Showing posts with label Brown Fat. Show all posts
Showing posts with label Brown Fat. Show all posts

Saturday, December 8, 2018

BAIBA | β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation

From the manufacturer:
Serving Size 2 capsules
500mg Beta-aminoisobutyric acid per Capsule
Beta-aminoisobutyric acid, or BAIBA for short.
When you exercise, benefits of that exercise are seen in many different organs of the body, not just the muscles that were exercised. These metabolic benefits are the result of “messenger” molecules that are released into the blood stream and travel to other tissues where the benefits of exercise are realised. One such messenger molecule, or “myokine”, is understood to be the amino acid beta-aminoisobutyric acid.
BAIBA is an amino acid that your body produces in response to exercise. After being released into the blood stream, it starts a thermogenic program in fat tissue, raising energy expenditure and reducing weight gain when tested in mice. When mouse or human white fat cells are exposed to BAIBA, some of them become fat-burning “beige” fat cells. Beige (or BRITE) fat cells contain the protein UCP-1 – also known as “thermogenin” because it burns triglycerides to produce heat.
– BAIBA is produced naturally by the human body – it’s formed from the catabolism of thymine [1][2] and is also product of exercise-induced PGC1a-mediated amino acid breakdown. [3]
– BAIBA increases the utilization of free fatty acids and decreases fat mass in mice. [4]
– BAIBA stimulates the differentiation of white fat cells into thermogenic beige/brite fat cells in both in vivo animal experiments and in vitro human stem cell studies. [5][6]
LGI βAIBA contains just the amino acid BAIBA. It is suitable for both men and women.
Studies suggest BAIBA may:
– Increase lipolysis and the beta-oxidation of fatty acids (“fat burning”)
– Increase body temperature and energy expenditure
– Increase ketogenesis (the production of ketone bodies in the liver)
βAIBA is suited for use by:
– those trying to lose weight, in combination with a healthy diet and exercise regime
– those trying to reap the maximal metabolic benefits from their exercise regime
– those who may be temporarily unable to exercise through injury or illness
1. β-Aminoisobutyric Acid, a New Probe for the Metabolism of DNA and RNA in Normal and Tumorous Tissue. Cancer Res 34, 1381–1384.
2. The excretion of beta-aminoisobutyric acid following thymine and dihydrothymine administration to man. Aust J Exp Biol Med Sci 39, 423–427.
3. PGC-1α-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle. PLoS ONE 9, e91006.
4. Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting. Antivir. Ther. (Lond.) 9, 801–810.
5. β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors. Cell Metabolism 19, 96–108.
6. Come on BAIBA Light My Fire. Cell Metabolism 19, 1–2.


BAIBA: New Ingredient Generates Exercise in a Pill?!

https://blog.priceplow.com/baiba

May 19, 2015 - BAIBA, or 3-Aminoisobutyric Acid, was discovered as an "exercise molecule", since we produce it when we work out. Can supplementing ...

3-Aminoisobutyric acid - Wikipedia


https://en.wikipedia.org/wiki/3-Aminoisobutyric_acid

Aminoisobutyric acid is a product formed by the catabolism of thymine. During exercise, the increase of PGC-1α protein triggers the secretion of BAIBA from ...


Nov 1, 2015 - Beta-aminoisobutyric acid, aka BAIBA, is a natural catabolite of thymine. As with many other purported "next big things in fat loss supplements", ...

Wednesday, November 21, 2018

Melatonin Supplementation Lowers Oxidative Stress and Regulates Adipokines in Obese Patients on a Calorie-Restricted Diet






Dosage: 10 mg per day

Melatonin Supplementation Lowers Oxidative Stress and Regulates ...



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632922/
by K Szewczyk-Golec - ‎2017 - ‎Cited by 2 - ‎Related articles
Sep 21, 2017 - Thirty obese patients were supplemented with a daily dose of 10 mg ... The results show evidence of increased oxidative stress ... Moreover, melatonin may increase the energy expenditure by activating brown adipose tissue ...








May 10, 2018 - Firstly, melatonin increased the brown adipose tissue (BAT) mass of the treated animals (the amount of "good fat" that uses up energy rather ...


Oct 8, 2018 - The new discovery that a substantial amount of functional brown adipose... ... of melatonin in the regulation of brown adipose tissue metabolism: Relation .... which expresses high levels of MT 2 and displays profound synaptic ...


Jan 17, 2014 - Brown fat is a heat-generating type of fat that burns energy instead of storing it, ... Women also tend to have more brown fat than men, and people taking beta ... Consuming melatonin stimulates the appearance of "beige" fat, ...


Melatonin Aids Formation of "Brown Fat" Which Promotes Weight Loss ... Melatonin treated rats were found to produce a higher heat signature in the inguinal ...
Missing: dose ‎| ‎Must include: ‎dose


by MJ Rudolph - ‎Related articles
Dec 18, 2017 - However, higher levels of ATP do not reduce body fat. .... that long-term intake of capsaicin can also increase the amount of brown fat in the body. ... Melatonin is also involved in energy metabolism and bodyweight control.


by S Blechman
Aug 30, 2018 - It's also involved in energy metabolism/weight loss related to brown fat. ... that melatonin increased brown adipose tissue (BAT) in treated animals. ... we demonstrated that small doses of melatonin (1 and 3 mg/d) have ...


Jul 31, 2015 - Melatonin for Weight Loss, brown fat, fat cells ... up most fat on an adult human body, brown fat actually burns calories at a high rate. ... their health care provider before taking any supplement with the intention of losing weight.

Tuesday, October 24, 2017

An Experiment in Spot Fat Reduction



Step One - Heat the area of concern with a heating pad. Or use a waist trimmer belt.
Step Two - Do 3 rounds of Tabata exercise with a focus on the trouble area. This will take about 12 minutes.

Step Three -  Do 45 to 60 minutes of steady state cardio to burn of the fat released in steps 1 and 2.


This should all be done in a fasted state. Add 2.5 mg of Yohimbine HCL into the mix.

Give it a try and let me know what your results are.

Further Reading:

Spot Reduction is Real | T Nation

https://www.t-nation.com/diet-fat-loss/spot-reduction-is-real

Feb 1, 2011 - Non-surgical spot reduction is a myth – a fat housewife's fantasy; the fodder of ... All of these legendary bodybuilders believed they could spot-reduce, and they did .... Step 2: Work the muscles adjacent to the trouble spot.


Six New Tabata Workouts for Fast Fat Loss | T Nation

https://www.t-nation.com/training/6-new-tabata-workouts-for-fast-fat-loss

Feb 4, 2010 - If you don't already know what a Tabata interval is, it's a high intensity interval training protocol originally created by Japanese researcher Dr.

The Tabata Method, Perfected | T Nation

https://www.t-nation.com/training/tabata-method-perfected

May 3, 2011 - This is especially true when it comes to the Tabata method, an interval training concept I first introduced to T NATION in 2004. ... First I tried the Tabata protocol with weights. ... When I first wrote about Tabata, I suggested doing thrusters, an odd front-squat-to-press variation.

The Tabata Method | T Nation

https://www.t-nation.com/training/tabata-method

Aug 24, 2004 - Fat Loss in Four Minutes. ... Enter the Tabata Method. ... The two best exercise options for the Tabata method are the front squats and the "thruster," which I'll describe in a bit.

Targeted Fat Mobilization | T Nation


https://www.t-nation.com/training/targeted-fat-mobilization


Mar 18, 2016 - Spot reduction is a myth... except when it works. Here's how to target stubborn body fatstores with specialized training.


The Ultimate Cardio Solution: Disclosed | T Nation


https://www.t-nation.com/training/ultimate-cardio-solution-disclosed


Jan 24, 2011 - The fastest fat loss possible. The most muscle retention possible. Let's do it.





How to Burn Stubborn Body Fat | T Nation


https://www.t-nation.com/diet-fat-loss/how-to-burn-stubborn-body-fat


May 6, 2014 - Two Ways To Stop Dieting. Eat Less, Exercise Less. ELEL is an approach where low intensity exercise like walking dominates and only a few sessions of weight training are done during the week. Eat More, Exercise More. The opposite of ELEL is EMEM.







References and Further Reading

Frayn, K. Regulation of fatty acid delivery in vivo. Advances in Experimental Medicine and Biology. 1998;441:171-9.

Frayn, K. Macronutrient metabolism of adipose tissue at rest and during exercise: a methodological viewpoint. The Proceedings of The Nutrition Society. 1999 Nov;58(4):877-86.

Lowery, L. Dietary fat and sports nutrition: a primer. J Sports Sci Med 2004; 3, 106-117.

Lowery, L. Chapter Four: Fat. In: NSCA's Guide to Sport and Exercise Nutrition (Campbell and Spano Eds.). Human Kinetics: Champaign, IL; 2011.

Mick, T., et al. Comparison of sports drinks on substrate oxidation during exercise. (Abstr) CCF Dept Orthopaed Surg12th Ann Res Day, Cleveland, OH 2002.

Moro, C, et al. Sex differences in lipolysis-regulating mechanisms in overweight subjects: effect of exercise intensity. Obesity (Silver Spring, Md.). 2007 Sep;15(9):2245-55.
Ormsbee, M, et al. Regulation of fat metabolism during resistance exercise in sedentary lean and obese men. Journal of Applied Physiology. (Bethesda Md.: 1985) 2009 May;106(5):1529-37.
Stallknecht B, et al. Are blood flow and lipolysis in subcutaneous adipose tissue influenced by contractions in adjacent muscles in humans? American Journal of Physiology. Endocrinology and Metabolism. 2007 Feb;292(2):E394-9.
Turcotte, L. Role of fats in exercise. Types and quality. Clinics inSports Medicine. 1999 Jul;18(3):485-98.



Friday, June 9, 2017

Is »BAIBA« the Next Big Thing in Fat Loss Supplements...‘exercise mimetic' or 'exercise in a pill'





Antaeus Labs Modular Series βAIBA is a weight-management supplement containing β-aminoisobutyric acid. β-aminoisobutyric acid (BAIBA) is a naturally-occurring amino acid that has recently been identified as an ‘exercise mimetic’ that activates a thermogenic white-fat browning program.

Further Reading:

SuppVersity - Nutrition and Exercise Science for Everyone: Is »BAIBA« the Next Big Thing in Fat Loss Suppleme...: Could BIBA be the active ingredient in a pill that solves your weight problems once and for all? Or is that too good be true? Beta-amino...

References:
  • Begriche, Karima, et al. "β‐Aminoisobutyric Acid Prevents Diet‐induced Obesity in Mice With Partial Leptin Deficiency." Obesity 16.9 (2008): 2053-2067.
  • Begriche, Karima, Julie Massart, and Bernard Fromenty. "Effects of β‐aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity." Fundamental & clinical pharmacology 24.3 (2010): 269-282.
  • Maisonneuve, Caroline, et al. "Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single-and three dual-NRTI treatments." Antimicrobial agents and chemotherapy 47.11 (2003): 3384-3392.
  • Maisonneuve, Caroline, et al. "Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting." Antiviral therapy 9.5 (2004): 801-810.


BAIBA: New Ingredient Generates Exercise in a Pill?!

https://blog.priceplow.com/baiba

May 19, 2015 - BAIBA, or 3-Aminoisobutyric Acid, was discovered as an "exercise molecule", since we produce it when we work out. Can supplementing ...


3-Aminoisobutyric acid - Wikipedia


https://en.wikipedia.org/wiki/3-Aminoisobutyric_acid


Aminoisobutyric acid is a product formed by the catabolism of thymine. During exercise, the increase of PGC-1α protein triggers the secretion of BAIBA from ...