Showing posts with label Threonine. Show all posts
Showing posts with label Threonine. Show all posts

Monday, October 8, 2018

Silk Amino Acids


Silk amino acids have been a part of Chinese medicine for thousands of years and now the western world bodybuilding has jumped on board.



Silk amino acids or SAA are comprised of primarly of 5 short chain proteins in the below proportions.





Predominant composition of silk amino acids (by weight*)


•L-Alanine (34.36%)


•Glycine (27.23%)


•L-Serine (9.58%)


•L-Valine (3.49%)


•L-Threonine (2.00%)


•[*SAAs contains other amino acids but only those representing >2.00% are listed due to their greater relevance]





^ Shin S, Park D, Yeon S et al. Stamina-enhancing effects of silk preparations in mice. Lab Anim Res 2009;25:127–34.

BPI Blox gives SAA SEQUENCED PROTEINS™ in a 3,960mg serving containing Alanine, Glycine, Serine, Valine, and Threonine.



The reported benefits are as follows.


A recent animal study, found that when exercising mice were given three different doses of silk amino acids for 44 days, the mice experienced:



Improved exercise performance
SAA fed mice exercised more than twice as long as mice not fed SAAs (28 minutes vs 13 minutes)
In terms of absolute improvement in exercise performance, SAAs produced improvements that were six times greater than that seen with just exercise (18 minute increase compared to 3 minute increase)
Eliminated the increase in blood lactate levels (which were significantly increased with just exercise)
Eliminated the increase in muscle oxidation (which was also significantly increased with just exercise)
Maintained blood glucose levels (vs being significantly lowered in exercising mice)
Increased muscle glycogen and liver glycogen (compared to exercise alone)
Increased testosterone levels (64% increase vs 36% reduction in exercise group; in absolute terms, blood testosterone levels that were 2.6 times higher in SAAs group compared to exercise group)
Reduced cortisol (140% increase in cortisol in exercising group while no significant increase was seen when SAAs were given)
Increased anabolic ratio (4-fold higher anabolic ratio; ie, the testosterone to cortisol ratio compared to mice not receiving any)
Increased muscle size (16% increase with high-dose)



Other effects of silk amino acids (SAAs) or silk protein hydrolysates include regulating the immune system, lowering muscle and liver damage, as well as having anti-tumor, and anti-viral effects.

1.Shin S, Yeon S, Park D et al. Silk amino acids improve physical stamina and male reproductive function in mice. Biol Pharm Bull 2010;33:273–8.
2.^ Ryu JM, Kim TM, Seo IK et al. Effect of repeated administration of silk peptide on the immune system of rats. Lab Anim Res 2008;24:361–9.
3.^ Kim TM, Ryu JM, Seo IK et al. Four-week repeated-dose toxicity of silk amino acids in rats. Lab Anim Res 2008;24:565–73.
4.^ Zhaorigetu S, Yanaka N, Sasaki M et al. Silk protein, sericin, suppresses DMBA-TPA-induced mouse skin tumorigenesis by reducing oxidative stress, inflammatory responses and endogenous tumor promoter TNF-alpha. Oncol Rep 2003;10:537–4.
5.^ Gotoh K, Izumi H, Kanamoto T et al. Sulfate fibroin, a novel sulfated peptide derived from silk, inhibits immunodeficiency virus replication in vitro. Biosci Biotechnol Biochem 2000;64:1664–70.




LINKS:
Is There a Silky Way to a Leaner, Healthier You? BPI Sports Introduces the First Silk Protein Supplement to the Market

Fat Burning Silk Peptides From Korean Labs: You Don't Even Have to Eat Worms to Gear Your Personal Energy-In-VS-Energy-Out Equation Towards Weight & Fat Loss







Thursday, December 21, 2017

Threonine

L-Threonine

L-Threonine is an essential amino acid that cannot be synthesized by humans and has to be obtained from dietary sources. L-Threonine supports cardiovascular, liver, central nervous, and immune system function. L-Threonine aids in the synthesis of glycine and serine, two amino acids that help in the production of collagen, elastin, and muscle tissue. L-Threonine helps build strong bones and tooth enamel. It also speeds up wound healing after injury by boosting immune system.

L-Threonine combines with the amino acids aspartic acid and methionine to help liver digest fats and fatty acids, which reduces accumulation of fat in the liver. An accumulation of fats in the liver can affect negatively its function.

L-Threonine is useful in treating Lou Gehrig's Disease, also known as Amyotrophic Lateral Sclerosis (ALS). Research shows that symptoms of Multiple Sclerosis (MS), another disease that affects nerve and muscle, may be alleviated with L-Threonine treatment. L-Threonine is an immunostimulant, which promotes the growth of thymus gland.

L-Threonine typically found in high concentrations in the heart, skeletal muscles and central nervous system. L-Threonine is required to help maintain the proper protein balance in the body, as well as assist in the formation of collagen and elastin. It is further involved in liver functioning including fighting fatty liver. L-Threonine plays a role lipotropic functions when combined with aspartic acid and methionine as well as assisting the immune system by helping the production of antibodies and promotes thymus growth and activity.

Other nutrients are also better absorbed when L-Threonine is present, and it has also been used as part treatment of mental health. Good levels of L-Threonine are found in most meats, dairy and eggs, as well as in lower quantities in wheat germ, nuts, beans and some vegetables.

Sources:
Essential amino acid From Wikipedia, the free encyclopedia


Tuesday, April 8, 2014

What's in Body Fortress Super Advanced Whey Protein? aka Walmart Protein

If your budget is tight then I would suggest heading to Walmart and buying the Body Fortress Super Advanced Whey Protein. Why? Because for around $15 you will be set for a month. There's 20 - 21 servings which means that if you workout 5 times per week it should last.

I would recommend 1 scoop mixed with milk post-workout. That would get you upwards north of 40 grams of protein. The milk will add some slow digesting protein to go along with the fast whey in the powder.

In addition to the whey blend, Body Fortress offers some added amino acids and creatine.

Glycine
From Nutrabio - Glycine is a conditionally essential amino acid that has one of the simplest structures of all the amino acids found in the body. Glycine is found in proteins of all life forms, and is important for the synthesis of proteins as well as adenosine triphosphate (ATP).

Creatine
Made from the three amino acids arginine, glycine, and methionine. It helps the body regenerate ATP allowing you to keep pushing up weight. Creatine supplementation also helps pull fluid into muscle. The fluid within muscle which expands the tissue and gives it fullness.

Taurine
Pulls fluid in the muscle expanding the tissue creating greater potential for growth. The second most abundant amino acid in muscle.

Threonine
From Nutrabio - Threonine combines with the amino acids aspartic acid and methionine to help liver digest fats and fatty acids, which reduces accumulation of fat in the liver. An accumulation of fats in the liver can affect negatively its function.

Glutamine
Recovery and anti-catabolic amino acid. The most abundant amino acid in muscle tissue.

BCAA (Leucine, Valine, Isoleucine)
Branch Chain Amino Acids are the keys to the start of protein synthesis. Bypassing the liver they go straight to the bloodstream starting a cascade of metabolic process resulting in muscle gains.
Read more here.

Product Label
1.95 Lbs.Chocolate
Supplement Facts
Serving Size1Scoop(42g)
Servings Per ContainerAbout 21
Amount Per Serving% Daily Value
Calories170
Calories From Fat25
Total Fat2.5g3%†
Saturated Fat1.5g6%†
Cholesterol70mg17%
Total Carbohydrate7g1%†
Dietary Fiber<1g4%†
Sugars2g††
Protein30g60%†
Calcium72mg7%
Iron0.5mg3%
Phosphorus74mg7%
Magnesium23mg6%
Zinc0.09mg1%
Copper0.05mg3%
Sodium100mg4%
Potassium210mg6%
† Percent Daily Values are based on a 2,000 calorie diet
†† Daily Value not established
Ingredients:
Super Whey Protein Blend (Whey Protein Concentrate, Whey Protein Isolate), Super Recovery Blend (Glycine, Creatine Monohydrate, Taurine, Threonine, L-Glutamine, Leucine, Valine, Isoleucine), Maltodextrin, Cocoa (Processed With Alkali), Natural And Artificial Flavors, Soy Lecithin, Cellulose Gum, Acesulfame Potassium, Sucralose.
Contains Milk And Soy Ingredients.
Gluten Free

Directions For Super Advanced Whey Protein: For Adults, Add One (1) Scoop (42g) To 6-8 Ounces Of Water Or Your Favorite Beverage Daily. Serious Athletes And Bodybuilders (Over 125 Pounds) Should Consume 1-2 Scoops Immediately After Exercise.
Blender - Simple: Cover And Blend For 20-30 Seconds.^^
Shaker - Simpler: Cover And Shake For 25-30 Seconds.
Glass & Spoon - Simplest. Stir For 20-30 Seconds Or Until Completely Blended.
^^For Mass Gaining: Add Higher Calorie Foods Such As Peanut Butter, 1-2% Milk, And Fruit Juices. For Dieters: Add Lower Calorie Foods Such As Skim Milk Or Just Use Water.

Warnings: Not intended for use by pregnant or nursing women. If you are taking any medications, consult your doctor before use. Avoid this product if you have kidney disease. Discontinue use and consutl your doctor if any adverse reactins occur.
KEEEP OUT OF THE REACH OF CHILDREN. KEEP IN A DRY PLACE, TIGHTLY CLOSED AND AVOID EXCESSIVE HEAT. FOR YOUR PROTECTION, DO NOT USE IF SEAL UNDER CAP IS BROKEN OR MISSING.


* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
 



Tuesday, October 29, 2013

The Amino Acid Profile of Human Muscle Tissue

I have no idea whether this information is relevant to muscle building or protein intake but thought that is was interesting enough to share. Even though leucine is a small percentage of muscle tissue it is still key to signaling protein synthesis. It appears that leucine has the ability to bypass usage in the gut and the liver leading to high blood levels. The high blood levels signals the mTor pathway to initiate protein synthesis.


The concentration is in Molar concentration (mM) .

Source:
Amino acids in skeletal muscle: Are protein supplements as good as advertised?
Optimal protein intake to maximize muscle protein synthesis - Biolayne [PDF]
Episode 2 of Muscle College Radio: Muscle Protein Synthesis ...




Amino Acids - structure, advantages, properties, classification









Tuesday, April 30, 2013

The 9 Essential Amino Acids

True Nutrition EAA's - Essential Amino Acids Powder (500gm)

L-Histidine

L-Histidine is an essential amino acid, which converts to histamine, a powerful blood vessel dilator, involved in gastric acid secretions and neurotransmission in the central nervous systems. It is also related to circadian rhythms, sexual arousal and orgasmic function in women.

L-Histidine is needed for growth and for the repair of tissue, as well as the maintenance of the myelin sheaths that act as protector for nerve cells. It is known to help protect the body from damage caused by radiation and also helps in removing heavy metals from the body. L-histidine is also required by the body to regulate and utilize essential trace minerals such as copper, zinc, iron, manganese and molybdenum.

L-Histidine is precursor to the allergy symptom producing hormone histamine. Histamine is well known for its role in stimulating the inflammatory response of skin and mucous membranes such as those found in the nose - this action is essential in the protection of these barriers during infection.
Histamine also stimulates the secretion of the digestive enzyme gastrin. Without adequate histamine production healthy digestion can become impaired. Without adequate In the stomach, L-Histidine can be helpful in producing gastric juices. People with a shortage of gastric juices or suffering from indigestion, may also benefit from this nutrient. L-Histidine is also required by the body to regulate and utilize essential trace minerals such as copper, zinc, iron, manganese and molybdenum.
L-Histidine is one of the glucogenic amino acids. Glucogenic amino acids facilitate the body's production of energy. L-Histidine is used to help boost the production of red and white blood cells.

Isoleucine

Isoleucine is an essential amino acid that along with leucine and valine makeup the branched chain amino acids (BCAA). This amino acid cannot be manufactured in the body, and needs to be supplied in the diet. Isoleucine is thought to play the biggest role in increasing endurance and helping heal, repair and grow muscle tissue damaged from injury and strenuous exercise and training. Isoleucine is especially important to serious athletes and body builders because of its role in boosting energy production and assisting the body recover from strenuous physical activity.
Isoleucine, together with the other two branched-chain-amino-acids promote muscle recovery after physical exercise and on its own it is needed for the formation of hemoglobin as well as assisting with regulation of blood sugar levels as well as energy levels. It is also involved in blood-clot formation.

Therapeutic doses of isoleucine may be very helpful in preventing muscle wasting and promoting tissue repair after surgery or trauma. Substantial evidence in the literature supports the anabolic effects of branched-chain amino acids on muscle protein synthesis. Supplementation with isoleucine may, therefore, have a positive effect on increasing muscle protein in those who are suffering from muscle protein loss. Amen and Yoshumira have presented evidence which indicates that isoleucine, leucine, and valine are important for stimulating anabolic function in humans. Isoleucine is also converted in the liver to blood sugar; therefore, it can be helpful in maintaining proper blood glucose levels. Therapeutic doses of isoleucine range between 200 to 2,000 mg per day.

L-Leucine

L-Leucine is an essential amino acid, meaning it cannot be made by the body, and must be acquired through food or dietary supplements. Leucine is classified as a branched-chain amino acid (BCAA). It comprises about 8% of the total amino acid count in your body's protein structures and is the fourth most concentrated amino acid in skeletal muscle tissue.

L-Leucine stimulates muscle protein synthesis and may be the major fuel involved in anabolic (tissue building) reactions. This makes them especially important for body builders and other athletes in sports that demand explosive strength.

The branch chain amino acids valine, leucine, and isoleucine enhance protein synthesis in liver cells and muscle cells and help promote muscle recovery after exercise. They contribute to energy production in the body by being oxidized in the cell's mitochondria. Branch chain amino acids are used by body builders and athletes to produce an anabolic effect and assist in the repair of micro tears in muscle tissue that are a normal result of exercise. Leucine is thought to be the most effective BCAA for preventing the body's burning of muscle stores for energy during intense workouts because it is converted to glucose more quickly than isoleucine and valine.

Lysine

Lysine is an essential amino acid, which means your body cannot manufacture it so it must be obtained through the diet or by supplementation. Lysine is an essential component of all proteins and works with other essential amino acids to maintain growth, lean body mass, and the body's store of nitrogen.

Lysine acts as a precursor for several other amino acids, including L-Citrulline (needed for normal protein metabolism) and L-carnitine (needed for fat metabolism). Lysine is crucial for the formation of collagen, a major part of the body's connective tissues and appears to help the body absorb and conserve calcium and may reduce its excretion.

Lysine contributes to energy production when converted to acetyl coenzyme A, one of the principal fuels for the Krebs cycle. Lysine is needed for growth and to help maintain nitrogen balance in the body. L-lysine has many other functions in the body because it is incorporated into many proteins, which are used by the body for a variety of purposes. Lysine supports a healthy immune system.

L-Methionine

L-Methionine (methionine) is a sulfur-bearing essential amino acid, which means that it cannot be manufactured by the body and must be obtained through diet or by supplementation. L-methionine is an antioxidant found in meat and dairy products and supplementing with it is especially recommended for people on a vegetarian diet.

L-Methionine acts as a methyl donor in biochemical pathways and can be converted to SAMe (S-adenosyl methionine), a natural compound that supports liver function, healthy joints, and is necessary for normal brain function. S-adenosyl methionine, a precursor to phosphatidyl choline and creatine. Phosphatidyl choline, an important component of cell membranes, supports healthy brain function. Creatine forms creatine phosphate, a high-energy compound found in high concentration in the muscles. Creatine phosphate helps regenerate ATP during exercise, providing energy for short bursts of maximal muscle power.

In the body, methionine is converted to L-Cysteine and is potentially beneficial in liver detoxification and in neutralizing toxins. L-Cysteine is a component of the cellular antioxidant glutathione, an important antioxidant molecule in the body which assists in natural detoxification processes. L-methionine is also a transporter of the antioxidant mineral, selenium.

L-Methionine has been shown to support healthy copper and lead serum levels, liver fat metabolism, healthy skin and nails, and energy production. High purity, free form l-methionine is well tolerated.
L-Methionine is one of the nine essential Amino Acids necessary for balanced nutrition and good health. Amino Acids provide the crucial building blocks for protein. Protein plays a role in constructing and maintaining the critical structures and functions of the body.

L-Phenylalanine

L-Phenylalanine is an essential nine-carbon amino acid that is one of the most commonly found aromatic amino acids that exhibit ultraviolet radiation absorption properties. L-Phenylalanine can be converted to L-tyrosine by a complex biochemical process which takes place in the liver. L-Tyrosine in turn is used to synthesize two important neurotransmitters; dopamine and norepinephrine. These hormones are depleted by stress, overwork and certain drugs. By replenishing norepinephrine in the brain, mental energy levels are enhanced and a feeling of contentment often occurs. In addition, the conversion step from L-tyrosine to norepinephrine may be enhanced if the cofactors vitamins B6 and C are present.

Phenylalanine is available in three different forms, L-, D-, and DL-. The L- form is the most common and the type in which it is incorporated into the body's proteins. The D- form acts as a painkiller and the DL- acts as a combination of the two. L-Phenylalanine is used in elevating the mood since it is so closely involved with the nervous system. This amino is also said to help with memory and learning, and some people use it as an appetite suppressant. Toxicity is rare but large amounts of L-Phenylalanine may affect your blood pressure and cause headaches, nausea and heartburn.
By contributing to the synthesis of dopamine and norepinephrine, Phenylalanine may also help to regulate appetite by promoting a healthy mood.



L-Threonine

L-Threonine is an essential amino acid that cannot be synthesized by humans and has to be obtained from dietary sources. L-Threonine supports cardiovascular, liver, central nervous, and immune system function. L-Threonine aids in the synthesis of glycine and serine, two amino acids that help in the production of collagen, elastin, and muscle tissue. L-Threonine helps build strong bones and tooth enamel. It also speeds up wound healing after injury by boosting immune system.

L-Threonine combines with the amino acids aspartic acid and methionine to help liver digest fats and fatty acids, which reduces accumulation of fat in the liver. An accumulation of fats in the liver can affect negatively its function.

L-Threonine is useful in treating Lou Gehrig's Disease, also known as Amyotrophic Lateral Sclerosis (ALS). Research shows that symptoms of Multiple Sclerosis (MS), another disease that affects nerve and muscle, may be alleviated with L-Threonine treatment. L-Threonine is an immunostimulant, which promotes the growth of thymus gland.

L-Threonine typically found in high concentrations in the heart, skeletal muscles and central nervous system. L-Threonine is required to help maintain the proper protein balance in the body, as well as assist in the formation of collagen and elastin. It is further involved in liver functioning including fighting fatty liver. L-Threonine plays a role lipotropic functions when combined with aspartic acid and methionine as well as assisting the immune system by helping the production of antibodies and promotes thymus growth and activity.

Other nutrients are also better absorbed when L-Threonine is present, and it has also been used as part treatment of mental health. Good levels of L-Threonine are found in most meats, dairy and eggs, as well as in lower quantities in wheat germ, nuts, beans and some vegetables.

L-Tryptophan

L-Tryptophan is an essential amino acid important for the synthesis of melatonin and serotonin which are hormones that regulate mood and stress response. L-Tryptophan helps support relaxation, sleep, positive mood and immune function. L-Tryptophan is the precursor to Serotonin, a neurotransmitter in the brain, which is deficient in people who have depression. L-Tryptophan also supports immune functions because it is the body's precursor to the kynurenines that regulate immunity. If needed, L-tryptophan converts to niacin in the body, which supports circulation, a healthy nervous system, the metabolism of food, and the production of hydrochloric acid for the digestive system. As an essential amino acid, it is not synthesized by the body and must be obtained from the diet.

L-Tryptophan for Dieting:

During dieting, L-Tryptophan levels and serotonin levels drop dramatically. These low serotonin levels in overweight and obese patients are known to cause carbohydrate cravings and the resultant binge eating. Because brain and blood levels of serotonin, rise and fall depending on the amount of L-Tryptophan you consume, many health practitioners use L-Tryptophan to stop the cravings and help diets succeed. Numerous clinical trials on overweight patients have demonstrated food cravings decrease, and food intake decreases when serotonin levels are high. Tryptophan is necessary for the production of niacin. It is used by the brain to produce serotonin, a neurotransmitter that transfers nerve impulses between cells and is responsible for normal sleep. L-Tryptophan helps to combat depression and insomnia and to stabilize moods. It helps to control hyperactivity in children, alleviates stress, is good for the heart, aids in weight control by reducing appetite, and enhances the release of growth hormone. It is good for migraine headaches and may reduce some of the effects of nicotine.

L-Valine

L-Valine is an essential amino acid, specifically classified as a branched-chain amino acid (BCAA). BCAA's, which include valine as well as leucine and isoleucine, stimulate protein synthesis directly in muscle tissue. Valine works in the body as a fuel involved muscle-tissue building reactions, and stimulates muscle protein synthesis. Valine helps optimize the body's metabolism, providing energy and assistance with the repair and growth of damaged tissues. It has a stimulating effect and is needed for muscle metabolism, repair and growth of tissue and maintaining the nitrogen balance in the body.
Valine, helps stimulate the central nervous system and is needed for proper mental functioning. Valine may also improves liver function by assisting with removal of potentially toxic excess nitrogen from the liver and aids in nitrogen transport to other tissues in the body as needed. Increased valine intake may improve liver function for Individuals with various types of liver disease and liver damage from alcohol or drug abuse.

L-Valine is an essential amino acid that cannot be made in the body and must be acquired through food or dietary supplements.

Sources:
Essential amino acid From Wikipedia, the free encyclopedia