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Directions For Energize: For all day energy
and to reduce fatigue, take 2 tablets, once or twice per day, always with a full
glass of water. For maximum energy, take 3 to 4 tablets 30 minutes before
exercise or physical activity. Do Not Exceed 4 Tablets In Any 8-Hour Period.
Warnings: Consult with your primary
physician prior to use if you have any pre-existing medical conditions,
including high blood pressure, thyroid problems, nervous disorders, or if you
are using MAO inhibitors or taking any prescription drug. Individuals who are
sensitive to caffeine should begin use with one-half the recommended dosage and
limit the use of other caffeine-containing foods and drinks while taking this
product because too much caffeine may cause nervousness, irritability, and
sleeplessness. Do not use if pregnant or lactating. Not intended for use by
persons under 18.
* These statements have not been evaluated by the Food
and Drug Administration. This product is not intended to diagnose, treat, cure,
or prevent any disease.
Supporting Studies:
Ziegenfuss, T.N., Mendel R.W., and Hofheins, J.E. Acute Metabolic Responses to Energize™ Administration in Healthy Men and Women. Ohio Research Group. Wadsworth, Ohio 44281, USA.
One of the first steps in examining the safety and efficacy of dietary supplements designed to increase mental acuity, performance, and energy is to characterize the physiological responses to acute administration. Objective : The purpose of this placebo-controlled, double-blind clinical trial was to determine the effects of acute (single-dose) Energize™ supplementation in healthy men and women. Methods : After giving informed consent and being cleared for participation by passing a screening physical, ten healthy men [mean ± SD age, height, weight (36.8 ± 1.2 y, 179.2 ± 2.8 cm, 88.3 ± 16.6 kg)] and ten healthy women (35.2 ± 6.9 y, 169.6 ± 4.3 cm, 61.6 ± 3.9 kg)] completed two trials using a counterbalanced design. Measurements of resting metabolic rate (RMR) and substrate oxidation, assessed via indirect calorimetry (Parvo Medics TrueMax 2400), were made at baseline (pre-ingestion) and for 10 minutes at the end of each hour for two hours post-ingestion; systemic cardiovascular activity (resting heart rate and blood pressure) were measured at 0, 30, 60, 90, and 120 minutes post-ingestion; and Profile of Mood States (POMS) were measured pre and 120 minutes post-ingestion. Results : Two-way ANOVA revealed a significant interaction (p<0.00004) for RMR between conditions. Specifically, ingestion of Energize™ caused a statistically significant increase in RMR at 60 min (11%; from 3.92 ± 0.32 to 4.35 ± 0.22 ml/kg/min, P<0.0001) and 120 min (14%; from 3.92 ± 0.32 to 4.46 ± 0.33 ml/kg/min, P<0.0001) compared to the placebo trial. No changes in heart rate, blood pressure, or POMS were noted between trials. Conclusions: These preliminary findings indicate that a single dose (2 tablets) of Energize™ safely and effectively increases RMR for at least two hours post-ingestion. Future research should: 1) determine how long RMR remains elevated from acute Energize™ administration; and 2) assess the effects of chronic Energize™ supplementation on body weight, body composition, and exercise performance.
Data are expressed as mean ± 95% confidence intervals. *Significantly greater (P<0.0001) than baseline and corresponding placebo value.
This study was funded in part by a research grant from iSatori (Golden, CO).
