Thursday, July 26, 2018

Excerpt from The effects of Testosterone by John Connor 300 mg vs 600 mg

If a first time user wanted to use 600 mg of cypionate or enanthate per week he would inject 300 mg on Tuesday and another 300 mg on Saturday each week for 10 weeks.
12 men participated in the 300 mg group and 13 men in the 600 mg group.
600mg of Testosterone a week for 20 weeks resulted in the following benefits. Increased fat free mass, muscle strength, muscle power, muscle volume, hemoglobin and IGF-1.
The same 600 mg administration resulted in 2 side effects. HDL cholesterol was negatively correlated and 2 men developed acne.
The normal range for total T in men is 241-827 ng/dl according to Labcorp and 260-1000 ng/dl according to Quest Laboratories. The normal range for IGF-1 is 81-225 according to Labcorp. Total T and IGF-1 levels were taken after 16 weeks and resulted in the following;
Total Testosterone
300 mg group-1,345 ng/dl a 691 ng increase from baseline
600 mg group-2,370 ng/dl a 1,737 ng increase from baseline

IGF-1
300 mg group-388 ng/dl a 74 ng increase from baseline
600 mg group-304 ng/dl a 77 ng increase from baseline
Body composition was measured after 20 weeks.
Fat Free Mass by underwater weighing
300 mg group-5.2kg (11.4lbs) increase
600 mg group-7.9kg (17.38lbs) increase

Fat Mass by underwater weighing
300 mg group-.5kg (1.1lbs) decrease
600 mg group-1.1kg (2.42lbs) decrease

Thigh Muscle Volume
300 mg group-84 cubic centimeter increase
600 mg group-126 cubic centimeter increase

Quadriceps Muscle Volume
300 mg group-43 cubic centimeter increase
600 mg group-68 cubic centimeter increase

Leg Press Strength
300 mg group-72.2kg (158.8lbs) increase
600 mg group-76.5kg (168.3lbs) increase

Leg Power
300 mg group-38.6 watt increase
600 mg group-48.1 watt increase

Hemoglobin
300 mg group-6.1 gram per liter increase
600 mg group-14.2 gram per liter increase

Plasma HDL Cholesterol
300 mg group-5.7 mg/dl decrease
600 mg group-8.4 mg/dl decrease

Acne
300 mg group-7 of the 12 men developed acne
600 mg group-2 of the 13 men developed acne
There were no significant changes in PSA or liver enzymes at any dose up to 600mg. However, long-term effects of androgen administration on the prostate, cardiovascular risk, and behavior are unknown. The study demonstrated that there is a dose dependent relationship with testosterone administration. In other words the more testosterone administered the greater the muscle building effects and potential for side effects.
Pharmacokinetics of Testosterone cypionate Injection

 Source: Schulte-Beerbuhl, 1980 Figure. Pharmacokinetics of 200mg Testosterone cypionate injection. Source: Comparison of Testosterone, dihydrotestosterone, luteinizing hormone, and follicle-stimulating hormone in serum after injection of Testosterone enanthate or Testosterone cypionate. Schulte-Beerbuhl M, Nieschlag E. Fertility and Sterility 33 (1980) 201-3.

Sample cycle with ancillaries

Sunday 10mg Aromasin
Monday 10mg Aromasin/500iu HCG
Tuesday 10mg Aromasin/300mg Enanthate
Wednesday 10mg Aromasin
Thursday 10mg Aromasin
Friday 10mg Aromasin/500iu HCG
Saturday 10mg Aromasin/300mg Enanthate

I recommend the following PCT protocol for esters like Cypionate and Enanthate;
While the aas ester is clearing : 2500iu HCG every third day for 2 weeks. (You may use less HCG if your testes are normal in size AND you have been using HCG on cycle, i.e. 1,000iu HCG every third day.)
100/100/100/50 Clomid (50mg taken twice per day weeks 1-3 AFTER the aas ester clears)
20mg/20mg/20mg Aromasin (20mg daily for 3 weeks)
3g Vit C every day split in 3 doses
10g creatine daily


References:
1.Testosterone dose-response relationships in healthy young men;
2.Pharmacokinetics and Dose Finding of a Potent Aromatase Inhibitor, Aromasin (Exemestane), in Young Males
3.Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression
4.Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse.
5.Changes in the Endocrinological Milieu After Clomiphene Citrate Treatment for Oligozoospermia: The Clinical Significance of the Estradiol/Testosterone Ratio as a Prognostic Value
6.Testicular steroidogenesis after human chorionic gonadotropin desensitization in rats.
7.Effect of tamoxifen on GH and IGF-1 serum level in stage I-II breast cancer patients
8.Treatment of gynecomastia with tamoxifen: A double-blind crossover study
9.Role of testosterone/estradiol ratio in predicting the efficacy of tamoxifen citrate treatment in idiopathic oligoasthenoteratozoospermic men.

http://www.ironmagazine.com/2012/the-effects-of-testosterone-on-the-body/

Abstract

Testosterone dose-response relationships in healthy young men. - NCBI

https://www.ncbi.nlm.nih.gov/pubmed/11701431
by S Bhasin - ‎2001 - ‎Cited by 750 - ‎Related articles
Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81. Testosterone dose-response relationships in healthy young men. Bhasin S(1), Woodhouse L, ...

Full Text

Testosterone dose-response relationships in healthy young men ...

ajpendo.physiology.org/content/281/6/E1172
1.      
by S Bhasin - ‎2001 - ‎Cited by 755 - ‎Related articles

Dec 1, 2001 - Testosterone dose-response relationships in healthy young men. Shalender Bhasin, Linda Woodhouse, Richard Casaburi, Atam B. Singh, ...








Additional Resources:

The impact of an aromatase inhibitor on body composition and ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103776/




Clomiphene increases free testosterone levels in men with ... - Nature

https://www.nature.com › international journal of impotence research › original research
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Testosterone Cypionate - FDA prescribing information, side effects ...

The half-life of Testosterone Cypionate when injected intramuscularly is approximately eight days. In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins.Sep 1, 2018

https://www.drugs.com/pro/testosterone-cypionate.html





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