Wednesday, March 27, 2013

The Cortisol Control, Estrogen Blocker, Aromatase Inhibitor (AI) and cortisol inhibitor - Androsta-3,5-diene-7,17-dione (Arimistane)

Arimistane™ promoted as a potent aromatase inhibitor (AI) that works to decrease circulating levels of estrogen in the body along with cortisol levels.

It is purported to reduce the amount of androgens in the body that can convert into estrogen by acting as a suicide inhibitor. Binding to the aromatase enzyme and creating an irreversible reaction.

Word of caution.
This from Patrick Arnold over at Prohormone
"The whole family of 7-oxygenated dhea metabolites are fascinating compounds, for many reasons other than aromatase inhibition. The compound under discussion here is not a major metabolite though, and so its very unlikely you could acheive therapeutic drug levels in your body by ingesting any reasonable amount of 7-keto"

Products containing Arimistane:
PES' Erase
PES' NEW Erase Pro
LeCheek Nutrition's AD-3 PCT
Redefine Nutrition (Finaflex) PCT Revolution Black
Man Nolvadren-XT
Ironmaglabs E-Control 2.0


Schubert K, Wehrberger K, Hobe G; Androsta-3,5-diene-7,17-dione: isolation from urine and formation from 7-keto-dehydro-epiandrosterone sulphate under various conditions of hydrolysis; Endocrinol Exp. 1971 Dec;5(4):205-10

Numazawa M, Mutsumi A, Tachibana M, Hoshi K; Synthesis of androst-5-en-7-ones and androsta-3,5-dien-7-ones and their related 7-deoxy analogs as conformational and catalytic probes for the active site of aromatase; J Med Chem. 1994 Jul 8;37(14):2198-2

Ashok Marwah, Padma Marwah, Henry Lardy; Ergosteroids VI. Metabolism of dehydroepiandrosterone by rat liver in vitro: a liquid chromatographic–mass spectrometric study. Journal of Chromatography B, 767 (2002) 285–299