days, and discovered that the 110 mg dose had androgenic and anabolic effects. The human equivalent of this dose would be 17.8 mg per kg bodyweight. So if you weigh 80 kg, you'd need about 1420 mg fresh drone milk daily.



Drone milk [DM] caused the rats' penis to grow and increased the weight of their levator ani muscle, both indications of anabolic and androgenic effects. Synthetic testosterone [T] worked better than drone milk, and the anti-androgen flutamide [F] negated the effects of drone milk.




Traditional healers in Eastern Europe have been giving drone milk to older men as an anti-aging remedy or aphrodisiac for centuries. It's even possible that drone milk actually works, researchers at the University of Szeged in Hungary write in the Journal of Ethnopharmacology. According to their animal studies, drone milk has anabolic and androgenic properties.


Drone milk had an indirect effect. It boosted the concentration of testosterone.

Studies:

The Effects of Apilarnil (Drone Bee Larvae) Administration ...

by B Yucel - ‎2011 - ‎Cited by 2 - ‎Related articles
Abstract: This study examined the anabolic and androgenic effects of apilarnil, a bee product on broilers. The study included 40 Ross-308 genotype broilers ...

Apilarnil reduces fear and advances sexual development in ...


www.ncbi.nlm.nih.gov/...
National Center for Biotechnology Information
by O Altan - ‎2013 - ‎Related articles
Br Poult Sci. 2013 Jun;54(3):355-61. doi: 10.1080/00071668.2013.791382. Apilarnil reduces fear and advances sexual development in male broilers but has no ...
Increases in testicular weight, testosterone concentration and comb growth in males receiving apilarnil implied that it stimulates the sexual maturation at an early age. However, a similar stimulation of secondary sexual characteristics was not observed in females.