Tuesday, November 6, 2012

William Llewellyn PH Labs Augment: Anabolic Hormone Amplification Technology

This is an exciting sounding new product that was designed by the Anabolics author William Llewellyn. All of the ingredients have been used in products before, but I don't think they have all been combined into one product.
The below information is from the PH Labs website.
AUGMENT is a third generation anabolic agent/hormone amplifier developed exclusively for pH Labs by renowned anabolic scientist William Llewellyn. AUGMENT works by increasing testosterone and IGF-1 sensitivity in muscle cells after training. These two hormones are the primary regulators of muscle protein synthesis. Increasing their activity within the muscles means more protein can be synthesized, and thus more muscle and strength gained.

ARASYN - 40% Arachidonic Acid (USP #6,841,573)

Arachidonic acid, an omega-6 essential fatty acid, is critical for muscle growth. Release and metabolism of this EFA is directly responsible for remodeling muscle physiology during the recovery window, where it is a core regulator of protein synthesis. ARA has also been shown to increase lateral cell diameter, contractile protein content, and nuclei number in developing muscle fibers (myotubes). An enhancement of IGF-1 activity is likely responsible for much of this activity. However, ARA has also been shown to elevate androgen receptor concentrations in some tissues, suggesting it may support both testosterone and IGF-1 related anabolic actions. Note that studies show ARA is depleted from muscle tissue with regular exercise. Therefore, supplementation can be key to maintaining an optimal ongoing environment for growth within our muscles. Independent placebo-controlled University studies have also demonstrated that ARA has ergogenic activity in resistance-trained adults.

LoMax Loquat Leaf Extract (25% Ursolic Acid)

Usrolic acid (3-ß-hydroxy-urs-12-en-28-oic acid) is a pentacyclic triterpene found widely in various foods, herbs, and plant species. UA is a highly active natural compound, with antioxidant, hepatoprotective, blood sugar lowering, cholesterol lowering, antibiotic, and antiviral activity . It also appears to be notably anabolic. While ursolic acid has a long history of use in traditional natural medicine, it is very new in bodybuilding and athletic circles. Its positive effects here, however, have been quickly made apparent. Much is likely mediated by IGF-1, with studies finding ursolic acid to substantially increase the signaling capacity of this hormone within skeletal muscle. On top of this, UA has been shown to inhibit key cellular catabolic processes, which could otherwise slow the rate of new muscle gain. At least one study suggests it may also augment androgen receptor concentrations, enhancing testosterone uptake. With this broad spectrum of localized action, ursolic acid is an ideal candidate for further shifting the anabolic/catabolic balance during recovery.

LCLT-Refined (Ultra-Purified L-Carnitine L-Tartrate)

LCLT is a modified form of the amino acid L-carnitine, in this case one designed for enhanced delivery and utilization. This ingredient is also fairly new, though already has compelling data behind it, especially for the purposes needed with this supplement. In particular, studies have shown that LCLT is a potent upregulator of muscle androgen receptor density. During placebo-controlled studies with recreationally trained adult men, 2 grams of L-carnitine (as LCLT) per day resulted in more than a 15% increase in the number of androgen receptors within muscle cells. This should equate to a substantial increase in the uptake and physiological capacity of testosterone in these tissues. Additional placebo-controlled studies found that LCLT substantially reduces markers of muscle breakdown following resistance training in both men and women. These activities allow L-carnitine L-tartrate to work strongly and synergistically with arachidonic acid and ursolic acid, the three substantially shifting post-exercise muscle physiology in favor of anabolism.

Other posts:
Arachidonic Acid - Kick Start New Muscle Growth