Wednesday, June 21, 2017

Nutrient Partitioning with Indigo-3G® Cyanidin 3-glucoside (C3G)

Product description from the manufacturer.

·         Controls carbs to build muscle.
·         Maximizes nutrient uptake in muscle.
·         Releases and burns body fat.
·         Prevents the storage of fat.

Scientists have discovered a naturally occurring compound — called cyanidin 3-glucoside (C3G) — that has the ability to precisely control carbohydrates so that what you eat literally turns to muscle instead of fat. 

This might seem hard to believe, but research has proven C3G's effects on insulin signaling, selective insulin sensitivity, glucose and nutrient management, as well as its direct effect on fat and muscle cells, is extremely elaborate and precise. 
C3G literally makes your body function perfectly for building muscle mass without the fear of gaining fat, even while on a bulking diet, making the body-building process a whole new ballgame. No more depriving yourself of the optimal nutrition for building muscle because "your body can't handle the carbs" — because now it can. 
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Matsukawa, et al, The Type II Diabetes-preventive Effect of Cyanidin-3-glucoside on Adipocytes, Journal of Development in Sustainable Agriculture, 11: 31-35, 2016

Cyanidin-3-O-β-glucoside regulates fatty acid metabolism via an AMP-activated protein kinase-dependent signaling pathway in human HepG2 cells.
Lipids Health Dis. 2012 Jan 13;11:10. doi: 10.1186/1476-511X-11-10. Guo H1, Liu G, Zhong R, Wang Y, Wang D, Xia M.

Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity.
J Sci Food Agric. 2011 Apr;91(6):1006-13. doi: 10.1002/jsfa.4275. Epub 2011 Feb 24. Wei X1, Wang D, Yang Y, Xia M, Li D, Li G, Zhu Y, Xiao Y, Ling W.

Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1.
J Nutr Biochem. 2012 Apr;23(4):349-60. doi: 10.1016/j.jnutbio.2010.12.013. Epub 2011 May 2. Guo H1, Xia M, Zou T, Ling W, Zhong R, Zhang W.

Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice.
Biochem Pharmacol. 2007 Dec 3;74(11):1619-27. Epub 2007 Aug 10.

Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice.
J Nutr. 2003 Jul;133(7):2125-30.

Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation.
Biochem Pharmacol. 2008 Mar 15;75(6):1393-401. Epub 2007 Dec 3.

Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton.
Phytomedicine. 2009 May;16(5):406-15. Epub 2009 Mar 20.

Gene expression profile of isolated rat adipocytes treated with anthocyanins.
Biochim Biophys Acta. 2005 Apr 15;1733(2-3):137-47. Epub 2005 Jan 12.

Microarray profiling of gene expression in human adipocytes in response to anthocyanins.
Biochem Pharmacol. 2006 Apr 14;71(8):1184-97. Epub 2006 Feb 17.

Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes.
Biochem Biophys Res Commun. 2004 Mar 26;316(1):149-57.