Stack Ashwaghanda and GABA for Better Sleep

How to Take GABA

Supplemental GABA has been used in humans (for the purpose of enhancing growth hormone metabolism) in the dosage range of 3,000-5,000mg GABA. It is unsure if this is the optimal dosage. 

Source:
https://examine.com/supplements/gaba/

How to Take Ashwagandha

Take 300–500 mg of a root extract with meals (with breakfast, if taken all at once). More research is needed to determine if higher doses can yield greater benefits. Lower doses (50–100 mg) have been shown to help in some instances, such as reducing stress-induced immunosuppression and enhancing the effect of other anxiolytic agents.

Source:
https://examine.com/supplements/ashwagandha/

More Information:

Ashwagandha Supplement - Science-based Review on Benefits ...

https://examine.com/supplements/ashwagandha/

Jul 29, 2019 - Ashwagandha appears to be involved in signalling through the GABAA receptor, as its beneficial influences on sleep are abolished with ...

Ashwagandha

Ashwagandha accelerates increase of muscle strength in novice strength athletes 25.12.2018
Withaferin-A counteracts obesity by increasing leptin sensitivity 30.09.2018
Ashwagandha improves sex for women 21.04.2016
Daily 600 mg ashwagandha helps resistance trainers build more muscle and lose more fat 11.01.2016
Human study: ashwagandha boosts testosterone level 19.06.2014
Ashwagandha: more muscle strength, more lean body mass & lower fat percentage 19.12.2013
Test-tube study: ashwagandha inhibits Alzheimer's 10.08.2011
Speed up your sprints with ashwagandha 19.04.2011
Forty percent more testosterone with ashwagandha 19.07.2009

GABA

How arginine enhances the effect of GABA 18.06.2019
Humulus lupulus interacts with GABA receptor, combats depression, anxiety, and stress 02.09.2018
GABA-booster Melissa officinalis is a supplement for worriers 18.06.2016
Non-alcoholic beer improves sleep quality by boosting the functioning of the GABA receptor 28.11.2015
Caffeine making you sleep badly? GABA helps 22.09.2015
13-OXO-ODA, esculeoside-A and GABA in tomato juice reduce menopause symptoms 05.08.2015
Animal study: acerola (contains GABA) inhibits growth of fat tissue20.03.2015
GABA: body fat inhibitor and insulin booster 30.12.2014
GABA quadruples post-training GH production 09.06.2010

Ashwagandha enhances GABA receptors and serotonin in the brain. It appears to work on neuron receptors, enabling GABA to connect easier. This inhibits the signals present under a stress response in the brain. Anxiety goes down.Mar 26, 2016

Ashwagandha – Nootropics Expert

https://nootropicsexpert.com/ashwagandha/

In a study to determine a safe and effective dosage for ashwagandha, healthy men who took 750–1,250 mg per day of pulverized ashwagandha root per day gained muscle strength after 30 days ( 4 ).Jun 11, 2018

12 Proven Health Benefits of Ashwagandha - Healthline

https://www.healthline.com/nutrition/12-proven-ashwagandha-benefits

The medicinal herb appears to help lower levels of cortisol, a hormone produced by your adrenal glands in response to stress. ... Summary Ashwagandha seems effective at lowering symptoms of stress and anxiety. Most benefits are linked to dosages of 500–600 mg per day taken for at least one month.Sep 1, 2018

Ashwagandha Dosage: How Much Should You Take per Day?

https://www.healthline.com/nutrition/ashwagandha-dosage

Direct evidence for GABAergic activity of Withania somnifera on ... - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/26068424

by M Candelario - ‎2015 - ‎Cited by 25 - ‎Related articles

Jun 9, 2015 - Our results show that aqWS activated inotropic GABAA channels but with lower efficacy compared to the endogenous agonist GABA. We also ...

Get Better Sleep With GABA, Ashwagandha, and Melatonin — Tiger ...

https://www.tigerfitness.com/blogs/.../get-better-sleep-gaba-ashwagandha-and-melaton...

Oct 8, 2017 - The breakthrough formula includes GABA, ashwagandha, and melatonin. This trifecta of ingredients works together to enhance your quality of ...

Universal Nutrition Animal PM The Nighttime Anabolic Recovery Stack Supplement

Study Links: MK-677, an orally active growth hormone secretagogue

J Clin Endocrinol Metab. 1996 Dec;81(12):4249-57.

Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.

Chapman IM¹, Bach MA, Van Cauter E, Farmer M, Krupa D, Taylor AM, Schilling LM, Cole KY, Skiles EH, Pezzoli SS, Hartman ML, Veldhuis JD, Gormley GJ, Thorner MO.

https://www.ncbi.nlm.nih.gov/pubmed/8954023


MK-677 produced significant increases in fasting glucose (5.4 +/- 0.3 to 6.8 +/- 0.4 mmol/L at 4 weeks; P < 0.01 vs. baseline) and IGF-binding protein-3. Circulating cortisol concentrations did not change, and PRL concentrations increased 23%, but remained within the normal range. Once daily treatment of older people with oral MK-677 for up to 4 weeks enhanced pulsatile GH release, significantly increased serum GH and IGF-I concentrations, and, at a dose of 25 mg/day, restored serum IGF-I concentrations to those of young adults.


=================================================================


J Clin Endocrinol Metab. 1998 Feb;83(2):320-5.

MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism.

Murphy MG¹, Plunkett LM, Gertz BJ, He W, Wittreich J, Polvino WM, Clemmons DR.

https://www.ncbi.nlm.nih.gov/pubmed/9467534

=================================================================

J Clin Endocrinol Metab. 1998 Feb;83(2):362-9.

Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure.

Svensson J¹, Lönn L, Jansson JO, Murphy G, Wyss D, Krupa D, Cerchio K, Polvino W, Gertz B, Boseaus I, Sjöström L, Bengtsson BA.

https://www.ncbi.nlm.nih.gov/pubmed/9467542

=================================================================

J Clin Endocrinol Metab. 1997 Oct;82(10):3455-63.

Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults.

Chapman IM¹, Pescovitz OH, Murphy G, Treep T, Cerchio KA, Krupa D, Gertz B, Polvino WJ, Skiles EH, Pezzoli SS, Thorner MO.

https://www.ncbi.nlm.nih.gov/pubmed/9329386

Pharmafreak Stack for Natural Testosterone and Growth Hormone Support

(1)PharmaFreak Test Freak Testosterone Booster (1) PharmaFreak Anabolic Freak Testosterone Booster and (1) GH Freak - Sleep Supplement | BODYBUILDING SUPPLEMENT STACK | D-Aspartic Acid, Fenugreek,Tribulus, 5-HTP, Stinging Nettle

About the product:

• PHARMAFREAK TEST FREAK TESTOSTERONE BOOSTER is designed to be the best testosterone booster available! Contains natural ingredients like Fenugreek, Tribulus, Saw Palmetto and Stinging Nettle proven to help BOOST TESTOSTERONE PRODUCTION.
• TEST FREAK Includes Hesperidin, Apigenin and Resveratrol to help LOWER ESTROGEN LEVELS. Contains 2 anti-DHT compounds and 3 anti-Aromatase compounds.
• PHARMAFREAK ANABOLIC FREAK TESTOSTERONE BOOSTER works by MINIMIZING the production of CORTISOL and ESTROGEN. Includes d-aspartic acid (DAA) calcium chelate, vitamins D, B6, B12 and folate.
• Includes a DOUBLE DOSE of two of the BEST TESTOSTERONE BOOSTER on the market, along with a proven SLEEP and RECOVERY supplement. This combination makes it a POWERFUL BODYBUILDING STACK, giving you a real bang for your buck!
• You get 1 TEST FREAK testosterone booster + 1 ANABOLIC FREAK testosterone booster + 1 GH FREAK sleep and recovery supplement. Not only will it help you get results in the gym, but it is known to BOOST YOUR LIBIDO as well.

Increase Penis Size and Quality of Erections

Mucuna Pruriens 40% L-dopa Extract - 60 650mg VegiCaps -Stearate Free, Bottled in Glass! FREE SHIPPING on orders over $49!

Penile girth (maximum girth and nightly tumescence) were significantly increased after 800mg L-DOPA for 7 days via https://examine.com/supplements/l-dopa/#hem-penile-girth

Mucuna Pruriens or Velvet Bean, is a plant that has high concentrations of levodopa (L-Dopa). The amino acid that is the precursor to the neurotransmitter dopamine.  L-Dopa has been shown to inhibit prolactin acting on the pituitary gland.

In addition to the reduction of prolactin, Mucuna Pruriens is an libido booster by increasing the release of luteinizing hormone (LH) which inturn supports the production of testosterone.

Mucuna Pruriens also has supportive serotonin and opioid receptor ligands. This ligands combined with L-Dopa support mood improvements. Low dopamine and mood have also been related to mood related over eating.

As a side note for bodybuilders, prolactin inhibition has been shown to help prevent the dreaded formation of gynecomastia.

Try 100-400mg taken 30-60 minutes before workouts and before bedtime with an upper limit of 1 gram per day. Besure to cycle not taking more that 6 - 8 weeks with 4 weeks off.


Supporting Research:
Antifungal Activity of Mucuna pruriens Seed Extractives and L-dopa.

Ganeshan, Girija; Lokesha, A. N.; Nidiry, Eugene Sebastian J.

Journal of Herbs, Spices & Medicinal Plants (1049-6475)

20110401. Vol.17,Iss.2;p.139-143

Mucuna pruriens: more testosterone, more LH, less prolactin

Plant-based growth hormone booster: sometimes it works and ...

Size Does Matter! Mucuna Counters Estrogenic Assaults & Doubles Testosterone. High Hair Cortisol, CVD & Diabetes. Catabolic Laziness. Health & Obesity = Incompatible

"Diets alter dopamine receptors." Flex May 2013: 128. Academic OneFile. Web. 13 Aug. 2013

"Junk-food addiction." Joe Weider's Muscle & Fitness Jan. 2011: 39.

Mucuna Pruriens From Wikipedia, the free encyclopedia

Testosterone Therapy - Royal Men's Medical Center
Great Service and Price - Tell them Michael Henry referred you. https://t.co/0HQkC961lN pic.twitter.com/jFdMxBzhmj

— #HelpYouGetGAINS (@helpYOUgetGAINS) October 14, 2017

Piping Rock GHR Complex (Growth Hormone Releaser) Compare to SeroVital-HGH

• Provides a healthy release of growth hormone**
• Supplies vitamins that encourage overall health & vitality**
• Sourced from all-natural ingredients

#helpYOUgetGAINS 
Twitter: @helpYOUgetGAINS

Get GHR at Piping Rock Supplements!

Testosterone Therapy - Royal Men's Medical Center
Great Service and Price - Tell them Michael Henry referred you. https://t.co/0HQkC961lN pic.twitter.com/pLPd4uTAOt

— #HelpYouGetGAINS (@helpYOUgetGAINS) September 26, 2017

SeroVital-HGH: Anti-Aging, Fat Loss and Growth Hormone Support Supplement

#helpYOUgetGAINS 
Twitter: @helpYOUgetGAINS

That's a serious claim. Only time will tell if it pans out. I took a look at the ingredients and it appears that they are amino acids that have been shown previously to increase growth hormone levels.

SeroVital™-hgh 2.9 g A, Proprietary Blend Containing: L-Lysine HCl, L-Arginine HCl, Oxo-Proline, N-Acetyl, L-Cysteine, L-Glutamine, Schizonepeta (aerial parts) powder

As with all of these supplements, I would say give it a shot and see how you react to it. I would not expect short-term results. You would have to be very consistent in diet, stress reduction, sleep and exercise to support a product like this.

I have pasted the study abstract below for your review. The presented at the Obesity Society’s prestigious 30th Annual Scientific Meeting.

Elevated Growth Hormone 120 Minutes Following a Single Low-Dose of Amino Acids in Healthy Subjects

Abstract:

Background
The use of amino acid supplements to provoke growth hormone (GH) secretion in athletes and entertainers now extends to the general public. Not only do they have a goal of building lean tissue and reducing fat, but also in improving skin quality and other rejuvenating qualities that they believe GH can provide. Despite increasing mainstream use, evidence for whether oral amino acids stimulate GH is not clear.

Methods:
This was a cross-over, placebo-controlled randomized study. 16 (12 males; 32±14 years; 26.4±5.0 kg/m2) healthy subjects had serum GH measured at baseline and 15, 30, 60, 90 and 120 minutes after taking a single low dose proprietary amino acid supplement blend (SeroVital™) or placebo.

Results:
After 120 minutes, GH levels had increased 8-fold from baseline (0.17 to 1.33ng/ml) and were significantly higher than placebo (P=0.01). In addition, a significantly higher mean AUC was observed after taking the supplement [20.4 (95% CI: 19.9-21.0ng/ml) vs. 19.7 (95% CI: 18.7-20.6ng/ml); P=0.04].

Conclusions: Our results show that a single oral dose of these amino acids can significantly increase GH Levels after 120 minutes in healthy men and women. Whether these GH changes persist over a longer duration or have other positive effects is being further examined.

Fat Shredding Big HGH Stack

Glycine 1,000 to 5,000 mg

Taurine 1,000 to 3,000 mg

Between meals or at bedtime.

Always start low and increase dosage slowly.

 

Supporting Research:
The anticatabolic effect of glycine 23.06.2014
The best high-protein slimming diet contains lots of taurine and glycine 13.04.2014
Glycine boosts reaction time with lack of sleep 19.02.2013
Glycine boosts reaction time with lack of sleep 18.02.2013
Three grams glycine improves your sleep 17.02.2013
Glycine Propionyl-L-Carnitine as an NO booster 03.10.2010

Taurine boosts glucose uptake in muscles 30.12.2013
Taurine makes muscles stronger 08.11.2013
Taurine for more testosterone 03.11.2013
During strength training BCAA's protect the muscles better when combined with taurine 03.11.2013
Take up to twelve seconds off your time for a 3K run with 1 g taurine 10.09.2012
Give endurance athletes 5 g taurine every day for a week… 06.02.2011
Taurine doubles testosterone level: animal study 30.07.2010
Animal study: taurine improves endurance 25.11.2008

SuppVersity - Nutrition and Exercise Science for Everyone: Anabolic Workouts Revisited - Testosterone, GH, Pr...

SuppVersity - Nutrition and Exercise Science for Everyone: Anabolic Workouts Revisited - Testosterone, GH, Pr...: Ronnie Coleman is just one of the pros who trained with crazily high volume and weights - is that the way to go, or does it require too m...

Mucuna Pruriens - Testosterone, Mood, Growth Hormone, Lower Prolactin and Beat a Junk-Food Craving

Mucuna Pruriens or Velvet Bean, is a plant that has high concentrations of levodopa (L-Dopa). The amino acid that is the precursor to the neurotransmitter dopamine.  L-Dopa has been shown to inhibit prolactin acting on the pituitary gland.

In addition to the reduction of prolactin, Mucuna Pruriens is an libido booster by increasing the release of luteinizing hormone (LH) which inturn supports the production of testosterone.

Mucuna Pruriens also has supportive serotonin and opioid receptor ligands. This ligands combined with L-Dopa support mood improvements. Low dopamine and mood have also been related to mood related over eating.

As a side note for bodybuilders, prolactin inhibition has been shown to help prevent the dreaded formation of gynecomastia.



Try 100-400mg taken 30-60 minutes before workouts and before bedtime with an upper limit of 1 gram per day. Besure to cycle not taking more that 6 - 8 weeks with 4 weeks off.


Supporting Research:
Antifungal Activity of Mucuna pruriens Seed Extractives and L-dopa.

Ganeshan, Girija; Lokesha, A. N.; Nidiry, Eugene Sebastian J.

Journal of Herbs, Spices & Medicinal Plants (1049-6475)

20110401. Vol.17,Iss.2;p.139-143

Mucuna pruriens: more testosterone, more LH, less prolactin

Plant-based growth hormone booster: sometimes it works and ...

Size Does Matter! Mucuna Counters Estrogenic Assaults & Doubles Testosterone. High Hair Cortisol, CVD & Diabetes. Catabolic Laziness. Health & Obesity = Incompatible

"Diets alter dopamine receptors." Flex May 2013: 128. Academic OneFile. Web. 13 Aug. 2013

"Junk-food addiction." Joe Weider's Muscle & Fitness Jan. 2011: 39.

Mucuna Pruriens From Wikipedia, the free encyclopedia

FoodScience of Vermont Maxi-HGH 10.83 oz for support of optimal growth hormone levels

Click the photo to purchase.

FoodScience of Vermont Maxi-HGH Description:

• Where Science and Nature Come Together
• A Dietary Supplement to Support Cardiovascular and Growth Hormone Functions and Fat Metabolism
• Vegetarian

We pledge total truth in labeling. Our family of products contain only the purest and most potent ingredients. Guaranteed.

Maxi-HGH is a free-form amino acid supplement containing only the highest quality amino acids.

Maxi-HGH Supports:

• Growth Hormone Levels within Normal Ranges
• Improvement in Workout Recovery
• Cardiovascular Health
• Reduction in Sugar Cravings
• Reduction in Body Fat

Maxi-HGH represents a safe, cost-effective approach to supporting both the storage and release of the body's own human growth hormone.
Disclaimer These statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.
• FoodScience of Vermont Maxi-HGH Directions
As a dietary supplement, mix 1 scoop (10.25 g) per day in 8 oz. juice or water and take on an empty stomach at bedtime or right after a strenuous exercise.

Supplement Facts
Serving Size: 1 Scoop (10.25 g)
Servings Per Container: 30

	Amt Per Serving	% Daily Value
L-Glutamine	6000 mg	*
L-Arginine	1000 mg	*
L-Ornithine	1000 mg	*
L-Lysine	1250 mg	*
Glycine	1000 mg	*

*Daily value not established. Other Ingredients: None. Warnings
Persons with kidney disorders should consult with their health care practitioner prior to using this product. If you are pregnant or nursing, consult your health care practitioner before taking this product.

Color of this product may vary due to color variations of the natural ingredients. Store in a cool, dry place at 59-86 degrees. Keep out of reach of children.

Other Posts:
The below information was exerpted from Growth Hormone: Amino Acids as GH Secretagogues – A Review of the Literature.

Amino Acids	Study Results
Intravenous Ornithine	Produces a five-fold increase in serum growth hormone in humans.
Ornithine	Increased serum growth hormone in bodybuilders, up to four times the baseline level.
Arginine	250 mg/kg/day of oral arginine aspartate given to five healthy subjects for seven days caused a 60% rise in GH during slow wave sleep compared to the control period.
Arginine and Ornithine	In a double-blind study, adult males participating in a 5-week progressive strength-training program who consumed 2 grams of L-arginine and 1 gram of L-ornithine experienced significantly higher total strength and lean body mass scores and excreted less urinary hydroxyproline than placebo-treated subjects.
Ornithine Alpha-ketoglutarate (OKG)	Significantly increased IGF-1 and growth hormone levels in trauma patients. In healthy subject, OKG increased tissue levels of growth-hormone-releasing glutamine.
Arginine and lysine	1200 milligrams of arginine pyroglutamate combined with L-lysine hydrochloride significantly elevated biologically active growth hormone from two to eight times the baseline value in 15 healthy male subjects aged 15 to 20 years old.
Arginine and lysine	1,500 mg arginine and 1,500 mg lysine increased GH in young men only during resting conditions.
Glycine	In 19 normal, non-obese subjects, 6.75 grams of glycine increased growth hormone levels up to 300 to 400 percent that of baseline.
Glycine and L-arginine	Increased the subjects mean resistance to fatigue up to 28% over the controls during acute exhaustive high-intensity anaerobic isokinetic exercise and produced an overall gain in total muscle work of 10.5% more than controls.
Gamma Aminobutyric Acid (GABA)	A single oral dose of 5 grams of GABA administered to 19 subjects significantly elevated plasma growth hormone levels compared to placebo-treated controls.
Glutamine	Two grams of oral glutamine resulted in elevated plasma growth hormone in 8 of 9 subjects tested.