Showing posts with label Thermogenics. Show all posts
Showing posts with label Thermogenics. Show all posts

Saturday, December 8, 2018

BAIBA | β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation

From the manufacturer:
Serving Size 2 capsules
500mg Beta-aminoisobutyric acid per Capsule
Beta-aminoisobutyric acid, or BAIBA for short.
When you exercise, benefits of that exercise are seen in many different organs of the body, not just the muscles that were exercised. These metabolic benefits are the result of “messenger” molecules that are released into the blood stream and travel to other tissues where the benefits of exercise are realised. One such messenger molecule, or “myokine”, is understood to be the amino acid beta-aminoisobutyric acid.
BAIBA is an amino acid that your body produces in response to exercise. After being released into the blood stream, it starts a thermogenic program in fat tissue, raising energy expenditure and reducing weight gain when tested in mice. When mouse or human white fat cells are exposed to BAIBA, some of them become fat-burning “beige” fat cells. Beige (or BRITE) fat cells contain the protein UCP-1 – also known as “thermogenin” because it burns triglycerides to produce heat.
– BAIBA is produced naturally by the human body – it’s formed from the catabolism of thymine [1][2] and is also product of exercise-induced PGC1a-mediated amino acid breakdown. [3]
– BAIBA increases the utilization of free fatty acids and decreases fat mass in mice. [4]
– BAIBA stimulates the differentiation of white fat cells into thermogenic beige/brite fat cells in both in vivo animal experiments and in vitro human stem cell studies. [5][6]
LGI βAIBA contains just the amino acid BAIBA. It is suitable for both men and women.
Studies suggest BAIBA may:
– Increase lipolysis and the beta-oxidation of fatty acids (“fat burning”)
– Increase body temperature and energy expenditure
– Increase ketogenesis (the production of ketone bodies in the liver)
βAIBA is suited for use by:
– those trying to lose weight, in combination with a healthy diet and exercise regime
– those trying to reap the maximal metabolic benefits from their exercise regime
– those who may be temporarily unable to exercise through injury or illness
1. β-Aminoisobutyric Acid, a New Probe for the Metabolism of DNA and RNA in Normal and Tumorous Tissue. Cancer Res 34, 1381–1384.
2. The excretion of beta-aminoisobutyric acid following thymine and dihydrothymine administration to man. Aust J Exp Biol Med Sci 39, 423–427.
3. PGC-1α-Mediated Branched-Chain Amino Acid Metabolism in the Skeletal Muscle. PLoS ONE 9, e91006.
4. Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting. Antivir. Ther. (Lond.) 9, 801–810.
5. β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors. Cell Metabolism 19, 96–108.
6. Come on BAIBA Light My Fire. Cell Metabolism 19, 1–2.


BAIBA: New Ingredient Generates Exercise in a Pill?!

https://blog.priceplow.com/baiba

May 19, 2015 - BAIBA, or 3-Aminoisobutyric Acid, was discovered as an "exercise molecule", since we produce it when we work out. Can supplementing ...

3-Aminoisobutyric acid - Wikipedia


https://en.wikipedia.org/wiki/3-Aminoisobutyric_acid

Aminoisobutyric acid is a product formed by the catabolism of thymine. During exercise, the increase of PGC-1α protein triggers the secretion of BAIBA from ...


Nov 1, 2015 - Beta-aminoisobutyric acid, aka BAIBA, is a natural catabolite of thymine. As with many other purported "next big things in fat loss supplements", ...

Friday, June 9, 2017

Is »BAIBA« the Next Big Thing in Fat Loss Supplements...‘exercise mimetic' or 'exercise in a pill'





Antaeus Labs Modular Series βAIBA is a weight-management supplement containing β-aminoisobutyric acid. β-aminoisobutyric acid (BAIBA) is a naturally-occurring amino acid that has recently been identified as an ‘exercise mimetic’ that activates a thermogenic white-fat browning program.

Further Reading:

SuppVersity - Nutrition and Exercise Science for Everyone: Is »BAIBA« the Next Big Thing in Fat Loss Suppleme...: Could BIBA be the active ingredient in a pill that solves your weight problems once and for all? Or is that too good be true? Beta-amino...

References:
  • Begriche, Karima, et al. "β‐Aminoisobutyric Acid Prevents Diet‐induced Obesity in Mice With Partial Leptin Deficiency." Obesity 16.9 (2008): 2053-2067.
  • Begriche, Karima, Julie Massart, and Bernard Fromenty. "Effects of β‐aminoisobutyric acid on leptin production and lipid homeostasis: mechanisms and possible relevance for the prevention of obesity." Fundamental & clinical pharmacology 24.3 (2010): 269-282.
  • Maisonneuve, Caroline, et al. "Mitochondrial and metabolic effects of nucleoside reverse transcriptase inhibitors (NRTIs) in mice receiving one of five single-and three dual-NRTI treatments." Antimicrobial agents and chemotherapy 47.11 (2003): 3384-3392.
  • Maisonneuve, Caroline, et al. "Effects of zidovudine, stavudine and beta-aminoisobutyric acid on lipid homeostasis in mice: possible role in human fat wasting." Antiviral therapy 9.5 (2004): 801-810.


BAIBA: New Ingredient Generates Exercise in a Pill?!

https://blog.priceplow.com/baiba

May 19, 2015 - BAIBA, or 3-Aminoisobutyric Acid, was discovered as an "exercise molecule", since we produce it when we work out. Can supplementing ...


3-Aminoisobutyric acid - Wikipedia


https://en.wikipedia.org/wiki/3-Aminoisobutyric_acid


Aminoisobutyric acid is a product formed by the catabolism of thymine. During exercise, the increase of PGC-1α protein triggers the secretion of BAIBA from ...



Monday, August 25, 2014

Product Review: PES Alphamine: Ignite thermogenesis and kickstart your fat burning



PEScience Alphamine, Cotton Candy, 8.59 Ounce

  1. Ignite thermogenesis and kickstart your fat burning
  2. Provide an instant, customizable source of clean energy
  3. Retain muscle mass and strength during the fat loss process

Most of the ingredients fall into more than one of those categories. We’ll go through the full breakdown below. Keep in mind, this isn’t in any specific order:



  1. Oregon State University; Linus Pauling Institute; “Choline;” Updated August 2009
  2. Apicella J; University Of Connecticut; “The Effect of Betaine Supplementation on Performance and Muscle Mechanisms;” May 2011
  3. Mero AA., et al.; Journal of the International Society of Sports Nutrition; “Effects of
  4. alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes;” January 2010
  5. Lang CH., et al.; American journal of physiology, endocrinology, and metabolism; “Chronic α-hydroxyisocaproic acid treatment improves muscle recovery after immobilization-induced atrophy;” August 2013
    Fujikawa T., et al.; The British Journal of Nutrition; “Chronic administration of Eucommia leaf stimulates metabolic function of rats across several organs;” December 2010
    Thom E.; The journal of international medical research; “The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people;” November-December 2007
  6. Zhang W., et al.; The American Journal of Chinese Medicine; “Eucommia leaf extract (ELE) prevents OVX-induced osteoporosis and obesity in rats;” 2012
  7. Cropley V., et al.; Psychopharmacology; “Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study;” February 2012
  8. Oi-Kano Y., et al.; Journal of nutritional science and vitaminology;” Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats;” October 2008
  9. Oi-Kano Y., et al.; The Journal of Nutritional Biochemistry; “Oleuropein supplementation increases urinary noradrenaline and testicular testosterone levels and decreases plasma corticosterone level in rats fed high-protein diet;” May 2013
  10. Anter J., et al.; Mutation Research; “A pilot study on the DNA-protective, cytotoxic, and apoptosis-inducing properties of olive-leaf extracts;” August 2011
  11. Omar SH.; Saudi Pharmaceutical Journal: SPJ: The Official Publication of the Saudi Pharmaceutical Society; “Cardioprotective and neuroprotective roles of oleuropein in olive” July 2010
  12. Astorino TA., Robertson DW.; Journal of Strength and Conditioning Research National Strength and Conditioning Association; “Efficacy of acute caffeine ingestion for short-term high-intensity exercise performance: a systematic review;” January 2010
  13. Lorist MM., Tops M.; Brain and cognition; “Caffeine, fatigue, and cognition;” October 2003
  14. Glade MJ.; Nutrition; “Caffeine-Not just a stimulant;” October 2010
  15. Westerterp-Plantenga MS., et al.; Obesity Research; “Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation;” July 2005
  16. Hursel R., Westerterp-Plantenga MS.; International Journal of Obesity; “Thermogenic ingredients and body weight regulation;” April 2010
    Goldstein ER., et al.; Journal of the International Society of Sports Nutrition; “International society of sports nutrition position stand: caffeine and performance;” January 2010
  17. Graham TE.; “Caffeine and exercise: metabolism, endurance and performance;” 2001
  18. Tarnopolsky M., Cupido C.; Journal of Applied Physiology; “Caffeine potentiates low frequency skeletal muscle force in habitual and nonhabitual caffeine consumers;” November 2000
  19. Warren GL., et al.; Medicine and Science in Sports and Exercise; “Effect of caffeine ingestion on muscular strength and endurance: a meta-analysis;”  July 2010
  20. Lee SR., et al.; Lipids in health and disease; “Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acids and energy expenditure in human subjects;” October 2013
  21. Kimura I., et al.; Japanese journal of pharmacology; “Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria;” September 1994
  22. Texas Heart Institute; “Inotropic Agents;” Updated October 2013
  23. Bai G., et al.; Acta pharmacolgica sinica; “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1;” October 2008
  24. Ostojic SM.; Research in sports medicine; “Yohimbine: the effects on body composition and exercise performance in soccer players;” October-December 2006
  25. McCarty MF; Medical hypotheses; “Pre-exercise administration of yohimbine may enhance the efficacy of exercise training as a fat loss strategy by boosting lipolysis;” June 2002
  26. http://www.ncbi.nlm.nih.gov/pubmed/22071706

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Monday, June 2, 2014

iSatori MX-LS7 Thermogenic Complex


MX-LS7 v2 is the newer even stronger, concentrated version of the original MX-LS7. Over 2 million people reached their weight loss goals using the original MX-LS7. With this new, state-of-the-art formula we want to help even more people reach their goals and get ripped. MX-LS7 v2 has been shown to convert resistant/stubborn white fat cells and turn them in to usable/dissolvable brown cells. Your fat will literally be destroying itself with MX-LS7 v2.

Nutrition Facts

Serving Size: 1 Capsule
Servings Per Container: 2
Amount Per Serving
Serving % DV
MX-LS7 Thermogenic Complex 709 mg -
Proprietary Blends
MX-LS7 Thermogenic Complex
Caffeine anhydrous, B-Phenylethylamine Hydrochloride (PEA HCI), Hemodren Hemerocallis fulva extract (flower), Advantra-Z (supplying Citrus Aurantium extract [10% para-synephrine alkaloids], N-methyltyramine, Hordenine, Octopamine, & Tyramine), red Dralion Sceletium tortuosum (standardized to contain Mesembrine), Brassica campestris extract (Whole plant), Capsitherm Capsicum annuum extract (standardized to 40,000 HU/gram), Thermo-RX Acacia Rigidula (leaf) extract (standardized to 98% Phenylethylamine alkaloids), Evodia Rutaecarpa extract (standardized for 10% Evodiamine), Mucuna pruriens (Seed) extract (standardized for 98% L-Dopa), Xanthinol Nicotinate, Sclareolide, Bioperine (piper nigrum) (Fruit), Bacopin (standardized for a minimum of 20% Bacosides A&B), Vinpocetin.
*percent Daily Values are based on a 2,000 calorie diet.
Ingredients: Gelatin, Magnesium Stearate, FD&C Red #40, FD&C Blue #1
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Nutritions Facts are a simulation of the product "Nutrition Label". For the actual Nutrition Label please refer to the product packaging.

Directions

As a dietary supplement, begin by taking one capsule per day for the first three days, 30 minutes prior to morning meal. For maximum effectiveness, after day four, take a second capsule 6 to 8 hours later, 30 minutes prior to main meal. To avoid restlessness, do not take within 4 hours prior to sleep. Please read the entire label carefully before use and follow directions. Do not exceed more than 3 capsules per day.
  

Warnings

Keep out of reach of children. Consult a physician before use. Not intended for use by persons under the age of 18. Do not exceed recommended dose. Do not consume synephrine or caffeine from other sources, including but not limited to, coffee, tea, soda, or other dietary supplements or medications containing phenylephrine or caffeine. Do not use for more than 8 consecutive weeks. Consult with your physician prior to use if you are pregnant or nursing, contemplating pregnancy, or if you are taking any medications, including but not limited to MAOI inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs, or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants. Consult your physician prior to use if you have a medical condition including but not limited to heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate, or glaucoma. Discontinue 2 weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headache, or shortness of breath.

Saturday, October 27, 2012

Man Up! Universal Animal: Real Old School Iron Big Veiny Muscle

http://www.tigerfitness.com/Universal-Animal-Pak-44-Paks-p/230001.htm&Click=61298

I love their ads. I love their shirts. And I love their products. A straight up kitchen sink approach.

Animal Pak is the king of multivitamin formulations. Multivitamin mineral blend, amino acids, a performance complex, a antioxidant complex and digestive enzymes.

Animal Stak has testosterone boosters, growth hormone support, nitric oxide (vasodilators), anti-estrogen, DHT blockers, cortisol inhibitors and liver detoxifiers.

Animal Cuts has a Thermogenic Complex, Metabolic Complex, Thyroid Complex, Diuretic Complex, Nootropic Complex, Cortisol Inhibiting Complex, CCK Inhibiting Complex, Bioavailability Complex.

Animal Flex has a Joint Construction Complex, Joint Lubrication Complex and a Joint Support Complex.

Universal products aren't made for wussy, I can't take all those pill fellas. The Animal products are made for squat til I puke, go until failure dudes who want to get big and strong.








http://www.tigerfitness.com/Universal-Animal-Pak-44-Paks-p/230001.htm&Click=61298