Tuesday, September 4, 2012

The New Muscletech Hydroxycut Hardcore Elite combines Green Coffee Bean and Forskolin (Coleus forskohlii)

Has Muscletech done it again? Is this the industries new best fatburner? Maybe....only time will tell.

I have not tried it yet but will. It has the combination of stuff that could make it the best. A synergistic combination of ingredients that should speed you on your way to rip city.

I love the ingredients, not loving the price. However, if you were to buy all of the ingredients separately, you'd pay more.

Let's break it down.

CAFFEINE

Frees up fat and boosts your metabolism to burn that freed fat.

FORSKOLIN

Activates the enzyme adenylate cyclase that allows fat cells to be broken down and used as fuel. Forskolin also increases testosterone production at the source.

GREEN-COFFEE EXTRACT

Contains chlorogenic acid which has been shown in several clinical studies to lead to significant fat loss. It works with caffeine to do this while also lowering the impact of post meal blood sugars.

COCOA EXTRACT

Cocoa provides theobromine, an active metabolite of caffeine that provides fat-burning effects similar to caffeine.

YOHIMBE

Yohimbine and rauwolscine bind to fat cells removing limits to the amount of fat burned.
 

Source Citation (MLA 7th Edition)



Stoppani, Jim. "Muscletech hydroxycut hardcore elite: an up-close look at muscletech's clinically supported fat burner." Joe Weider's Muscle & Fitness May 2012: 76. Academic OneFile. Web. 4 Sep. 2012.






Monday, September 3, 2012

7 Steps to Higher Testosterone


High T. Everyman wants it. It means power, energy, virility culminating in the ultimate swagger man. After the age of 30 your testosterone levels begin to drop and continue to drop. Nice thought. If you are under 30 then you don't need the seven steps, just follow the first two.

The normal range is 300-1,200 ng/dL. Typically low testosterone is considered below 280 ng/dL, but most will say that if you drop below 400 you need help.

How do you achieve it? Diet and exercise of course are the platform for your launch. Decreasing fat stores and keeping stress hormones at bay also will help.

There are seven steps you need to complete in order to maximize your testosterone production and use.
Yup, “Ancient Sea Salt” would be a scientifically accurate branding for ordinary table salt.
— Neil deGrasse Tyson (@neiltyson) August 16, 2015

I'm not the most verbose dude so let's jump right in.

1) Eat for Higher T.
    Eat like a freakin man. Whole eggs, beef, nuts. Almonds, brazil nuts and
    cod liver oil. Avocados and olives. Oysters if you can handle it. The
    saturated fat is required. The body uses cholesterol to produce testosterone.
    Sprinkle in a few servings of cruciferous vegetables (broccoli, cabbage, kale
    and collards) keeps your testosterone from becoming estrogen. Grass fed
    beef contains higher levels of CLA which has some value for fat burning
    and anti-aromataze. Drink black tea or real cocoa they lowers cortisol.
    Add wheat germ to your shakes to get teste supporting zinc. Raw honey
    containing atleast 25mg of royal jelly.

2) Lift Heavy and Lift Late
    Heavy compound movements (either heavy 6-8 reps or high reps with
    short rest). Squats and deadlifts should lead the way. Pull-ups, shoulder
    press, bench press, bent-over rows. Why late? Because the stress
    hormone cortisol is higher in the morning and the higher your cortisol
    the lower your testosterone.

3) Increase Luteinizing Hormone (LH). 
Take one of the following. Go five days on/two days off for eight weeks, then take  two weeks off.

    Tribulus terrestris - Take 500-2,000 mg per day in 2-3 divided doses. One dose 30-60 minutes pre-workout.

    D-Aspartic Acid - 3 grams first thing in the morning

    Fenugreek Extract - Take 500-2,000 mg per day.

    Avena sativa -100-250 mg 1-2 times per day, with one dose about 30-60 minutes before your workout.
        
4) Stimulate the Testicles Leydig Cells. 
Go five days on/two days off for eight weeks, then take two weeks off.

     Eurycoma longifolia Jack (Longjax aka Tongkat ali) - 200-300 mg 2 -3 times per day.

     Forskolin (Coleus forskohlii) - Take 20-50 mg 2-3 times daily.

5) Prevent Aromatase (what good is testosterone if it converts into estrogen)
     
Chrysin (also known as 5,7-di-hydroxyflavone) - 1g with breakfast, lunch,  and the last meal of the day
     
Damiana extract - 50-500mg of three times per day in between meals

Diindole or Diindolylmethane (DIM) - 200-300mg in two or three divided doses

6) Free the Testosterone - testosterone can't enter muscle unless it's free from sex-hormone-binding globulin (SHBG)

    Stinging nettle root (urtica dioica) - 100-500 mg of stinging nettle root extract 2-3 times per day on an empty stomach.

    Boron - 10 mg per day was shown to increase free testosterone by almost 30% while also lowering estradiol goes down by forty percent.

    Avena Sativa - see step 3

    Eurycoma longifolia Jack (Longjax aka Tongkat ali) - see step 4
    
7) Increase Your Androgen Receptors - that free testosterone now has to enter muscle tissue.

Carnitine - 1-3 grams of  in the form of L-carnitine, acetyl-L-carnitine or L-carnitine-L-tartrate with breakfast and pre and post workout.

Oh yeah, use alcohol in moderation and have sex frequently. It may be tough to do both since they often go together but do your best.

Remember, this is just advice (like the TMW says), "Do whatever you want to do?"

Bonus information:

Take ZMA - the trio of zinc, magnesium aspartate and vitamin B6 increased testosterone by more than 30% and IGF-1 by 4%.

Blunt cortisol - Higher cortisol means lower testosterone.


Take 5-10 grams of BCAAs in the morning or 800 mg Phosphatidylserine (PS).


Additional information:

How is testosterone made?

From Muscle and Fitness
Stoppani, Jim. "The testosterone diet: finally, a meal plan with one utterly important muscle-building goal: to ramp up your body's levels of testosterone.(NUTRITION). ." Joe Weider's Muscle & Fitness. 67.7 (July 2006): 150(6).

"To understand how diet affects testosterone levels, you first must understand testosterone production and its actions. It all begins in the brain. A hormone called gonadotropin-releasing hormone (GnRH) is released from the hypothalamus (a small section deep within the brain) and travels to the pituitary gland. From here, GnRH stimulates the release of luteinizing hormone, which travels via the blood all the way to the testes, where it activates enzymes that convert cholesterol into testosterone. What you eat can positively or negatively affect any one of these steps.

Your nutritional regimen can also influence testosterone after it's produced. Testosterone travels in the blood to muscle cells and other tissues either as free (or active) testosterone or bound to a carrier protein. Only the free kind can work to increase muscle size by entering the muscle cells. At some tissues, such as fat cells and the brain, fat can be converted into estrogens--yes, the female hormone you don't want in excess in your body, since it can lead to fat gain and inhibit further testosterone production by decreasing brain hormones. Diet can influence the amounts of both active testosterone and estrogens in the blood."
End of Muscle and Fitness excerpt.

Get your bodybuilding stack at Piping Rock Supplements!

Aggressive Strength Testosterone Booster

Sources:
Kadey, Matthew."$#'t you can add to shakes: boost testosterone, burn fat or gain energy with a few hassle-free, supercharged additions to your regular protein drink. " Joe Weider's Muscle & Fitness. 71.13 (Dec 2010): 172(5).

Aceto, Chris."Bodybuilding food alternatives: twelve surprising muscle-building foods. " Flex.   23.5 (July 2005): 90(4).

Vittek, J., and B. L. Slomiany. "Testosterone in royal jelly. " Experientia. 40.1 (Jan 1984): 104(3).

Stoppani, Jim. "Aspire to boost test: use the amino acid D-asp to raise testosterone levels. " Flex. 28.8 (Oct 2010): 113(2).

Stoppani, Jim, and Steve Stiefel. "Test drive: dramatically boost your testosterone levels and muscle gains with this six-week training, nutrition and supplement program. " Flex. 23.11 (Jan 2006): 96(9).


 Scheett, Tim. HIGHER TEST SCORES. Joe Weider's Muscle & Fitness (0744-5105) 20071201. Vol.68,Iss.12;p.243-243

Stoppani, Jim. Raise test scores: an herb for higher testosterone levels.  Flex (8750-8915) 1 Sep 2010. Vol.28,Iss.7;p.109(2)

Jackson, Dwayne. "Size matters (in the gym): make sizable gains with these 10 alternatives to prohormones." Joe Weider's Muscle & Fitness Aug. 2005: 142+. Academic OneFile. Web. 3 Sep. 2012.

The encyclopedia of supplements. Flex (8750-8915) 1 Feb 2012. p.270(7)

Stoppani, Jim; Brown, Jordana. TESTOSTERONE'S LITTLE HELPERS. Joe Weider's Muscle & Fitness (0744-5105) 20080601. Vol.69,Iss.6;p.218-225

Stoppani, Jim. MuscleTech performance series Anotest: an up-close look at MuscleTech's 4-in 1 testosterone booster. Joe Weider's Muscle & Fitness (0744-5105) 1 Jun 2012. Vol.73,Iss.6;p.88(1)

Breakfast boron capsule boosts testosterone from ergo-log.com

Naghii et al., 2011. Comparative effects of daily and weekly boron supplementation. J Trace Elem Med Bio. 25(1):54-58.


To Thy Own Self Be True - Build Muscle Your Way


One things for sure about muscle building is that no two people seem to be the same.

Some guys look at weights and put on muscle while others toil away for years and put on small amounts of muscle yearly. Still others put on as much fat as muscle.

You must find your way. There are starting points you can go by. The infamous bodytypes; endomorph, ectomorph and mesomorph. But beyond those it's an experiment.

One things for sure the focus has to be diet and training first (not necessarily in that order). The season your program with supplementation.

Do you eat:
                   Six times per day.
                   Whey all day and one meal at night.
                   Intermittent Fast - 8 hour eating window, 6 hour, 4 hour.
                   Standard three meals per day.
                   Low Carb, Slow Carb, High Carb, Vegan
                   Squats and Milk

 Do you train:
                   Ironman 4x Positions of Flexion
                   Twinmuscle Workout 3-day Split
                   4-day Split
                   Stronglifts 5x5
                   Super Squats
                   Crossfit
                   Escalating Density Training
                   10x10
                   10x3
                   Standard bodybuilding 3x10 or 3x12
                   Arthur Jones Full Body

You have to figure it out.

Help is always around.

www.bodybuilding.com

Twinmuscleworkout (TMW)Youtube Channel

TMW fastingtwins Youtube Channel

http://www.muscleandfitness.com/

http://www.muscleandbodymag.com/

http://www.ironmanmagazine.com/

http://www.muscleandperformancemag.com/

http://www.t-nation.com/

http://www.leangains.com/

Always search for Dr. Jim Stoppani along with a term to get top quality information.

I'm sure you have your favorites.

Let me know what they are.

wheyblog@gmail.com

Sunday, September 2, 2012

Cutting Stack: BPI Sports A-HD and Solid


I did this stack sometime before I started this blog and was surprised with the results. I started taking it and found that I was leaning out. I hadn't changed my diet and had friends keep telling me that my face was getting leaner. The weird thing was that my weight was not changing but my face and body was looking leaner.

Cool huh.

My favorite BPI Sports products are still Blox and Super Pro but as far as visual results this combo beats them both.

A-HD by itself did nothing for me but I've met guys that love it stand alone. I will probably try A50 in acouple of months.

BPI Sports calls it the Get Hard Stack and it seems to work. I have no idea how because I've searched and searched and can't find anything as far as studies goes.

This is all anecdotal or "Bro Science". Give it a try.

I am always afraid of long-term use of anything that hasn't been used or tested with human subjects. So be cautious.

BPI recommends that you take 1 Solid in the morning and 1 A-HD in the afternoon. I think most days that I took both in the morning.


Here's what's in it.


A-HD™  (formally Arimedex HD™)
(they give a bunch of chemical names but it's really common stuff)

Safflower Seed Extract or Carthamus tinctorius CHEMICAL NAME: (3s,4s)-4-[(3,4-dimethoxyphenyl)methyl]-3-hydroxy-3-[[3-methoxy-4-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-phenyl]methyl]oxolan-2-one

Flax Seed Lignan CHEMICAL NAME: (2r,3r)-2,3-bis[(4-hydroxy-3-methoxyphenyl)methyl]butane-1,4-diol;(2r,3r,4s,5s,6r)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol

Pterostilbene - Similiar to Resveratrol CHEMICAL NAME: 4-[(e)-2-(3,5-dimethoxyphenyl)ethenyl]phenol

Gingerol CHEMICAL NAME: s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone

Caffeate (beehive propolis) CHEMICAL NAME: phenethyl(e)-3-(3,4-dihydroxyphenyl)prop-2-enoate

For a really good treatment of this goto What’s In BPI Arimedex? or BPI Sports A-HD (Arimedex) Ingredients: Snake Oil or TheReal Deal? .

Why not just call it these? Instead of giving names that make you think it's a prohormone combination. Whatever, it did give me results when combined with SOLID.

The below study references was found on www.bodybuilding.com product page.

1] Biosci Biotechnol Biochem. 2006 Nov;70(11):2783-5.
  • [2] J Toxicol Environ Health A. 1999 Apr 23;56(8):555-70.

  • [3] J Vet Med Sci. 2002 Sep;64(9):761-5.

  • [4] J Nutr. 2006 Jun;136(6):1545-51.

  • [5] Exp Biol Med. 2007 Sep;232(8):1071-80.

  • [6] Curr Clin Pharmacol. 2006 Jan;1(1):81-101.

  • [7] Mol Nutr Food Res. 2010 Mar;54(3):335-44.

  • [8] Ir J Reprod Med. 2009 Winter;7(1):7-12.

  • [9] Ann NY Acad Sci. 2004 Dec;1030:501-7.

  • [10] J Steroid Biochem Mol Biol. 2009 Jan;113(1-2):65-74.


  • SOLID™
    Proprietary Blend 100mg
    Borassus Aethiopum (Germinating Shoot) *
    Tulbaghia Violacea Harv. (Leaf And Rhizome) *
    Cynodon Dactylon (Aerial) *

    Found the below on a forum at www.supplementreviews.com .

    SOLID™'s dual Anabolic and Androgenic activity results from the fact that it's formulated with a novel class of naturally-occurring compounds...* Compounds which appear to effectively bind to androgen receptors, and modulate protein synthesis and help decrease protein breakdown.* 1 The anabolic actions of androgens are demonstrated through changes in body, plasma amino acid level, and plasma urea level, among other indicators. 4-7

    The physiological (regulation, metabolism, and mechanisms) importance of this dual anabolic and androgenic activity simply cannot be understated.* It is T-H-E key. The key to SOLID™, the key to getting the hardening, definition, strength, and vascular effects you want... and, need, to be contest ready! †*


    † When combined with a proper exercise and nutrition regimen.

    The below study references were found on www.bodybuilding.com product page.

    REFERENCES:
    [1] J Sci Res. 2010; 2(2): 362-8.
    [2] J Young Pharm. 2011 Jan-Mar; (3)1: 26-35.
    [3] J Ethnopharmacol. 2010; 132: 359-61.
    [4] J Appl Physiol. 1989 Jan;66(1):498-503.
    [5] J Appl Physiol. 1991 Mar;70(3):1038-43.
    [6] Metabolism. 1985 Jun;34(6):571-3.
    [7] Endocr Rev. 1987 Feb;8(1):1-28.

    http://www.mikemahler.com/cmd.php?Clk=5223690


    Starting Green Coffee Bean Extract Tomorrow



    There are lots of green coffee bean products out there. Life Extension, Top Secret, Futurebiotics, Resverage, Biogenetic Laboratories to name a few. I recently met a guy who lost 20 pounds over the past month taking one capsule (400mg) before each meal. He also said he has more energy without the drained feeling in the afternoon.

    I like the theory behind green coffee bean extract because it is based on sugar control. Slowing the insulin response to high blood sugar levels seem to be key. From what I've read, excess sugars are either shuttled into muscle or fat by insulin and if you haven't used up all the sugars in muscle by working out, it has no where to go but into fat. If you aren't always low or slow carb you will have considerable fat accumulation.

    I bought some today and will start it tomorrow. It appears that everyone else in town is buying it too because I there was only one bottle left of each of the brands above when I went to get it. I bought the Life Extension Coffeegenic brand. Why because they always back up their products with study references. I will update you when the bottle is empty.

    Dr. Oz recommends 800mg twice per day. I'm going to do 400mg with each of my meals because I'm not made of money.
    Like my USPLabs Fear No Workout Shirt?
    I have a hole in my afro.

    The below study references are from Life Extension Magazine February 2012 edition.

    Green Coffee Bean Extract

    The effect of chlorogenic acid enriched coffee on glucose absorption in healthy volunteers and its effect on body mass when used long-term in overweight and obese people.
    The results from a clinical study performed in 12 healthy volunteers with different coffee products containing glucose show that instant coffee enriched with chlorogenic acid induced a reduction in the absorption of glucose of 6.9% compared with the control. No such effects were seen with normal or decaffeinated instant coffee. In a second, comparative, randomized, double-blind, 12-week study we investigated the effect on the body mass of 30 overweight people, compared with normal instant coffee. The average losses in mass in the chlorogenic acid enriched and normal instant coffee groups were 5.4 and 1.7 kg, respectively. We conclude that chlorogenic acid enriched instant coffee appears to have a significant effect on the absorption and utilization of glucose from the diet. This effect, if the coffee is used for an extended time, may result in reduced body mass and body fat when compared with the use of normal instant coffee.
    J Int Med Res. 2007 Nov-Dec;35(6):900-8
    Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.
    OBJECTIVE: Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance. RESEARCH DESIGN AND METHODS: We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee, 1 g chlorogenic acid, 500 mg trigonelline, and placebo (1 g mannitol) on glucose and insulin concentrations during a 2-h oral glucose tolerance test (OGTT) in 15 overweight men. RESULTS: Chlorogenic acid and trigonelline ingestion significantly reduced glucose (-0.7 mmol/l, P = 0.007, and -0.5 mmol/l, P = 0.024, respectively) and insulin (-73 pmol/l, P = 0.038, and -117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. None of the treatments affected insulin or glucose area under the curve values during the OGTT compared with placebo. CONCLUSIONS: Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT.
    Diabetes Care. 2009 Jun;32(6):1023-5
    Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice.
    BACKGROUND: An epidemiological study conducted in Italy indicated that coffee has the greatest antioxidant capacity among the commonly consumed beverages. Green coffee bean is rich in chlorogenic acid and its related compounds. The effect of green coffee bean extract (GCBE) on fat accumulation and body weight in mice was assessed with the objective of investigating the effect of GCBE on mild obesity. METHODS: Male ddy mice were fed a standard diet containing GCBE and its principal constituents, namely, caffeine and chlorogenic acid, for 14 days. Further, hepatic triglyceride (TG) level was also investigated after consecutive administration (13 days) of GCBE and its constituents. To examine the effect of GCBE and its constituents on fat absorption, serum TG changes were evaluated in olive oil-loaded mice. In addition, to investigate the effect on hepatic TG metabolism, carnitine palmitoyltransferase (CPT) activity in mice was evaluated after consecutive ingestion (6 days) of GCBE and its constituents (caffeine, chlorogenic acid, neochlorogenic acid and feruloylquinic acid mixture). RESULTS: It was found that 0.5% and 1% GCBE reduced visceral fat content and body weight. Caffeine and chlorogenic acid showed a tendency to reduce visceral fat and body weight. Oral administration of GCBE (100 and 200 mg/kg. day) for 13 days showed a tendency to reduce hepatic TG in mice. In the same model, chlorogenic acid (60 mg/kg. day) reduced hepatic TG level. In mice loaded with olive oil (5 mL/kg), GCBE (200 and 400 mg/kg) and caffeine (20 and 40 mg/kg) reduced serum TG level. GCBE (1%), neochlorogenic acid (0.028% and 0.055%) and feruloylquinic acid mixture (0.081%) significantly enhanced hepatic CPT activity in mice. However, neither caffeine nor chlorogenic acid alone was found to enhance CPT activity. CONCLUSION: These results suggest that GCBE is possibly effective against weight gain and fat accumulation by inhibition of fat absorption and activation of fat metabolism in the liver. Caffeine was found to be a suppressor of fat absorption, while chlorogenic acid was found to be partially involved in the suppressive effect of GCBE that resulted in the reduction of hepatic TG level. Phenolic compounds such as neochlorogenic acid and feruloylquinic acid mixture, except chlorogenic acid, can enhance hepatic CPT activity.
    BMC Complement Altern Med. 2006 Mar 17;6:9
    Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice.
    The prevalence of obesity is increasing globally, and obesity is a major risk factor for type 2 diabetes and cardiovascular disease. We investigated the effects of coffee polyphenols (CPP), which are abundant in coffee and consumed worldwide, on diet-induced body fat accumulation. C57BL/6J mice were fed either a control diet, a high-fat diet, or a high-fat diet supplemented with 0.5 to 1.0% CPP for 2-15 wk. Supplementation with CPP significantly reduced body weight gain, abdominal and liver fat accumulation, and infiltration of macrophages into adipose tissues. Energy expenditure evaluated by indirect calorimetry was significantly increased in CPP-fed mice. The mRNA levels of sterol regulatory element-binding protein (SREBP)-1c, acetyl-CoA carboxylase-1 and -2, stearoyl-CoA desaturase-1, and pyruvate dehydrogenase kinase-4 in the liver were significantly lower in CPP-fed mice than in high-fat control mice. Similarly, CPP suppressed the expression of these molecules in Hepa 1-6 cells, concomitant with an increase in microRNA-122. Structure-activity relationship studies of nine quinic acid derivatives isolated from CPP in Hepa 1-6 cells suggested that mono- or di-caffeoyl quinic acids (CQA) are active substances in the beneficial effects of CPP. Furthermore, CPP and 5-CQA decreased the nuclear active form of SREBP-1, acetyl-CoA carboxylase activity, and cellular malonyl-CoA levels. These findings indicate that CPP enhances energy metabolism and reduces lipogenesis by downregulating SREBP-1c and related molecules, which leads to the suppression of body fat accumulation.
    Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E122-33
    National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2•7 million participants.
    BACKGROUND: Data for trends in glycaemia and diabetes prevalence are needed to understand the effects of diet and lifestyle within populations, assess the performance of interventions, and plan health services. No consistent and comparable global analysis of trends has been done. We estimated trends and their uncertainties in mean fasting plasma glucose (FPG) and diabetes prevalence for adults aged 25 years and older in 199 countries and territories. METHODS: We obtained data from health examination surveys and epidemiological studies (370 country-years and 2•7 million participants). We converted systematically between different glycaemic metrics. For each sex, we used a Bayesian hierarchical model to estimate mean FPG and its uncertainty by age, country, and year, accounting for whether a study was nationally, subnationally, or community representative. FINDINGS: In 2008, global age-standardised mean FPG was 5•50 mmol/L (95% uncertainty interval 5•37-5•63) for men and 5•42 mmol/L (5•29-5•54) for women, having risen by 0•07 mmol/L and 0•09 mmol/L per decade, respectively. Age-standardised adult diabetes prevalence was 9•8% (8•6-11•2) in men and 9•2% (8•0-10•5) in women in 2008, up from 8•3% (6•5-10•4) and 7•5% (5•8-9•6) in 1980. The number of people with diabetes increased from 153 (127-182) million in 1980, to 347 (314-382) million in 2008. We recorded almost no change in mean FPG in east and southeast Asia and central and eastern Europe. Oceania had the largest rise, and the highest mean FPG (6•09 mmol/L, 5•73-6•49 for men; 6•08 mmol/L, 5•72-6•46 for women) and diabetes prevalence (15•5%, 11•6-20•1 for men; and 15•9%, 12•1-20•5 for women) in 2008. Mean FPG and diabetes prevalence in 2008 were also high in south Asia, Latin America and the Caribbean, and central Asia, north Africa, and the Middle East. Mean FPG in 2008 was lowest in sub-Saharan Africa, east and southeast Asia, and high-income Asia-Pacific. In high-income subregions, western Europe had the smallest rise, 0•07 mmol/L per decade for men and 0•03 mmol/L per decade for women; North America had the largest rise, 0•18 mmol/L per decade for men and 0•14 mmol/L per decade for women. INTERPRETATION: Glycaemia and diabetes are rising globally, driven both by population growth and ageing and by increasing age-specific prevalences. Effective preventive interventions are needed, and health systems should prepare to detect and manage diabetes and its sequelae.
    Lancet. 2011 Jul 2;378(9785):31-40
    A large proportion of prediabetes and diabetes goes undiagnosed when only fasting plasma glucose and/or HbA1c are measured in overweight or obese patients.
    AIMS: The purposes of the study were to determine the prevalence of unrecognized dysglycaemia in overweight (body mass index [BMI] 25-29.9 kg/m(2)) and obese (BMI ≥30 kg/m(2)) patients, to assess the extent to which measures of fasting plasma glucose (FPG) and/or HbA(1c), compared with oral glucose tolerance tests (OGTTs), misdiagnose dysglycaemia, and to determine the factors associated with an isolated abnormal post-OGTT glucose value. METHODS: OGTT was performed and HbA(1c) was measured in 1283 inpatients with BMI scores ≥ 25 kg/m(2) and no history of dysglycaemia. RESULTS: Prediabetes was found in 257 (20.0%) subjects (197 with impaired glucose tolerance, 29 with impaired fasting glucose, 31 with both) and diabetes in 77 (6.0%), including 22 with FPG ≥ 7 mmol/L (WHO definition). The sensitivity of FPG >6 mmol/L, FPG >5.5 mmol/L, HbA(1c) ≥ 6% and the recommendations of the French National Agency of Accreditation and Evaluation in Health Care (ANAES) to identify patients with abnormal OGTTs was 29.9, 41.3, 36.8 and 15.6%, respectively. The factors that were independently associated with diabetes in obese women with FPG <7 mmol/L were age (per 10 years: OR 1.54 [1.00-2.11]; P=0.049) and FPG (OR 6.1 [1.4-30.0]; P=0.014), whereas age (OR 1.26 [1.09-1.44]; P<0.01) and waist circumference (per 10 cm: OR 1.17 [1.01-1.33]; P<0.05) were independently associated with dysglycaemia in obese women with FPG <6.1 mmol/L. CONCLUSION: In overweight and obese patients: dysglycaemia is commonly seen; FPG alone, compared with OGTT, failed to diagnose 70% of dysglycaemia cases; FPG >5.5 mmol/L and HbA(1c) ≥ 6.0% are not necessarily substitutes for OGTT; and older age and larger waist circumference should be used to select those obese women with normal FPG who might further benefit from OGTTs to diagnose dysglycaemia.
    Diabetes Metab. 2010 Sep;36(4):312-8
    Chlorogenic acid reduces the plasma glucose peak in the oral glucose tolerance test: effects on hepatic glucose release and glycaemia.
    The effects of chlorogenic acid (CA) on hepatic glucose output, blood glucose levels and on glucose tolerance were analysed. Hepatic uptake of CA and its effects on hepatic catabolism of L-alanine and glucose-6-phosphatase (G-6-Pase) activity were also evaluated. CA (1 mM) inhibited about 40% of G-6-Pase activity (p < 0.05) in the microsomal fraction of hepatocytes, but no effect was observed on production of glucose from gluconeogenesis or on L-alanine catabolism, at various concentrations of CA (0.33, 0.5 and 1 mM), in liver perfusion experiments. Since there were indications of a lack of uptake of CA by the liver, it is possible that this compound did not reach sufficiently high intracellular levels to inhibit the target enzyme. Accordingly, intravenous administration of CA also failed to provoke a reduction in blood glucose levels. However, CA did promote a significant reduction (p < 0.05) in the plasma glucose peak at 10 and 15 min during the oral glucose tolerance test, probably by attenuating intestinal glucose absorption, suggesting a possible role for it as a glycaemic index lowering agent and highlighting it as a compound of interest for reducing the risk of developing type 2 diabetes.
    Cell Biochem Funct. 2008 Apr;26(3):320-8
    Characterization of inhibitors of postprandial hyperglycemia from the leaves of Nerium indicum.
    Nerium indicum is an India-Pakistan-originated shrub belonging to the oleander family. The ingestion of leaves of N. indicum before a meal is known to effect the lowering of postprandial glucose levels in type II diabetic patients and this plant is now used as a folk remedy for type II diabetes in some regions of Pakistan. In the present study, the hot-water extract of N. indicum leaves was found to reduce the postprandial rise in the blood glucose when maltose or sucrose was loaded in rats. It was also found that the extract strongly inhibited alpha-glucosidase, suggesting that the suppression of the postprandial rise in the blood glucose is due to the occurrence of some inhibitors of alpha-glucosidase in the leaves. We, therefore, tried to isolate the active principles from the leaf extract, using alpha-glucosidase-inhibitory activity as the index. Employing Sephadex G-15, silica gel and reversed-phase HPLC, we isolated two active compounds. The UV, mass and NMR spectrometric analyses established that the chemical structures of these compounds are 3-O-caffeoylquinic acid (chlorogenic acid) and its structural isomer, 5-O-caffeoylquinic acid. Both compounds were shown to inhibit alpha-glucosidases in a non-competitive manner. The authentic chlorogenic acid was found to suppress the postprandial rise in the blood glucose in rats and also inhibited the absorption of the glucose moiety from maltose and glucose in the everted gut sac system prepared from rat intestine. These results demonstrate that chlorogenic acid is one of the major anti-hyperglycemic principles present in the leaves of N. indicum. Furthermore, among polyphenol compounds tested, quercetin and catechins were shown to have strong inhibitory activity against alpha-glucosidase.
    J Nutr Sci Vitaminol (Tokyo).2007 Apr;53(2):166-73

    Leucine is King (Part 4): Headlines from ergo-log.com


    Don't take my word for the value of leucine. Go to my favorite site to check out some of this stuff www.ergo-log.com.

    Here's some of the headlines found on ergo.






















     





    Friday, August 31, 2012

    My Weight Loss Story. The whey I did it.

    I was in bad shape. I had no energy, no drive and I was constantly coughing. I was sleepy, my mind seemed foggy, my back ached and my arms and legs would swell to the point where I couldn't bend my fingers or knees.




    When I got laid off, I thought who would hire me. I look like I would die on the job.






    I decided to do whey shakes and low carb and it worked. I first combined the approach with walking then went to Kmart and put a weight bench in layaway. I really started making some gains in muscle, fatloss and confidence.

    RxBar Real Food Protein Bars Variety Pack, 5 Flavor, 1.83 Ounce Bars (Pack of 10)
    Thanks to craigslist I stepped up to olympic weights and a squat rack. I haven't looked back.

    I had lots of protein shakes but primarily used:

    Vitaminshoppe BodyTech
    Body Fortress Whey
    Syntrax
    Iron-Tek Essential
    Dymatize Elite Iso
    Dymatize Elite XT
    Optimum Nutrition Gold Standard
    Isopure Zero Carb

    My typical day:
    6 a.m. - shake (pre-workout)
    8 a.m. - shake (post-workout)
    10 a.m. - shake
    12 p.m. - shake
    solid food the rest of the day



    Here's some of numbers from my journey.


    6/22/2009 – weight 247lbs

                                        Short of breath, sleep, low sex drive, hip pain, muscle spasms, feet, ankles and sometimes legs swelling, hands swelling, coughing, right shoulder and arm pain.

                                        Cannot do push-ups.  Painful shoulder.

                                        Cannot do pull-ups.

                                        Started walking on treadmill.

    10/1/2009 -            Started weight training.

                                        Cannot do push-ups.

    11/30/2009 –         MAX:                        bench press            175lbs

                                                                Curl                91.5lbs

    12/7/2009 -            MAX:             bench press 195lbs x 2

    1/1/2010 - weight 229lbs

    1/17/2010 – measurement – abdomen 48

    1/17/2010 – past carbohydrate history (weight loss per week)

                                        22 grams per day lost 6lbs

                                        95/day lost 5lbs

                                        110/day lost 1lb

                                        115/day lost 3.5lbs (with exercise)

                                        150/day lost 1lb

    2/22/2010 - measurements

                            Chest              46

                            Abdomen     46

                            Left Bicep      14.5

                            Right Bicep   15.5

                            Right Thigh   22

                            Left Thigh     21

    2/23/2010 – started working out left bicep and tricep on a second day to even out the size with the right arm.

    3/8/2010 – started Muscle and Fitness 4-week Strength Band Workout

                            Surprisingly, I was extremely sore after these workouts.

    3/22/2010 – measurements

                            Chest              41

                            Abdomen     46

                            Left Bicep      17

                            Right Bicep   17

                            Neck               17

    4/1/2010 – started TABATA HIIT workouts (4 minutes)

    4/2/2010 – Able to do push-ups again!

    5/17/2010 -  First time using chains with ez-bar curls

    5/18/2010 -            MAX:             chins  2

                                        Note:  negative-accentuated technique [one second up/six seconds down]

                                        Note:  "After [a series of full-range reps] you'll find it impossible to do a complete repetition. But that does not mean the biceps muscle is completely exhausted. You'll find with some effort that you are still able to get a few half repetitions...and when you can no longer do the half movements, you'll find you can do a couple of quarter repetitions."

                                       

    5/26/2010 -            MAX:             bench press 225lbs

    6/1/2010 – Adopted new workout philosophy.   From books Muscle Logic and Get Huge in a Hurry.  Morning cardio on empty stomach.

                                        Example:  15 minutes circuit

                                                                Pull-ups/Bench Press/Squat-Press

                                                                Treadmill wearing weighted vest.
                                      

    7/12/2010 – weight 213 lbs.

    7/16/2010 – Did 20 push-ups and 5 pull-ups straight.

    8/5/2010 – Did 7 pull-ups straight.

    8/8/2010 – Did 25 push-ups straight.

    8/15/2010 – measurements

                            Chest              46

                            Abdomen     41

                            Left Bicep      16

                            Right Bicep   16

                            Right Thigh   24

                            Left Thigh     24

    9/20/2010 – weight 205 lbs.

                                        I am able to button my USAF BDU pants again.

    11/13/2010 – measurements

                            Chest              40

                            Abdomen     42

                            Left Bicep      17.5

                            Right Bicep   17

    11/13/2010 – weight 195 lbs.


    12/19/2010 -          MAX:             Curl 123 lbs x 1

    12/25/2010 – Did 30 push-ups straight.

    6/14/2011 – able to fit size 34 waist pants, down from 46 inch pants size.
    Some of the numbers and dates don't seem to jive for me but I put them in here as logged them in my journal.
    I stopped typing in my journal here. I need to update it so I can update you.