The below information is from the manufacturer USPLabs.
Advanced Taste
Being an IC member means you’re no stranger to the weight room. You’ve tried your fair share of pre-workouts and you probably don’t care what the product tastes like as long as it works…
So, I’m not going to waste your time trying to tell you how good this tastes…
Besides, words simply don’t do the taste justice, you’ve just gotta try it to understand how good it truly is…
We contracted industry-leading flavor scientists and gave them one very specific goal: make this the best tasting pre-workout ever…
Man did they deliver…
Additionally, the fact that these scientists were able to make it taste this good without any carbs is truly mindboggling to me…
Advanced Feel
The Rush.
The Tingle.
The unapologetic strength.
It’s like you have no choice but to simply dominate the weight room…
However, you must be warned; this bad boy is no joke…
In fact, it’s so strong we had to slap this warning label on top of the bottle:
High Energy Stim Complex Complete With Hard-Hitting Extracts
This new, precise complex targets a myriad of MOA’s for an incredible feel that so unique and strong you’ll need to time to acclimate…
Be absolutely sure to start with 1 scoop and
NEVER go over 2 at any one time...
Engineered Yohimbe Extract Standardized For Full Spectrum Alkaloids
This isn’t some run-of-the-mill “dirty” yohimbe extract…
Rather, this particular yohimbe extract is one we worked on for
months on end that contains a full spectrum of alkaloids designed to increase norepinephrine levels in order to potentially
increase muscle contraction while providing an advanced CNS stimulant effect (1).
In addition, there’s some evidence in an animal model study that the alpha 2-adrenoceptor antagonists present in the extract may also help
reduce fatigue during high intensity activity like weight lifting (2).
Norcoclaurine
The compound is known to be a beta 2-adrenoceptor agonist (3).
Some compounds also known to activate the beta 2-adrenoceptor have been shown to
improve exercise performance (4). We believe that norcoclaurine could potentially do so as well.
Yet, unlike most other beta 2 agonists, norcoclaurine has been shown to have
vasodilatory properties as well! (5).
Thus, you may have improved blood flow for additional pumps and vascularlity!
That’s a pretty sweet “bonus”!
Swertia Chirayita
This particular plant is indigenous to temperate Himilayas and has, for the most part, been their little secret…
until now!
It has specific compounds present which animal studies have shown to possess
CNS stimulant properties (6).
Caffeine
Of course, caffeine is a “must-include” in any energy formula. The key difference here is the precise amount included…
The goal here was not to simply load you up with an insane amount of caffeine so you could “feel it brah”, but to include an amount that works perfectly with the other key ingredients…
In addition to what you undoubtedly already know about caffeine, when combined with norcoclaurine, it could provide a
substantial boost to you work out session. Yet, even on its own, caffeine is thought to
potentially increase force production by each motor unit in muscle, enhancing contractile force of muscle, while reducing perceived exertion (7,8).
Advanced Performance
At the end of the day it all comes down to this one question:
“Does it work?”
It’s called “MOA domination” because so many pathways are being targeted!
Exclusive “Nitrate Blast” Formula!
Arginine Nitrate
This particular compound allows you to utilize two major pathways to generate Nitric Nxide (NO). When you ingest this compound, you get the classic arginine, which works through the classical l-arginine-NO-synthase pathway. This has proven to be a decent method to elevate NO and give you better gains in the gym and greater pumps.
Yet, this particular compound also yields the nitrate ion, which works through a recently discovered pathway, called the nitrate-nitrite-nitric oxide pathway. In essence, nitrate is reduced to nitrite, which is further reduced to NO. Yet, this second pathway is also exciting because it can generate NO via several routes that are enzymatic and non-enzymatic, making this pathway, in some respects, a more reliable and better overall way to increase NO (9-12).
Furthermore, this pathway becomes much more important and is favored over the classical pathway in conditions where oxygen levels are much lower and to some extent acidification occurs in a given tissue (e.g., anaerobic exercise such as weight lifting, sprinting, etc., where oxygen availability is lower and lactic acid is generated), allowing for vasodilation to occur and oxygen to be transported in these conditions.
By combining the two, we can utilize both pathways to obtain very high NO levels to achieve a level of vasodilation never experienced before.
Furthermore, by utilizing both pathways, you’re ensuring that NO levels can remain elevated regardless of the phase of your activity.
This increased NO and vasodilation may at least be partially responsible for a potential improvement of exercise efficiency by reducing the amount of oxygen and energy needed in the form of ATP and phosphocreatine during exercise and muscle contraction.
In short, it may allow you to be more resistant to fatigue and squeeze out a little more during your workouts, whether that’s just a few more reps when weightlifting or allowing you to stay in the game a little longer.
Though, this isn’t just hype; in fact, a recently published study found that nitrate can increase force production in fast-twitch skeletal muscle in mice used as an animal model. This is further corroborated by the fact that one paper in humans found that nitrate supplementation allowed for a prolonged maintenance of force production (14,21).
It’s also worth noting that this notion of nitrate increasing vasodilation and improving exercise performance isn’t just hypothetical. Several studies have surfaced recently which have demonstrated that nitrate can and does accomplish just that (13-20).
In fact, a recent meeting summary by leading researchers of nitrate’s and NO’s potential by commenting that the apparent enhancement of skeletal muscle efficiency seen as a reduced oxygen cost of exercise is seen from low to high-intensity exercise and in recreationally active and moderately trained subjects (22).
Pinus Pinaster Bark Extract
This extract may further increase the conversion of nitrite to NO, while also increasing eNOS expression and NO formation, thus helping both NO generating pathways.
Vitamin C (Ascorbic acid)
Vitamin C is known to play a role in maintaining NO bioactivity/bioavailability and is the reason why it is known to improve the effects of NO, whether the NO is derived from arginine or the reduction of nitrite (23-25).
Studies suggest that vitamin C can work synergistically with the other key ingredients by improving upon both major NO-generating pathways; of particular interest is that it (as a reducing agent) can also increase the amount of NO produced from nitrite while also enhancing the level of vasodilation; yet, it also plays a role in the function of eNOS by acting to recycle tetrahydrobiopterin, a cofactor for eNOS (26,27).
You’re Not Still Getting Ripped Off By Creatine HCl, Are You?
Advanced Creatine Ratio: Monohydrate and Anhydrous
Everyone knows that creatine is able to improve body composition and strength. It’s easily one of the most validated supplements around. It works and has always worked. Yet, many companies want to sell you a creatine complex, a supposedly superior salt, a new ester, you name it, claiming it will provide superior results over tried and true creatine…
They make such claims
with no scientific evidence (even though they will pretend it exists)…
They claim that bioavailability is a problem with creatine monohydrate due to lack of dissolution in the GI tract. Yet, scientific studies show otherwise…
In fact, despite what bro science says,
the absorption of the creatine monohydrate salt is nearly 100% (28-30).
This begs the simplest question; if the oral bioavailability of creatine monohydrate is already close to 100%, how can it be significantly improved upon?
The simple answer is
that it can’t be improved upon. It’s like someone claiming they can fill the 13 gallon tank in your car with more than 13 gallons of gas…
It doesn’t matter how much more soluble you make your creatine product if creatine monohydrate already has nearly 100% bioavailability.
If dissolution rate isn’t a rate-limiting step for the compound, then improving solubility does nothing for bioavailability…
…You simply have a neat party trick to show friends how much creatine you can dissolve in a glass of water…
Yet, just as important to consider is the fact that skeletal muscle can only absorb and store a limited amount of creatine (28-31). So, even if we were to ignore the fact that oral bioavailability of creatine monohydrate has little to no room for improvement, we must then consider the fact that the muscle can only transport so much creatine and tissue saturation is going to occur regardless at some point.
So, regardless of which form is used, only so much creatine is going enter into the muscle and saturation is going to be reached at some point…
…For example, it’s thought that a 154 lb person has a total creatine content in skeletal muscle of approximately 115 grams, with a total creatine pool of approximately 120 grams (30,31).
And for a specific example, a subject that was given 340 grams of creatine monohydrate over a 34 day period of time only retained 38 grams in the body. Or, in another subject that was given 270 grams, only 58 grams were retained (31). Studying the kinetics of creatine has provided support for this as well (28-30).
In effect, this demonstrates again that skeletal muscle can only hold so much creatine and it isn’t all that much higher than the baseline levels…
Once Again, Bro Science Jumps Up To Get Beat Down
So, even if we were to ignore the fact that the absorption of creatine from the small intestine is thought to be close to 100% and believe the marketing from those selling these supposedly superior forms of creatine, the higher levels of creatine in the bloodstream would make little difference as skeletal muscle can only absorb and store a limited amount of creatine…
Consequently,
higher plasma levels of creatine don’t mean that it will translate to higher levels of creatine in muscle…
Ultimately, the level of creatine in muscle would need to be substantially higher in order for these other creatine products to be classified as being superior to creatine monohydrate and most importantly of all; this higher level of creatine would need lead to a significant improvement upon lean body mass, strength and power.
Yet, conveniently, a study comparing the effects of these creatine formulations versus standard creatine monohydrate upon these parameters has not been sought out or published…
Makes ya think, doesn’t it?
Ahh, But What If You Could Make Your Creatine More Pure?
It’s like Pippen With Jordan!
If improving solubility doesn’t matter, what about your creatine being more pure? Some manufacturers like to claim that their creatine form is concentrated because of the salt they use…
But that’s a bunch of malarkey because
creatine monohydrate is already nearly 88% pure creatine (88% creatine, 12% monohydrate salt)…
That’s nearly 10% more pure than products like Creatine HCl!
But, what if I told you there is a form of creatine that is 100% creatine? Would you want that in your pre-workout?
Of course you would and that’s exactly why we included it in Jack3d “Advanced Formula”!
It has the same, if not slightly better solubility than creatine monohydrate but provides about 12% more creatine.
You can’t get any more pure than creatine anhydrous!
Beta-Alanine
Beta-alanine serves as the rate-limiting precursor of carnosine and as such, it has been shown that by supplementing with beta-alanine, you can greatly increase carnosine levels in skeletal muscle tissue.
It’s so important because it acts as a buffer of sorts, preventing the increase of acidity or Hydrogen ion accumulation in skeletal muscle; something which is thought to contribute to the fatiguing of muscles.
Furthermore, there is evidence that by increasing carnosine levels, power output can be increased as well. In short, you are able to improve your power out, while also delaying fatigue.
Simply put, you can lift more explosively and for longer periods (32-35).
It is no coincidence that the most explosive athletes (e.g. sprinters) have higher carnosine levels in their muscles. Looking to the animals of our world provides us with yet another example;
the most explosive animals such as greyhounds and thoroughbred horses also have the highest level of carnosine in their muscle tissue.
In short, beta-alanine supplementation has been shown to be an effective way of elevating carnosine levels in muscle.
Consequently, it has been shown to increase the working capacity of muscle, elevate the buffering capacity of muscle, elevate the anaerobic threshold of muscle, promote endurance, delay fatigue during workouts, enhanced exercise training, and result in an overall improvement of muscle performance.
If you think beta-alanine isn’t necessary, you should also consider the fact that it is believed that
muscle carnosine levels generally decline with age and are thought to be lower in those that don’t consume much meat in their diets (34).
The benefits of supplementing with beta-alanine are pretty obvious, just like this “insane in the membrane” offer…
