- 1772 -- NO is discovered by Joseph Priestly. It's believed to be a toxic gas for more than 200 years.
- 1986 -- NO is found to be produced naturally in the body of humans and other mammals and acts to relax blood vessels.
- 1997 -- MRI Launches NO2 - arginine-akg
- 1998 -- The discovery of NO and its role in blood vessel dilation wins the Nobel Prize.
- 1999 -- MHP launches TRAC, combining arginine and creatine for the first time.
- 2004 -- BSN introduces NO-XPLODE the first pre-workout with stimulants, creatine and electrolytes.
- 2006 -- MuscleTech releases naNOx9, a NO booster encased in a rapid-delivery caplet for almost immediate results.
- 2008 -- BSN reformulates N.O.-Xplode to include beta-alanine and several different forms of creatine,
- 2009 -- MuscleMeds introduces eNoxide, with NO bound to an amino acid that delivers NO when the molecule divides.
- 2010 -- MHP uses GPLC to take advantage of the nitrate-nitrite pathway in NO-Bomb
- 2011 -- UGENX Releases Unleashed Pump'D Nitric Gel, a topical gel that allows for site-specific increases in NO-mediated blood flow.
Stoppani, Jim. "Turbo boost: to understand the complexities and
effectiveness of the supplement products in today's pre-workout category, you
need to understand where it all started: NO boosters." Joe Weider's Muscle
& Fitness Sept. 2011: 154+.
